mtmr2
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  • Official Full Name
  • myotubularin related protein 2
  • Background
  • This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.
  • Synonyms
  • MTMR2; myotubularin related protein 2; CMT4B; myotubularin-related protein 2; KIAA1073; CMT4B1; MTMR2_HUMAN; OTTHUMP00000204445; OTTHUMP00000204446; OTTHUMP00000204447; OTTHUMP00000204448
Cat.#:MTMR2-5718HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MTMR2 Protein, GST-tagged
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Cat.#:MTMR2-1090HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTMR2, GST-tagged
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Cat.#:MTMR2-2902RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MTMR2 Protein, His-tagged
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Cat.#:MTMR2-3338CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MTMR2
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Cat.#:MTMR2-8948ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MTMR2
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Cat.#:MTMR2-4074HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MTMR2 293 Cell Lysate
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Cat.#:MTMR2-4075HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MTMR2 293 Cell Lysate
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Involved Pathway

MTMR2 involved in several pathways and played different roles in them. We selected most pathways MTMR2 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTMR2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PIKFYVE; IMPA2; PIP4K2C; PTENB; INPP5J; MTMR14; PIK3CA; PLD4; ITPK1A; NUDT4A
Metabolic pathways
POLE; SCP2A; GSTZ1; NDUFB3; CYP4A10; LPCAT1; NMRK1; FUT9A; COX11; HPDB
Phosphatidylinositol signaling system
PIK3R3A; CALM2A; IPMK; INPPL1A; PIP5K1B; PLCG1; INPP5B; IPPK; CDS1; IMPAD1

Protein Function

MTMR2 has several biochemical functions, for example, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity, phosphatidylinositol-3-phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTMR2 itself. We selected most functions MTMR2 had, and list some proteins which have the same functions with MTMR2. You can find most of the proteins on our site.
Function
Related Protein
Function phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Related Protein MTM1; SACM1LB; MTMR3; SACM1LA; PTPRQ; MTMR2; MTMR1B; NT5DC3; CTDSPL2A; SACM1L
Function phosphatidylinositol-3-phosphatase activity
Related Protein MTMR8; FIG4; MTMR14; PTEN; MTMR1A; MTMR1; SACM1L; MTM1; MTMR2; MTMR3
Function protein binding
Related Protein ZBED1; DEAF1; RIPPLY1; RPS6KA5; KTI12; UBXN1; ATP11C; LETM1; LGALS2; DYX1C1
Function protein homodimerization activity
Related Protein MYOM3; PDCD6; XBP1; CTBP1; DEM1; NUDT21; ADH5; HPRT1; CSF1R; GDF7
Function protein tyrosine phosphatase activity
Related Protein DUSP15; EVLA; SSH1; MTMR7; PTPN1; EPM2A; PTPRNA; MTMR6; DUSP26; PTPRF
Function protein tyrosine/serine/threonine phosphatase activity
Related Protein DUSP12; CDKN3; DUSP19A; DUSP5; DUSP1; DUSP14; DUSP19B; DUSP11; SACM1LA; DUSP4

Interacting Protein

MTMR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTMR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTMR2.
NEFL; MTMR12; q7ard3_yerpe; tcaA1; metQ