mlh3
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  • Official Full Name
  • mutL homolog 3 (E. coli)
  • Background
  • This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
  • Synonyms
  • MLH3; mutL homolog 3 (E. coli); mutL (E. coli) homolog 3; DNA mismatch repair protein Mlh3; HNPCC 7; HNPCC; HNPCC7; MGC138372; Mismatch repair gene MLH 3; mismatch repair gene MLH3; MLH 3; MutL homolog 3; MutL protein homolog 3; S240II117
Cat.#:MLH3-2782RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MLH3 Protein, His-tagged
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Cat.#:MLH3-4294HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MLH3 293 Cell Lysate
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Involved Pathway

MLH3 involved in several pathways and played different roles in them. We selected most pathways MLH3 participated on our site, such as Mismatch repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mismatch repair
RFC5; RPA3; POLD4; EXO1; MSH2; LIG1; SSBP1; PCNA; MSH6; MSH3

Protein Function

MLH3 has several biochemical functions, for example, ATP binding, ATPase activity, centromeric DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLH3 itself. We selected most functions MLH3 had, and list some proteins which have the same functions with MLH3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DGKA; ORC1L; KIF6; MYO5A; TTLL1; MAP3K3; AKT1; TTBK1; PYGL; RFC2
Function ATPase activity
Related Protein INO80; ATP13A; ABCB4; ATAD2B; KIFC3; KIF23; KIF27; PSMC2; ABCB6A; ERCC3
Function centromeric DNA binding
Related Protein MSH3; CENPC1; MLH3; KIF2C; MSH2; CENPB; ZW10
Function chromatin binding
Related Protein MEN1; RBPJL; CDK9; GLI3; PROP1; CRTC2; SIRT6; MNT; TRP63; RERE
Function mismatched DNA binding
Related Protein TDG; MLH1; MLH3; MSH4; MSH6; MSH5; PMS1
Function protein binding
Related Protein STX12; LSAMP; ZNF202; MIS18BP1; SLPI; MPZL2; XPO1; STRAP; PRR3; XPA
Function satellite DNA binding
Related Protein MLH3; CENPB; MBD4
Function single-stranded DNA binding
Related Protein RAD51L3; MCM6; BRCA2; MEIOB; NEIL3; DMC1; SUB1; HNRNPK; OBFC2B; RAD51D

Interacting Protein

MLH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLH3.
FBP2; DVL1; CDC14B; CTSV; FRAT2; HRAS; TGFB1; ALDOB; FBP1; IGFBP3; RASA1; XPA; TMOD1; AKT1; HSD17B3; CDK8; STX17; SEC61B; PPP2CB; FANCC