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MED18

  • Official Full Name

    mediator complex subunit 18

  • Overview

    MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate;transcription via RNA polymerase II (Sato et al., 2003 (PubMed 12584197)).
  • Synonyms

    MED18; mediator complex subunit 18; mediator of RNA polymerase II transcription, subunit 18 homolog (S. cerevisiae); mediator of RNA polymerase II transcription subunit 18; FLJ20045; p28b; Human Mediator of RNA Polymerase II Transcription; hMED 18; hMED18; MED18_HUMAN; Mediator of RNA polymerase II transcription subunit 18 homolog; OTTHUMP00000003645; TRAP/mediator complex subunit p28b; mediator of RNA polymerase II transcription, subunit 18 homolog;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MED18-805H Recombinant Human MED18, GST-tagged E.coli GST 1-208aa
Human MED18-65H Recombinant Human MED18 protein, His-tagged E.coli His 223aa(including fusion tag)
Human MED18-1073HCL Recombinant Human MED18 cell lysate N/A
Human MED18-3848H Recombinant Human MED18 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MED18-3449H Recombinant Human MED18 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MED18-6212HF Recombinant Full Length Human MED18 Protein, GST-tagged In Vitro Cell Free System GST 208 amino acids
Human MED18-4475H Recombinant Human MED18 Protein, GST-tagged Wheat Germ GST
Human MED18-2017HFL Recombinant Full Length Human MED18 Protein, C-Flag-tagged Mammalian cells Flag
Human MED18-1391H-B Recombinant Human MED18 Protein Pre-coupled Magnetic Beads HEK293
Human MED18-1391H Recombinant Human MED18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MED18-9690M Recombinant Mouse MED18 Protein Mammalian Cell His
Mouse Med18-4014M Recombinant Mouse Med18 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MED18-5448M-B Recombinant Mouse MED18 Protein Pre-coupled Magnetic Beads HEK293
Mouse MED18-5448M Recombinant Mouse MED18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MED18-10659Z Recombinant Zebrafish MED18 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MED18 Related Articles

MED18 involved in several pathways and played different roles in them. We selected most pathways MED18 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyNRP1A;DRAP1;FGF8B;EFNA1;CEBPA;LGI4;MED16;SEMA3AB;CLASP1
Fatty acid, triacylglycerol, and ketone body metabolismACOT11;ACOT9.1;ANKRD1;ACOT13;CCNC;MED20;ABCA1;TIAM2;ACOT9
MetabolismNUBP1;BRP44;THEM5;SLC5A4;AZIN1A;ABHD3;CLPS;FA2H;CYP24A1
Metabolism of lipids and lipoproteinsCERS3B;MED20;SUMF2;ARSH;CPT2;CPNE7;LPA;PTPMT1;GGTLC1
PPARA activates gene expressionMED8;MED9;PLIN2;TIAM2;MED19;MED15;CTGF;MED6;MED31
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)CDK19;MED9;MED23;G0S2;MED7;PLIN2;MED22;MED31;MED16
Transcriptional regulation of white adipocyte differentiationMED19;NR2F2;MED18;MED22;EBF1;EGR2;MED29;CDK19;MED21

MED18 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED18 itself. We selected most functions MED18 had, and list some proteins which have the same functions with MED18. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription cofactor activityMED22;FOXH1;MED8;MED19;MED18;MED7;MED11;MED1;MED31
protein bindingSH3GL1;TUBGCP2;KAT6B;HAT1;MTPAP;STAM2;BCL11A;DMD;DVL1

MED18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED18 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED18.

MED10; MED29; Med20; MED19

Wu, CB; Sakorafas, P; et al. IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction. JOURNAL OF IMMUNOLOGY 170:5571-5577(2003).
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