|Official Full Name||mediator complex subunit 21|
|Background||It recognizes human SRB7, an essential component of SRB7/MED-containing cofactor complex (SMCC). This complex associates with the RNA polymerase II holoenzyme through SRB7 to enhance the gene-specific activation or repression induced by DNA-binding transcription factors.|
|Synonyms||MED21; mediator complex subunit 21; SRB7; SURB7; mediator of RNA polymerase II transcription subunit 21; hSrb7; RNAPII complex component SRB7; RNA polymerase II complex component SRB7; RNA polymerase II holoenzyme component SRB7; SRB7 suppressor of RNA polymerase B homolog; SRB7 suppressor of RNA polymerase B homolog (yeast); SRB7 (suppressor of RNA polymerase B, yeast) homolog; OTTHUMP00000240653; OTTHUMP00000240654|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MED21 involved in several pathways and played different roles in them. We selected most pathways MED21 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Developmental Biology||SCN8A; COL9A3; EFNB2A; EFNB2; SALL4; EZRA; MYL12A; GFRA1; LGI3; TCF12|
|Fatty acid, triacylglycerol, and ketone body metabolism||GLIPR1; AGT; PPARGC1B; ACSF3; CTGF; AGPAT1; ACOT6; ACOT11; ACOT9; MTF1|
|Metabolism||SLC35D1A; SLC27A2A; CPNE3; DBH; CSPG5B; CYP2U1; PAICS; DPYD; VAPB; APOC2|
|Metabolism of lipids and lipoproteins||MED10; PLBD1; FABP9; DGAT1B; CYP4F11; ACOT8; ACOT11; CERS3B; APOEB; ACOT2|
|PPARA activates gene expression||MED21; MED7; MED15; CDK19; MED8; TIAM2; PLIN2; MED16; MED6; MED26|
|Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)||MED26; MED7; CTGF; MED25; ANKRD1; GLIPR1; MED6; MED20; PLIN2; MTF1|
|Transcriptional regulation of white adipocyte differentiation||EGR2; MED19; EBF1; MED18; MED21; MED22; CDK19; NR2F2; MED29; MED9|
MED21 has several biochemical functions, for example, DNA-directed RNA polymerase activity, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED21 itself. We selected most functions MED21 had, and list some proteins which have the same functions with MED21. You can find most of the proteins on our site.
|DNA-directed RNA polymerase activity||POLR2E; POLR3G; CCDC111; POLR1C; CD3EAP; POLR2B; POLR3B; POLR3A; POLR2M; RPAP1|
|RNA polymerase II transcription cofactor activity||MED8; CNOT2; NKX2; MED13B; MED20; MED7; MED17; MED13; MED30; TDG|
|protein binding||SRSF5; IRAK1BP1; ADCY6; TMSB10; C1orf38; DLG1; PPP1R16A; CMTM3; FAM184A; GATA1|
|transcription coactivator activity||TUBB3; RBPMS; PIAS1; JUPA; MKL1B; MED31; NFATC4; BRDT; CITED1; ARNT|
|ubiquitin protein ligase activity||RNF2; RNF4; UBE2N; TRIM37; HERC2; UBE2U; TRIM6; UBE2NB; UBE3C; PDZRN3|
MED21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED21 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED21.
MED10; MED9; MED19; MED26; SSC5D; MAGEB4