| Official Full Name | myeloid/lymphoid or mixed-lineage leukemia 1 |
| Background | Histone-lysine N-methyltransferase HRX is an enzyme that in humans is encoded by the MLL (ALL1) gene. MLL stands for Myeloid/Lymphoid, or Mixed-Lineage, Leukemia. |
| Synonyms | Mll1; myeloid/lymphoid or mixed-lineage leukemia 1; HRX; Mll; All1; ALL-1; Cxxc7; HTRX1; KMT2A; mKIAA4050; 6430520K01 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
Mll1 involved in several pathways and played different roles in them. We selected most pathways Mll1 participated on our site, such as Lysine degradation, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with Mll1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | SUV420H1; OGDHA; DOT1L; NSD1; C2orf34; COLGALT2; AGPHD1; EHHADH; SETD1BA; OGDH |
| Transcriptional misregulation in cancer | HIST1H3H; FCGR1A; ETV6; IGFBP3; PER2; TRP53; TAF15; LRP2BP; BCL2L1; PDGFA |
Mll1 has several biochemical functions, for example, DNA binding, chromatin binding, core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Mll1 itself. We selected most functions Mll1 had, and list some proteins which have the same functions with Mll1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZNF596; RC3H2; NKX1.2LB; NKX2-5; TAF12; DMC1; HOXD4A; POLR3B; ASCL1A; IRX2A |
| chromatin binding | POU2F1; JARID2; ELK1; TCF7; CNBPA; HESX1; TGIF1; KLHDC3; BAZ1B; RNF2 |
| core promoter sequence-specific DNA binding | NRIP1; REST; SOX1; CHD2; NR1D1; ZFHX3; MEOX1; TP53; GATA3; PRMT5 |
| histone methyltransferase activity (H3-K4 specific) | KMT2E; SMYD1B; SETMAR; ASH1L; WHSC1L1; WBP7; WDR82; MLL1; KMT2A; SETD3 |
| histone-lysine N-methyltransferase activity | PRDM2; EHMT1B; PRDM6; MLL5; KMT2A; SETD8B; SETD8A; SUV39H1; WBP7; EHMT1A |
| identical protein binding | SERPINA1D; PUF60; HSPB1; SF1; BCAT1; DCP1A; PACSIN2; RAD52; SIRT1; GM5077 |
| lysine-acetylated histone binding | BRD7; PSME4B; BRD4; MLL1; PHIP; BRD9; ATAD2B; CARM1; BAZ1B; BRD3 |
| metal ion binding | FGD5; SPRTN; ATP2A1L; CYP4F14; IRF2BP1; PDE4B; MUL1A; CYP2F2; PHYH; ZNF177 |
| methyltransferase activity | PMT; C20orf7; COMTA; THUMPD2; METTL10; METTL25; PRDM14; PRDM13; ALDH1L1; PCMTL |
| protein binding | HIST1H1C; RND3; EGR1; VASN; PC; LRRC47; HSD3B7; MYL12B; STX16; IGF2BP1 |
| protein homodimerization activity | AXIN1; FLT3LG; ZBTB1; APOBEC3G; MZF1; DGAT2; SLC51A; HIF1AN; USH2A; MCL1 |
| transcription regulatory region DNA binding | CARM1; SMAD3; TCF7L1B; TBL1X; SMARCA2; BCOR; NR1D1; SALL2; JUN; CDK9 |
| transferase activity | KMT2A; GKUP; SETD1B; ADKA; EHMT1A; MAPK8A; METTL21A; ZDHHC1; UGT2A5; BST1 |
| unmethylated CpG binding | DNMT3B; KDM2A; CXXC1; DNMT3A; MLL1 |
| zinc ion binding | TRAF6; ZDHHC3A; TAF15; SETMAR; PPARG; RNF19B; TAF3; MMP7; CRIP1; RNF215 |
Mll1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Mll1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Mll1.
siglecg_mouse_gene; Rbbp5
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