NCK2

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NCK2

Official Full Name NCK adaptor protein 2
Background This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms NCK2; NCK adaptor protein 2; cytoplasmic protein NCK2; NCKbeta; SH2/SH3 adaptor protein NCK-beta; growth factor receptor-bound protein 4; noncatalytic region of tyrosine kinase, beta; GRB4
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NCK2-15879H Recombinant Human NCK2, His-tagged E.coli His
    Human NCK2-29113TH Recombinant Human NCK2, His-tagged E.coli His
    Human NCK2-3945HCL Recombinant Human NCK2 293 Cell Lysate HEK293 N/A
    Human NCK2-3946HCL Recombinant Human NCK2 293 Cell Lysate HEK293 N/A
    Human NCK2-49H Recombinant Human NCK Adaptor Protein 2 E.coli N/A
    Mouse NCK2-10471M Recombinant Mouse NCK2 Protein Mammalian Cell His
    Chicken NCK2-2511C Recombinant Chicken NCK2 Mammalian Cell His

    NCK2 involved in several pathways and played different roles in them. We selected most pathways NCK2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway CAMK2D1; SHC1; NRG2; RPS6KB1; HRAS; BAD; NCK2A; PIK3CB; ELK1; AREG
    Axon guidance SEMA6D; DUSP6; NCK1; NFATC2; KRAS; SCN3A; DCX; SEMA3G; ROCK2; MAPK1
    T cell receptor signaling pathway CD3E; CD3D; RHOA; MAPK13; PDCD1; IKBKG; PIK3CG; NCK2; CD28; NFKB1; CBLC
    Pathogenic Escherichia coli infection WASL; NCK2; TUBB6; ARPC5L; TUBB2B; CTTN; EZR; TLR4; FYN; ROCK1

    NCK2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by NCK2 itself. We selected most functions NCK2 had, and list some proteins which have the same functions with NCK2. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activity CNTNAP1; SH2D1A; IRS4; TOB1; BLNK; GRB14; STAP1; NCK2; SHB; SLA
    cytoskeletal adaptor activity NCK1; GAS2L2; BAIAP2A; BAIAP2L1A; SORBS2; BAIAP2L1; COX4I2; GAS2L1; BAIAP2L2; SDCBP
    protein binding RNF24; HMGB4; GTF2E2; VIM; CXXC1; CST2; ATXN7L3; FAM127C; ENOX1; GNA14
    protein complex binding SIX2; C8B; CYFIP1; RANBP2; SLC27A5; KAT6B; HTR2A; PPARA; CCND1; DRD1A
    receptor signaling complex scaffold activity NUP62; SHANK1; RGS14; AXIN1; DEDD2; MMS19; NCK2; G3BP2; MAGI2; NCK1
    scaffold protein binding NLGN4X; NLGN3; KCNA5; KRT15; KCNQ1; DLG4; NOS1; CACNA1G; CAV2; PANX1

    NCK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCK2.

    RHOU; CHN1; PAK1; CBLB

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