myo6
Share
  • Official Full Name
  • myosin VI
  • Background
  • This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss.
  • Synonyms
  • MYO6; myosin VI; deafness, autosomal recessive 37 , DFNA22, DFNB37; myosin-VI; KIAA0389; Deafness autosomal recessive 37; DFNA 22; DFNA22; DFNB 37; DFNB37; MYO 6; MYO6_HUMAN; Myosin 6; Myosin6; MyosinVI; Unconventional myosin-6
Cat.#:MYO6-5843HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYO6 Protein, GST-tagged
+Inquiry
Cat.#:MYO6-502HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MYO6
+Inquiry
Cat.#:MYO6-2927RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MYO6 Protein, His-tagged
+Inquiry
Cat.#:MYO6-6300CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYO6
+Inquiry
Cat.#:MYO6-4006HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MYO6 293 Cell Lysate
+Inquiry

Involved Pathway

MYO6 involved in several pathways and played different roles in them. We selected most pathways MYO6 participated on our site, such as Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYO6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gap junction degradation
DAB2; MYO6A; MYO6; MYO6B
Gap junction trafficking
GJA8; GJB3; CX27.5; GJC1; DAB2; CX30.3; GJB4; GJB7; MYO6; GJB2
Gap junction trafficking and regulation
DAB2; GJA8; GJB7; CX27.5; MYO6A; MYO6; GJC1; GJB2; GJA5; GJD3
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
CACNG3; NSFA; MYO6; PICK1; AKAP5; NSFB; GRIP1; HAND2; CACNG2
Membrane Trafficking
DTNBP1B; CNIH2; SNAPIN; SEC23IP; EXOC3; TRAPPC1; GOLGA2; PICALM; TMED10; SNF8
Neuronal System
KCNH8; KCNJ1A.1; KCNMB2; CHRNB4; GLS2B; KCNG3; RAB3AA; KCNJ1A.2; KCNAB3; KCNQ3
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
CHRND; HAND2; PICK1; CHRNA5; NCALDA; CHRNE; NSFB; MYO6; NSFA; CHRNA2
Stabilization and expansion of the E-cadherin adherens junction
PLEKHA7; KIFC3; MYO6; LIMA1; LPP

Protein Function

MYO6 has several biochemical functions, for example, ADP binding, ATP binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYO6 itself. We selected most functions MYO6 had, and list some proteins which have the same functions with MYO6. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein ME1; MYO3A; PRPS2; PKM; PRPS1; CHORDC1; HSP104; ACTA1; APAF1; VCP
Function ATP binding
Related Protein SMYHC2; FYN; PSMC1A; NLRP9C; PARS2; GRK1A; MKKS; EPHA4; NPR1A; SMARCA4
Function actin binding
Related Protein ACTN3B; PACRG; LRRK2; CORO7; MYPN; SMYHC3; CAP2; MYH1B; TLN2A; CAPG
Function actin filament binding
Related Protein NEBL; CORO6; TAGLN3B; CORO2A; MYO6; FSCN2B; ADD1; SYNE1; MYO1D; TNNC1
Function calmodulin binding
Related Protein SNTB2; CAMKK2; ITPKA; PHKG2; KCNN1; PLCB3; ORAI1; RGS2; GM101; MARCKSL1A
Function minus-end directed microfilament motor activity
Related Protein MYO6
Function motor activity
Related Protein DCTN1; DNAIC2; KLC1; MYO1G; MYO1C; DYNC2LI1; MYO1F; MYH1E; VMHCL; MYL6
Function protein binding
Related Protein ZNF436; TRAP1; FIBCD1; C12orf68; CIB3; DARS2; GUCY1A3; UBA52; FGFR3; TAP2

Interacting Protein

MYO6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYO6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYO6.
Dab2; DAB2; UBB; GIPC1; TNFRSF1A; TNFRSF1B; USP11; AP2B1; Dab1; IKBKE; MAP3K3; CYLD; USP25; RIPK3; IKBKG

MYO6 Related Articles

Zak, M; Bress, A; et al. Ergic2, a Brain Specific Interacting Partner of Otoferlin. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 29:941-948(2012).