nck2
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  • Official Full Name
  • NCK adaptor protein 2
  • Background
  • This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms
  • NCK2; NCK adaptor protein 2; cytoplasmic protein NCK2; NCKbeta; SH2/SH3 adaptor protein NCK-beta; growth factor receptor-bound protein 4; noncatalytic region of tyrosine kinase, beta; GRB4
Cat.#:NCK2-49HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NCK Adaptor Protein 2
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Cat.#:NCK2-15879HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NCK2, His-tagged
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Cat.#:NCK2-29113THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NCK2, His-tagged
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Cat.#:NCK2-10471MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NCK2 Protein
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Cat.#:NCK2-2511CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NCK2
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Cat.#:NCK2-3945HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NCK2 293 Cell Lysate
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Cat.#:NCK2-3946HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NCK2 293 Cell Lysate
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Involved Pathway

NCK2 involved in several pathways and played different roles in them. We selected most pathways NCK2 participated on our site, such as ErbB signaling pathway, Axon guidance, T cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCK2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
MAP2K4; HRASA; SHC3; AKT2L; MAPK3; GRB2; MAPK8B; ERBB2; CBL; ERBB4
Axon guidance
RAC1; EPHB4A; RASGEF1A; ROCK2; PPP3CC; GFRA4; KCNQ2; HRAS; PAK6; SRGAP1
T cell receptor signaling pathway
CD8A; KRAS; MUC1; SOS1; NCK1; MAP2K1; MAPK13; NFKBIB; AKT2; GSK3B
Pathogenic Escherichia coli infection
LY96; HCLS1; TLR4; EZR; TUBA3C; TUBA1C; TUBB1; TUBB7P; FYN; CD14

Protein Function

NCK2 has several biochemical functions, for example, SH3/SH2 adaptor activity, cytoskeletal adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCK2 itself. We selected most functions NCK2 had, and list some proteins which have the same functions with NCK2. You can find most of the proteins on our site.
Function
Related Protein
Function SH3/SH2 adaptor activity
Related Protein EPS8; NCK1; ITSN2; SOCS2; STAP1; SH3BP2; GRB10; GRB14; STAM; GRAP
Function cytoskeletal adaptor activity
Related Protein BAIAP2A; BIN3; BAIAP2; BICD1; BAIAP2L1B; BAIAP2L1A; ABI2; BAIAP2L1; SORBS2; ANK1
Function protein binding
Related Protein FAM3C; PIK3CB; MSLN; EIF4E; ILF3; IL1RAPL1; PEX5; LGR6; LNX2; PLEKHA2
Function protein complex binding
Related Protein ABP1; SLC25A3; MTHFR; STK11; RPH3A; CAPG; CCNE1; NFKBIA; PTCH1; PEX26
Function receptor signaling complex scaffold activity
Related Protein CD3E; GRIP1; CARD10; AXIN1; RGS14; ROPN1B; NCK2; MAGI2; GRIP2A; LDLRAP1
Function scaffold protein binding
Related Protein NLRP1; P2RY1; SHANK3; NOS3; GRIN2A; TREM2; CAV2; DLG4; ADCY6; IKBKB

Interacting Protein

NCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCK2.
RHOU; CHN1; PAK1; CBLB