Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

MLXIPL

Official Full Name

MLX interacting protein-like
Overview

This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
Synonyms

MLXIPL; MLX interacting protein-like; WBSCR14, Williams Beuren syndrome chromosome region 14; carbohydrate-responsive element-binding protein; bHLHd14; carbohydrate response element binding protein; CHREBP; MIO; MONDOB; WS bHLH; Carbohydrate responsive element binding protein; Class D basic helix-loop-helix protein 14; MLX interacting protein like; Mlx interactor; MLX-interacting protein-like; WBS14_HUMAN; WBSCR 14; WBSCR14; Williams Beuren syndrome chromosome region 14; Williams Beuren syndrome chromosome region 14 protein; Williams-Beuren syndrome chromosomal region 14 protein; WS basic helix loop helix leucine zipper protein; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MLXIPL-2041H	Recombinant Human MLX Interacting Protein-Like, GST-tagged	E.coli	GST	Inquiry
Human	MLXIPL-111H	Recombinant Human MLXIPL, GST-tagged	Wheat Germ	GST	Inquiry
Chicken	MLXIPL-3773C	Recombinant Chicken MLXIPL	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
MLXIPL Related Articles

MLXIPL involved in several pathways and played different roles in them. We selected most pathways MLXIPL participated on our site, such as Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MLXIPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Insulin resistance	NFKBIAA;SLC27A2;PRKAG3B;TRIB3;STAT3;PTPN11B;G6PC3;PRKAA2;CRTC2
Non-alcoholic fatty liver disease (NAFLD)	SDHA;PIK3R5;IKBKB;NDUFA3;TGFB1;IL6;ADIPOR1;PIK3CA;NDUFB5

MLXIPL has several biochemical functions, for example, contributes_to DNA binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLXIPL itself. We selected most functions MLXIPL had, and list some proteins which have the same functions with MLXIPL. You can find most of the proteins on our site.

Function	Related Protein
contributes_to DNA binding	MCM7;MRE11A;ARNTL1A;TCF3;SMAD4;NFE2L2A;FOXH1;SMAD2;CLOCKA
DNA binding	CSDC2A;DUX3;ZFP518A;HMGXB3;MYCL1;NUFIP1;HIST1H2BC;RABGEF1;CERS4A
RNA polymerase II core promoter proximal region sequence-specific DNA binding	NFAT5;TFAM;SALL1;SMAD1;NEUROD1;PITX2;CDX4;SNAI3;ISL1
carbohydrate response element binding
protein heterodimerization activity	VAPB;YWHAE;SMAD2;UBXN6;KCNB1;HAND1;TCF4;MCL1;RBP4
NOT protein homodimerization activity	MLXIPL;MSH3;DDIT3;MSH6;EXT2;NUDT16L1;MECOM;MYO9B;KCNA3
transcription factor activity, sequence-specific DNA binding	PBX1B;SMAD2;RHOXF1;NFE2L2B;AFF4;FOXP2;ZBTB25;NEUROG1;FOXA2
transcription factor binding	HDAC1;CTNNB1;PPARG;INSIG2;GCM1;TBX5;SORBS3;RELA;JUNBA
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	DACH1;RELA;KLF16;CC2D1A;SALL1;SP3;GATA1;SREBF2;ASCL2

MLXIPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLXIPL here. Most of them are supplied by our site. Hope this information will be useful for your research of MLXIPL.

GRB2; MLX

Aung, LHH; Yin, RX; et al. Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels. SCIENTIFIC REPORTS 4:-(2014).

Seifi, M; Ghasemi, A; et al. Is C771G Polymorphism of MLX interacting protein-like (MLXIPL) Gene a Novel Genetic Risk Factor for Non-alcoholic Fatty Liver Disease?. CELLULAR AND MOLECULAR BIOLOGY 60:37-42(2014).