mlxipl
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  • Official Full Name
  • MLX interacting protein-like
  • Background
  • This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.
  • Synonyms
  • MLXIPL; MLX interacting protein-like; WBSCR14, Williams Beuren syndrome chromosome region 14; carbohydrate-responsive element-binding protein; bHLHd14; carbohydrate response element binding protein; CHREBP; MIO; MONDOB; WS bHLH; Carbohydrate responsive element binding protein; Class D basic helix-loop-helix protein 14; MLX interacting protein like; Mlx interactor; MLX-interacting protein-like; WBS14_HUMAN; WBSCR 14; WBSCR14; Williams Beuren syndrome chromosome region 14; Williams Beuren syndrome chromosome region 14 protein; Williams-Beuren syndrome chromosomal region 14 protein; WS basic helix loop helix leucine zipper protein; WS basic-helix-loop-helix leucine zipper protein; WS-bHLH; Williams-Beuren syndrome chromosome region 14 protein 1; Williams-Beuren syndrome chromosome region 14 protein 2
Cat.#:MLXIPL-111HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MLXIPL, GST-tagged
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Cat.#:MLXIPL-2041HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MLX Interacting Protein-Like, GST-tagged
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Cat.#:MLXIPL-3773CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MLXIPL
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Involved Pathway

MLXIPL involved in several pathways and played different roles in them. We selected most pathways MLXIPL participated on our site, such as Insulin resistance, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MLXIPL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Insulin resistance
SLC27A1B; PIK3R3A; CREB3L2; FOXO1B; NFKBIAB; PRKAG2; NR1H3; NOS3; PPP1R3DA; PPARGC1B
Non-alcoholic fatty liver disease (NAFLD)
NDUFS5; AKT1; BAX; GSK3B; FAS; NDUFB2; NDUFC2; IRS1; NDUFS2; Fasl

Protein Function

MLXIPL has several biochemical functions, for example, contributes_to DNA binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLXIPL itself. We selected most functions MLXIPL had, and list some proteins which have the same functions with MLXIPL. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to DNA binding
Related Protein MCM7; CLOCKA; SMAD4; RFC3; GTF3C4; GTF3C2; MAFGA; FOXH1; ARNTL1A; GTF3C3
Function DNA binding
Related Protein NKX3.3; DNAJB6; HIST1H2AE; MYRFL; E2F4; EEPD1; HOMEZA; KIN; H2AFB3; POU3F3A
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein BCL11B; TFAP2A; MYOG; HNRNPC; ZNF502; IRF1; CARF; TFAM; GATA4; HIST2H3A
Function carbohydrate response element binding
Related Protein MLXIPL
Function protein heterodimerization activity
Related Protein MICU1; SYCP3; TPD52L1; AXL; MYH7; BCL2L2; DMRTA2; H2AFB3; DMRT1; HIST1H2AM
Function NOT protein homodimerization activity
Related Protein MECOM; MSH6; EXT2; MSH3; NUDT16L1; MLXIPL; KCNA3; DDIT3; MYO9B
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF317; NFIL3-4; BCL6; FOXA; ZIC3; NR2F6B; SIM1; ZFP1; ALS2CR8; HLFA
Function transcription factor binding
Related Protein RELA; STK36; SP100; TBP; TFDP1A; EPN1; POU1F1; MECP2; HEYL; NLK
Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein NFIL3-2; REST; GZF1; NFATC2; MXD1; SKIL; BHLHE40; BCL11AA; BCL11AB; NR2E1

Interacting Protein

MLXIPL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLXIPL here. Most of them are supplied by our site. Hope this information will be useful for your research of MLXIPL.
GRB2; MLX

MLXIPL Related Articles

Aung, LHH; Yin, RX; et al. Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels. SCIENTIFIC REPORTS 4:-(2014).
Seifi, M; Ghasemi, A; et al. Is C771G Polymorphism of MLX interacting protein-like (MLXIPL) Gene a Novel Genetic Risk Factor for Non-alcoholic Fatty Liver Disease?. CELLULAR AND MOLECULAR BIOLOGY 60:37-42(2014).