myo6
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  • Official Full Name
  • myosin VI
  • Background
  • This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss.
  • Synonyms
  • MYO6; myosin VI; deafness, autosomal recessive 37 , DFNA22, DFNB37; myosin-VI; KIAA0389; Deafness autosomal recessive 37; DFNA 22; DFNA22; DFNB 37; DFNB37; MYO 6; MYO6_HUMAN; Myosin 6; Myosin6; MyosinVI; Unconventional myosin-6
Cat.#:MYO6-5843HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYO6 Protein, GST-tagged
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Cat.#:MYO6-502HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MYO6
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Cat.#:MYO6-2927RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MYO6 Protein, His-tagged
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Cat.#:MYO6-6300CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYO6
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Cat.#:MYO6-4006HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MYO6 293 Cell Lysate
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Involved Pathway

MYO6 involved in several pathways and played different roles in them. We selected most pathways MYO6 participated on our site, such as Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gap junction degradation
MYO6B; DAB2; MYO6A; MYO6
Gap junction trafficking
MYO6; GJA4; GJB3; GJD3; GJB2; GJB5; MYO6A; MYO6B; GJC1; GJB4
Gap junction trafficking and regulation
GJA5; CX30.3; GJC1; GJB3; CX27.5; DAB2; GJB4; GJD3; GJB2; MYO6
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
PICK1; NSFB; AKAP5; CACNG3; CACNG2; MYO6; HAND2; GRIP1; NSFA
Membrane Trafficking
CLVS1; SNX9; GJC1; MYO1C; TRAPPC3; SEC16B; MCFD2; MYO6A; CX27.5; SCFD1
Neuronal System
KCNS3A; KCNA6A; CHRNE; STXBP1A; KCNS3; KCNMB2; KCNV2; KCNS2; HCN4; RAB3AB
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
DLG1L; HAND2; NSFB; CHRNA2; GABRR2A; CHRND; CAMKK1B; GRIP1; MYO6; CHRNA5
Stabilization and expansion of the E-cadherin adherens junction
KIFC3; LIMA1; MYO6; PLEKHA7; LPP

Protein Function

MYO6 has several biochemical functions, for example, ADP binding, ATP binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO6 itself. We selected most functions MYO6 had, and list some proteins which have the same functions with MYO6. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein ME1; P2RY1; MYH9; MIEF1; LONP1; PKM; PRKAG1; MYO18A; PRKAG2; MYO9B
Function ATP binding
Related Protein PHKG1; DCAKD; MKNK2B; SBK1; UCK2; MAP3K1; MARS; UBE2D2A; ITPKC; ABCB8
Function actin binding
Related Protein MED28; DAAM1B; WASF3; TAGLN; DIAPH1; MSRB1A; ALDOA; PHACTR3; EPS8L1; FSCN1A
Function actin filament binding
Related Protein TLN2A; AASS; FLNC; DBNLA; VPS16; FSCN1; CTNNAL1; DBNLB; VCLA; SHROOM3
Function calmodulin binding
Related Protein PHKG1; ITPKA; RGS4; CAMK2D1; PLCB3; RGS2; MARCKSB; KCNQ3; DCX; ATP2B1
Function minus-end directed microfilament motor activity
Related Protein MYO6
Function motor activity
Related Protein DYNLT3; DCTN1; KLC1; VMHCL; DYNC2LI1; MYO6; MYO6B; MYH6; MYO5A; KIF3C
Function protein binding
Related Protein PRMT6; ADRB2; S100A4; CLTA; PROM1; S100A16; CALD1; C9orf86; COMMD2; VPS54

Interacting Protein

MYO6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO6.
Dab2; DAB2; UBB; GIPC1; TNFRSF1A; TNFRSF1B; USP11; AP2B1; Dab1; IKBKE; MAP3K3; CYLD; USP25; RIPK3; IKBKG

MYO6 Related Articles

Zak, M; Bress, A; et al. Ergic2, a Brain Specific Interacting Partner of Otoferlin. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 29:941-948(2012).