MMP25 Protein, matrix metallopeptidase 25


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Official Full Name matrix metallopeptidase 25
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Synonyms MMP25; matrix metallopeptidase 25; MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6; matrix metalloproteinase-25; leukolysin; matrix metalloproteinase 20; matrix metalloproteinase 25; matrix metallopeptidase-like 1; matrix metalloproteinase-like 1; membrane-type 6 matrix metalloproteinase; membrane-type matrix metalloproteinase 6; membrane-type-6 matrix metalloproteinase;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MMP25-1775H Recombinant Human MMP25 protein, His-tagged E.coli His
    Mouse MMP25-9921M Recombinant Mouse MMP25 Protein Mammalian Cell His

    MMP25 involved in several pathways and played different roles in them. We selected most pathways MMP25 participated on our site, such as Matrix Metalloproteinases, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Matrix Metalloproteinases MMP11; MMP19; MMP12; TIMP2; MMP10; MMP15; MMP8; MMP26; MMP20; TIMP4

    MMP25 has several biochemical functions, for example, calcium ion binding, hydrolase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP25 itself. We selected most functions MMP25 had, and list some proteins which have the same functions with MMP25. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PLA2G4B; PROZ; MYL1; CD69; PRSS3; SPARC; CALM; EML1; CALB2B; CAPN3
    hydrolase activity SMG6; DUSP19B; F9A; UFSP2; TMPRSS11G; PTPREB; PRSS48; NT5DC3; SPO11; MEIOB
    metal ion binding PARP12B; ARFGAP3; CLCA3; LOXL2A; LATS2; TROVE2; Car8; ZBTB33; ZBTB10; METAP2A
    metalloendopeptidase activity MEP1A.2; UQCRC1; ADAM5P; C6AST3; ADAMTS18; SPG7; KEL; TLL1; ADAM10; ADAMTS15A
    metallopeptidase activity ADAM8; DNPEP; ERAP2; MEP1A.2; MMP2; ADAM9; ADAM8A; LNPEP; NPEPPS; C6AST4
    peptidase activator activity FN1; PCOLCE; CLPX; PSME4B; FBLN1; PCOLCE2; MMP25; APP; PINK1; PSME4
    peptidase activity CAPN5A; FAM105B; CTRC; ADAM1B; PLAUA; BMP1A; SOLH; SPINT1A; KLK1B11; F2RL1.2
    zinc ion binding BRF1A; FBXO11A; SHARPIN; FTR67; ADH8A; DPYS; ZNF205; RNF5; JADE3; ZBTB32

    MMP25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP25 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP25.

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