Name: Active Recombinant Human MLL2 protein, GST-tagged
SKU: MLL2-190H

Species :	Human
Source :	Insect Cells
Tag :	GST
Protein Length :	5317-end
Description :	Histone-lysine N-methyltransferase 2D, also known as mixed-lineage leukemia 2 (MLL2), methylates 'Lys-4' of histone H3 (H3K4me). Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2/KMT2D is among the most frequently mutated genes in a variety of pediatric tumors.
Form :	50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity :	2.5 nmol/min/mg
Molecular Mass :	51 kDa
Purity :	>80%
Applications :	Methyltransferase Assay
Stability :	1 year at -70 centigrade from the date of shipment
Storage :	Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration :	0.1μg/μl

Gene Name	MLL2 myeloid/lymphoid or mixed-lineage leukemia 2 [ Homo sapiens ]
Official Symbol	MLL2
Synonyms	MLL2; myeloid/lymphoid or mixed-lineage leukemia 2; TNRC21, trinucleotide repeat containing 21; histone-lysine N-methyltransferase MLL2; ALR; CAGL114; KMT2D; MLL4; ALL1-related protein; Kabuki make-up syndrome; lysine N-methyltransferase 2B; lysine N-meth
Gene ID	8085
mRNA Refseq	NM_003482
Protein Refseq	NP_003473
MIM	602113
UniProt ID	O14686
Chromosome Location	12q13.12
Pathway	Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function	DNA binding; histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; protein binding; transcription regulatory region DNA binding; transferase activity; zinc ion binding;