MLL

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MLL

Official Full Name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
Background This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.
Synonyms MLL; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog); histone-lysine N-methyltransferase MLL; ALL 1; CXXC7; HRX; HTRX1; KMT2A; MLL1A; TRX1; trithorax-l
 
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MLL involved in several pathways and played different roles in them. We selected most pathways MLL participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

MLL has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by MLL itself. We selected most functions MLL had, and list some proteins which have the same functions with MLL. You can find most of the proteins on our site.

Function Related Protein

MLL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLL here. Most of them are supplied by our site. Hope this information will be useful for your research of MLL.

Bardini, M; Woll, PS; et al. Clonal variegation and dynamic competition of leukemia-initiating cells in infant acute lymphoblastic leukemia with MLL rearrangement. LEUKEMIA 29:38-50(2015).
Yamamoto, H; Watanabe, Y; et al. An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa. WORLD JOURNAL OF GASTROENTEROLOGY 20:3927-3937(2014).

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