MED18 Protein, mediator complex subunit 18


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Official Full Name mediator complex subunit 18
Background MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate;transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).
Synonyms MED18; mediator complex subunit 18; mediator of RNA polymerase II transcription, subunit 18 homolog (S. cerevisiae); mediator of RNA polymerase II transcription subunit 18; FLJ20045; p28b; Human Mediator of RNA Polymerase II Transcription; hMED 18; hMED18; MED18_HUMAN; Mediator of RNA polymerase II transcription subunit 18 homolog; OTTHUMP00000003645; TRAP/mediator complex subunit p28b; mediator of RNA polymerase II transcription, subunit 18 homolog
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED18-1073HCL Recombinant Human MED18 cell lysate N/A
    Human MED18-4475H Recombinant Human MED18 Protein, GST-tagged Wheat Germ GST
    Human MED18-65H Recombinant Human MED18 protein, His-tagged E.coli His
    Human MED18-805H Recombinant Human MED18, GST-tagged E.coli GST
    Mouse MED18-9690M Recombinant Mouse MED18 Protein Mammalian Cell His
    Zebrafish MED18-10659Z Recombinant Zebrafish MED18 Mammalian Cell His

    MED18 involved in several pathways and played different roles in them. We selected most pathways MED18 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology CRMP1; SEMA3AB; DPYSL3; INSM1B; MED10; EFNA3; EZRA; KIF4; CACNG2B; SCN3A
    Fatty acid, triacylglycerol, and ketone body metabolism CPT1B; ACSF2; MED20; ACOT10; ACAD11; CCNC; ACOT2; MED6; AGT; ACOT9.1
    Metabolism CKMT2A; SLC25A14; PDK3B; DDAH2; PLB1; GLIPR1; AWAT2; GLB1L; GSTK1; NEU4
    Metabolism of lipids and lipoproteins AGPAT6; CYP4T8; ARF3; YAP1; LBR; COQ6; PIK3R6; ARSK; VAPB; ABHD4
    PPARA activates gene expression MED10; MED7; GRHL1; PLIN2; MED8; ANKRD1; CDK19; MED6; GLIPR1; MED16
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED9; CTGF; CDK19; MED20; MED7; PLIN2; MED18; MED23; MED22; MED29
    Transcriptional regulation of white adipocyte differentiation MED22; MED29; EGR2; MED21; NR2F2; EBF1; MED19; MED18; MED9; CDK19

    MED18 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED18 itself. We selected most functions MED18 had, and list some proteins which have the same functions with MED18. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity CRSP7; MDT-19; PPRC1; PPARGC1B; MED17; MED10; MED22; THRAP3; MED9; MED19
    protein binding SPG7; TAF2; PCDH17; SDCBP2; EPS15; LONRF3; PPIB; MEP1A; RPAP1; ACD

    MED18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED18 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED18.

    MED10; MED29; Med20; MED19

    Wu, CB; Sakorafas, P; et al. IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. JOURNAL OF IMMUNOLOGY 170:5571-5577(2003).

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