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FREM1

  • Official Full Name

    FRAS1 related extracellular matrix 1

  • Overview

    This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.
  • Synonyms

    FREM1; FRAS1 related extracellular matrix 1; C9orf154, chromosome 9 open reading frame 154; FRAS1-related extracellular matrix protein 1; C9orf143; C9orf145; DKFZp686M16108; FLJ25461; TILRR; BC037594; D630008K06; MOTA; BNAR; C9orf154; D430009N09; FREM 1; FREM1_HUMAN; Heb; Protein QBRICK; QBRICK; RGD1306981; RP11-265B7.2; RP23-410K19.1; extracellular matrix protein QBRICK;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FREM1-6138HCL Recombinant Human FREM1 293 Cell Lysate HEK293 N/A
Mouse Frem1-3083M Recombinant Mouse Frem1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FREM1 Related Articles
  • FREM1 Related Research Area

FREM1 involved in several pathways and played different roles in them. We selected most pathways FREM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FREM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

FREM1 has several biochemical functions, for example, carbohydrate binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FREM1 itself. We selected most functions FREM1 had, and list some proteins which have the same functions with FREM1. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingNOMO1;DGCR2;CLEC2D;LGALS7B;KLRC1;CLEC4M;CLEC10A;SIGLEC12;GALNT10
metal ion bindingMUL1B;ZNF131;PRG4B;COX5A;ALKBH5;Itgam&Itgb2;MMP1A;ADNP2A;SALL3B

FREM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FREM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FREM1.

Kohl, S; Hwang, DY; et al. Mild Recessive Mutations in Six Fraser Syndrome-Related Genes Cause Isolated Congenital Anomalies of the Kidney and Urinary Tract. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1917-1922(2014).
Richardson, RJ; Gebauer, JM; et al. AMACO Is a Component of the Basement Membrane-Associated Fraser Complex. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1313-1322(2014).
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