mll2
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  • Official Full Name
  • myeloid/lymphoid or mixed-lineage leukemia 2
  • Background
  • The protein encoded by this gene is a histone methyltransferase that methylates the Lys-4 position of histone H3. The encoded protein is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.
  • Synonyms
  • MLL2; myeloid/lymphoid or mixed-lineage leukemia 2; TNRC21, trinucleotide repeat containing 21; histone-lysine N-methyltransferase MLL2; ALR; CAGL114; KMT2D; MLL4; ALL1 related gene; Myeloid/lymphoid or mixed lineage leukemia 2; ALL1-related protein; Kabuki make-up syndrome; lysine N-methyltransferase 2B; lysine N-methyltransferase 2D; Kabuki mental retardation syndrome; trinucleotide repeat containing 21; KMS; AAD10; KMT2B; TNRC21
Cat.#:MLL2-190HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human MLL2 protein, GST-tagged, Active
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MLL2 Related Articles

LOSMAN, MJ; LEUNG, SO; et al. DEVELOPMENT AND EVALUATION OF THE SPECIFICITY OF A RAT MONOCLONAL ANTIIDIOTYPE ANTIBODY, WN, TO AN ANTI-B-CELL LYMPHOMA MONOCLONAL-ANTIBODY, LL2. CANCER RESEARCH 55:S5978-S5982(1995).
Leung, SO; Goldenberg, DM; et al. Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2. MOLECULAR IMMUNOLOGY 32:1413-1427(1995).
LEUNG, SO; SHEVITZ, J; et al. CHIMERIZATION OF LL2, A RAPIDLY INTERNALIZING ANTIBODY SPECIFIC FOR B-CELL LYMPHOMA. HYBRIDOMA 13:469-476(1994).