med20
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  • Official Full Name
  • mediator complex subunit 20
  • Background
  • MED20 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with;DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al.,;2003 (PubMed 14576168)).
  • Synonyms
  • MED20; mediator complex subunit 20; Trf (TATA binding protein related factor) proximal homolog (Drosophila) , TRFP; mediator of RNA polymerase II transcription subunit 20; DKFZp586D2223; PRO0213; TRF proximal protein homolog; TRFP; hTRFP; TRF-proximal protein homolog; Trf (TATA binding protein-related factor)-proximal homolog
Cat.#:MED20-7073HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant HumanMED20, His-tagged
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Cat.#:MED20-9692MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MED20 Protein
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Cat.#:MED20-3635RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MED20 Protein
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Cat.#:MED20-684CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MED20 Protein, His-tagged
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Cat.#:MED20-1471CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MED20
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Cat.#:MED20-1013ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MED20
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Cat.#:MED20-4389HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MED20 293 Cell Lysate
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Involved Pathway

MED20 involved in several pathways and played different roles in them. We selected most pathways MED20 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED20 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Developmental Biology
DPYSL2B; MYL12A; ARHGEF28; NKX2.2A; CACNG8A; KIF4A; SEMA3A; NR5A1; COL9A1; DPYSL2
Fatty acid, triacylglycerol, and ketone body metabolism
Agmo; AGT; CTGF; CDK8; PPARGC1B; ECI1; SIN3B; DECR1; DGAT1B; ACOT9.1
Gene Expression
ZKSCAN4; FKBP6; ZNF230; ZFP30; ADAR; SF3A1; KRBA1; ZNF554; BRF1B; LBH
Generic Transcription Pathway
ZKSCAN3; NR2C2AP; ZNF668; ZNF223; NR1D2A; MED8; ZNF560; ZNF500; ZNF664; ZNF680
Metabolism
APOA4B.2; UGT1B1; ELA2L; CA13; SLC25A12; OSBP; SLC6A12; CYP46A1; CYP11B1; ACOT9
Metabolism of lipids and lipoproteins
FAM213B; PLBD1; SLC27A2; ARSK; APOA4B.1; BCHE; GRHL1; PPM1LB; GLTPA; APOA5
PPARA activates gene expression
SREBF2; MED22; MED19; MED21; APOA5; MED31; TIAM2; MED9; PLIN2; MED16
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
MED19; ANKRD1; GLIPR1; MED20; G0S2; MED31; PLIN2; MED6; MED29; MED21

Protein Function

MED20 has several biochemical functions, for example, DNA-directed RNA polymerase activity, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED20 itself. We selected most functions MED20 had, and list some proteins which have the same functions with MED20. You can find most of the proteins on our site.
Function
Related Protein
Function DNA-directed RNA polymerase activity
Related Protein POLR2A; POLR2GL; POLR1C; CD3EAP; POLR3C; POLR3H; RPAP1; POLR3G; POLR2D; POLR2E
Function RNA polymerase II transcription cofactor activity
Related Protein MED17; MED31; PPRC1; MED13; TDG; MED18; MED26; PPARGC1A; CNOT2; MED1
Function protein binding
Related Protein PSEN1; YEATS4; TBC1D17; RGR; PLEKHB1; STAG2; SMAD5; NR4A1; EIF3L; ANKS1A
Function transcription coactivator activity
Related Protein TDRD3; GRIP1; MAX; TAF10; NCOA4; ATXN7L3; GTF2A2; CCAR1; TAF7L; SOX10
Function ubiquitin protein ligase activity
Related Protein FBXL22; UBE2T; SIAH1A; FBXO40; ZSWIM2; AMFR; UBE2G1A; UBE2Z; ARIH1L; WWP2

Interacting Protein

MED20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED20 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED20.
MED10; MED29; MED19; MED18; CDK19