MED21 Protein, mediator complex subunit 21

MED21

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MED21

Official Full Name mediator complex subunit 21
Background It recognizes human SRB7, an essential component of SRB7/MED-containing cofactor complex (SMCC). This complex associates with the RNA polymerase II holoenzyme through SRB7 to enhance the gene-specific activation or repression induced by DNA-binding transcription factors.
Synonyms MED21; mediator complex subunit 21; SRB7; SURB7; mediator of RNA polymerase II transcription subunit 21; hSrb7; RNAPII complex component SRB7; RNA polymerase II complex component SRB7; RNA polymerase II holoenzyme component SRB7; SRB7 suppressor of RNA polymerase B homolog; SRB7 suppressor of RNA polymerase B homolog (yeast); SRB7 (suppressor of RNA polymerase B, yeast) homolog; OTTHUMP00000240653; OTTHUMP00000240654
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Med21-360M Recombinant Mouse Med21 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human MED21-4388HCL Recombinant Human MED21 293 Cell Lysate HEK293 N/A
    Human MED21-7607H Recombinant Human MED21, His-tagged E.coli N/A
    Human MED21-807H Recombinant Human MED21, GST-tagged E.coli GST
    Rhesus Macaque MED21-2720R Recombinant Rhesus monkey MED21 Protein, His-tagged Mammalian Cell His
    Zebrafish MED21-12595Z Recombinant Zebrafish MED21 Mammalian Cell His

    MED21 involved in several pathways and played different roles in them. We selected most pathways MED21 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology SCN8A; COL9A3; EFNB2A; EFNB2; SALL4; EZRA; MYL12A; GFRA1; LGI3; TCF12
    Fatty acid, triacylglycerol, and ketone body metabolism GLIPR1; AGT; PPARGC1B; ACSF3; CTGF; AGPAT1; ACOT6; ACOT11; ACOT9; MTF1
    Metabolism SLC35D1A; SLC27A2A; CPNE3; DBH; CSPG5B; CYP2U1; PAICS; DPYD; VAPB; APOC2
    Metabolism of lipids and lipoproteins MED10; PLBD1; FABP9; DGAT1B; CYP4F11; ACOT8; ACOT11; CERS3B; APOEB; ACOT2
    PPARA activates gene expression MED21; MED7; MED15; CDK19; MED8; TIAM2; PLIN2; MED16; MED6; MED26
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) MED26; MED7; CTGF; MED25; ANKRD1; GLIPR1; MED6; MED20; PLIN2; MTF1
    Transcriptional regulation of white adipocyte differentiation EGR2; MED19; EBF1; MED18; MED21; MED22; CDK19; NR2F2; MED29; MED9

    MED21 has several biochemical functions, for example, DNA-directed RNA polymerase activity, RNA polymerase II transcription cofactor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED21 itself. We selected most functions MED21 had, and list some proteins which have the same functions with MED21. You can find most of the proteins on our site.

    Function Related Protein
    DNA-directed RNA polymerase activity POLR2E; POLR3G; CCDC111; POLR1C; CD3EAP; POLR2B; POLR3B; POLR3A; POLR2M; RPAP1
    RNA polymerase II transcription cofactor activity MED8; CNOT2; NKX2; MED13B; MED20; MED7; MED17; MED13; MED30; TDG
    protein binding SRSF5; IRAK1BP1; ADCY6; TMSB10; C1orf38; DLG1; PPP1R16A; CMTM3; FAM184A; GATA1
    transcription coactivator activity TUBB3; RBPMS; PIAS1; JUPA; MKL1B; MED31; NFATC4; BRDT; CITED1; ARNT
    ubiquitin protein ligase activity RNF2; RNF4; UBE2N; TRIM37; HERC2; UBE2U; TRIM6; UBE2NB; UBE3C; PDZRN3

    MED21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED21 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED21.

    MED10; MED9; MED19; MED26; SSC5D; MAGEB4

    Tebbji, F; Chen, YL; et al. A Functional Portrait of Med7 and the Mediator Complex in Candida albicans. PLOS GENETICS 10:-(2014).
    Shaikhibrahim, Z; Offermann, A; et al. MED12 overexpression is a frequent event in castration-resistant prostate cancer. ENDOCRINE-RELATED CANCER 21:663-675(2014).

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