MCOLN1 Protein, mucolipin 1


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Official Full Name mucolipin 1
Background This gene encodes a memberof the transient receptor potential (TRP) cation channel gene family. The transmembrane protein localizes to intracellular vesicular membranes including lysosomes, and functions in the late endocytic pathway and in the regulation of lysosomal exocytosis. The channel is permeable to Ca(2+), Fe(2+), Na(+), K(+), and H(+), and is modulated by changes in Ca(2+) concentration. Mutations in this gene result in mucolipidosis type IV.
Synonyms MCOLN1; mucolipin 1; mucolipin-1; ML4; MLIV; MST080; MSTP080; TRPM L1; TRPML1; MCLN1_HUMAN; Mcoln 1; MG 2; MG-2; MG2; ML 4; Mucolipidin; Mucolipin1; TRP ML1; mucolipidosis type IV protein; TRP-ML1; TRPM-L1
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MCOLN1-4414HCL Recombinant Human MCOLN1 293 Cell Lysate HEK293 N/A
    Human MCOLN1-4513H Recombinant Human MCOLN1 Protein, GST-tagged Wheat Germ GST
    Human MCOLN1-784H Recombinant Human MCOLN1, His-tagged E.coli His
    Mouse MCOLN1-9644M Recombinant Mouse MCOLN1 Protein Mammalian Cell His
    Cynomolgus Monkey MCOLN1-679C Recombinant Cynomolgus MCOLN1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque MCOLN1-2708R Recombinant Rhesus monkey MCOLN1 Protein, His-tagged Mammalian Cell His

    MCOLN1 involved in several pathways and played different roles in them. We selected most pathways MCOLN1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCOLN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lysosome IDUA; GNSA; AP4E1; NAGPA; TPP1; ATP6V0A4; AP1S3; CTSK; ACP5; HYAL1

    MCOLN1 has several biochemical functions, for example, NAADP-sensitive calcium-release channel activity, cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCOLN1 itself. We selected most functions MCOLN1 had, and list some proteins which have the same functions with MCOLN1. You can find most of the proteins on our site.

    Function Related Protein
    NAADP-sensitive calcium-release channel activity MCOLN1; TPCN2; TPCN1
    cation channel activity P2RX1; GRIN3B; PKD2L1; ASIC4B; FAM38A; FAM26D; TRPM1; GRIN2C; ASIC3; MCOLN1

    MCOLN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCOLN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCOLN1.

    TRIM27; SLC35E1

    Zhang, F; Jin, S; et al. TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+release channel in coronary arterial myocytes. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 13:3174-3185(2009).
    Zhang, F; Li, PL; et al. Reconstitution and characterization of a nicotinic acid adenine dinucleotide phosphate (NAADP)-sensitive Ca2+ release channel from liver Lysosomes of rats. JOURNAL OF BIOLOGICAL CHEMISTRY 282:25259-25269(2007).

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