MYO6
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Official Full Name
myosin VI -
Overview
This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss. -
Synonyms
MYO6;myosin VI;deafness, autosomal recessive 37 , DFNA22, DFNB37;myosin-VI;KIAA0389;Deafness autosomal recessive 37;DFNA 22;DFNA22;DFNB 37;DFNB37;MYO 6;MYO6_HUMAN;Myosin 6;Myosin6;MyosinVI;Unconventional myosin-6
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- Non
- Avi
- Fc
- DDK
- Myc
- GST
Involved Pathway
MYO6 involved in several pathways and played different roles in them. We selected most pathways MYO6 participated on our site, such as Gap junction degradation,Gap junction trafficking,Gap junction trafficking and regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | Apba1,SLC1A3A,KCNA2,BZRAP1,UNC13B,KCNF1,KCNN3,SYN2,ARL6IP5B,KCNF1A |
| Stabilization and expansion of the E-cadherin adherens junction | LPP,PLEKHA7,KIFC3,LIMA1 |
| Membrane Trafficking | TGOLN2,GOLGA2,TMED10,MYO6B,TRAPPC5,NSFB,CPD,TFR1B,CLVS2,CLVS1 |
| Gap junction trafficking | GJA8,MYO6A,MYO6B,GJA4,GJB5,GJB2,CX27.5,DAB2,GJD3,GJB7 |
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | PICK1,AKAP5,CHRNE,CHRNA2,NCALDA,CAMKK1B,DLG1L,CHRND,NSFB,GRIP1 |
| Gap junction degradation | MYO6B,MYO6A,DAB2 |
| Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | GRIP1,CACNG3,NSFB,PICK1,CACNG2,AKAP5,HAND2,NSFA |
| Gap junction trafficking and regulation | GJB3,GJA4,GJA5,MYO6B,GJB2,GJA8,GJD3,MYO6A,DAB2,GJB7 |
Protein Function
MYO6 has several biochemical functions, for example, ADP binding,ATP binding,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO6 itself. We selected most functions MYO6 had, and list some proteins which have the same functions with MYO6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TOP2B,ATP1A4,ILK,HNRNPU,HK3,ATRX,KIF27,PRPS1,SCYL3,Ckmm |
| actin binding | HIP1RB,WASF2,SYNPO2L,ANTXR2A,MTSS1L,FGD4,ARPC5L,SLC4A1,FBXO25,PLECA |
| motor activity | DYNLT1,MYH9,MYHZ2,MYL6B,SMYHC3,KIF5A,MYHZ1.1,MYO7A,KIF1C,DYNC1I1 |
| calmodulin binding | NOS3,PATE4,PHKG1A,KCNN4,CAMK2G,IQCB1,RASGRF2,MYO5A,RRAD,MYH1B |
| actin filament binding | SYNE3,CAPZB,WIPF3,NEXN,EZR,PPP1R9B,CTNNA1,MYO7A,DBNLA,MYH3 |
| protein binding | STMN1,PRF1,TSPAN15,ACO1,UBE2E1,ZBTB43,IL4R,MED8,ANKRD27,NAPA |
| ADP binding | MYO7A,ABCG1,PRPS1,CHORDC1,ERN1,PRPS2,MYO9B,VCP,PRKAG1,ATP1A1 |
Interacting Protein
MYO6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO6.
Dab2;DAB2;UBB;GIPC1;TNFRSF1A;TNFRSF1B;USP11;AP2B1;Dab1;IKBKE;MAP3K3;CYLD;USP25;RIPK3;IKBKG
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References
- Zak, M; Bress, A; et al. Ergic2, a Brain Specific Interacting Partner of Otoferlin. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 29:941-948(2012).
