mastl
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  • Official Full Name
  • microtubule associated serine/threonine kinase-like
  • Background
  • This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.
  • Synonyms
  • MASTL; microtubule associated serine/threonine kinase-like; serine/threonine-protein kinase greatwall; FLJ14813; THC2; 2700091H24Rik; C88295; GW; GWL; GWL_HUMAN; hGWL; MAST-L; MGC117975; microtubule associated serine/threonine kinase like; Microtubule-associated serine/threonine-protein kinase-like; RP11 85G18.2; greatwall protein kinase; GREATWALL; RP11-85G18.2
Cat.#:MASTL-156HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MASTL Protein, GST-tagged, Active
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Cat.#:MASTL-757HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MASTL, His-tagged
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Cat.#:MASTL-9582MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MASTL Protein
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Cat.#:MASTL-1035ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MASTL
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Cat.#:MASTL-4456HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MASTL 293 Cell Lysate
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Involved Pathway

MASTL involved in several pathways and played different roles in them. We selected most pathways MASTL participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, M Phase, which may be useful for your reference. Also, other proteins which involved in the same pathway with MASTL were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
CDC6; CEP76; CDKN1BB; RAD17; CENPW; GADD45BB; ODF2; TGFB1A; CDC25A; LIN52
Cell Cycle, Mitotic
CDK4; DNA2; TOP2A; CENPK; KIF2C; ZW10; CTDNEP1B; STAG1; NUMA1; CEP135
M Phase
MAU2; ANKLE2; ENSA; CENPN; ERCC6L; CNEP1R1; ZW10; SGOL2; ENSAB; MASTL
MASTL Facilitates Mitotic Progression
ARPP19B; ENSAA; MASTL; ENSAB; ARPP19; ARPP19A; ENSA
Mitotic Prophase
GORASP2; TMEM188; PHF8; ARPP19A; SMC2; NCAPG2; NCAPH2; NEK9; CNEP1R1; NEK7

Protein Function

MASTL has several biochemical functions, for example, ATP binding, kinase activity, protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MASTL itself. We selected most functions MASTL had, and list some proteins which have the same functions with MASTL. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CSNK1A1L; TLK1A; MAP3K9; NME3; PIP5K2; ULK1; CAMKV; MYH1B; PGK2; EPHB2B
Function kinase activity
Related Protein CSF1RA; TAOK1; CAMK2N1A; ALPK2; MOB1BA; STK24B; STK35L; BCKDK; EPHA4A; RAF1A
Function protein phosphatase 2A binding
Related Protein CPD; SHC1; AKT1; MASTL; ARPP19; HMGCR; PPP2R4; BCL2; PTPN1; PPME1
Function protein serine/threonine kinase activity
Related Protein MAP2K2A; MAP3K12; TRPM6; TBK1; STK17B; STK35; PAK6; NIM1; CDK14; ACVR2A

Interacting Protein

MASTL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MASTL here. Most of them are supplied by our site. Hope this information will be useful for your research of MASTL.
Dynll1; MED26; SSFA2; TAP2; CDK18; RPS6KA1; SLC1A5; MRPL2; ACBD5; CEP85; FASTKD5; TMEM263; PLEKHA8; DERL2; EPB41L5; UBN1; TELO2

MASTL Related Articles

Wang, L; Fisher, LA; et al. Monoclonal Antibodies Against Xenopus Greatwall Kinase. HYBRIDOMA 30:469-474(2011).