med10
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  • Official Full Name
  • Mediator complex subunit 10
  • Background
  • MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II.
  • Synonyms
  • MED10; mediator complex subunit 10; L6; NUT2; TRG20; mediator of RNA polymerase II transcription subunit 10; TRG-17; TRG-20; transformation-related gene 17 protein; HNUT2; MGC5309; transformation-related gene 20 protein; mediator of RNA polymerase II transcription, subunit 10; mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae); OTTHUMP00000220564
Cat.#:MED10-801HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MED10, GST-tagged
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Cat.#:MED10-9680MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MED10 Protein
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Cat.#:MED10-683CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MED10 Protein, His-tagged
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Cat.#:MED10-2716RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MED10 Protein, His-tagged
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Cat.#:MED10-2457ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED10
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Cat.#:MED10-4393HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MED10 293 Cell Lysate
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Involved Pathway

MED10 involved in several pathways and played different roles in them. We selected most pathways MED10 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED10 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
JAK1; WDR83; SEMA4D; EFNB1; CNKSR1; LGI1A; RGMB; ST8SIA2; MED15; MED25
Fatty acid, triacylglycerol, and ketone body metabolism
ACOT8; APOA5; SLC25A20; ECI1; SREBF2; MED31; MED23; ACOT10; MED25; AGPAT1
Gene Expression
NR2E3; WHSC2; GATAD2AB; COX6A1; TCEB3; WDR4; ZNF317; ZNF549; ZNF791; IGF2BP3
Generic Transcription Pathway
ZNF2; NR4A2B; ZNF12; ZNF70; ZKSCAN1; MED6; ZNF573; SKIB; ZNF222; NR5A1B
Metabolism
KCNJ11; MED26; CERS4A; ARL2; MED15; SAT1B; DGAT1B; CKBA; BRSK2; GLS2B
Metabolism of lipids and lipoproteins
SREBF2; FABP9; NEU3; GLTP; EBP; ARSE; CPTP; ACSF2; ACOT12; MED20
PPARA activates gene expression
MED20; SREBF2; MED6; MED18; ANKRD1; MTF1; MED22; MED25; TIAM2; GRHL1
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
MED9; MED7; GRHL1; G0S2; CDK19; MED10; MED29; MED31; MED21; GLIPR1

Protein Function

MED10 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED10 itself. We selected most functions MED10 had, and list some proteins which have the same functions with MED10. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription cofactor activity
Related Protein MED19A; CRSP7; MED13B; CNOT2; MED1; MED10; MED15; MED20; MED12; MED26
Function protein binding
Related Protein E2F7; ALPI; FSTL3; DNAJC27; YIPF2; TRIM63; COMT; POLR1A; PRDX1; EDA
Function ubiquitin protein ligase activity
Related Protein RNF152; MSL2A; PJA1; RNF19A; RNF7; UBE2V2; MGRN1; MARCH1; MED10; RNF115

Interacting Protein

MED10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED10.
MED19; MED8; MED17

MED10 Related Articles

Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
Wu, YM; Chang, JW; et al. Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM. EMBO JOURNAL 31:3575-3587(2012).