ncor1
Share
  • Official Full Name
  • nuclear receptor corepressor 1
  • Background
  • The most well characterized nuclear receptor corepressors are SMRT (silencing mediator for retinoic acid and thyroid hormone receptors) and its close paralog NCoR1 (nuclear receptor corepressor). NCoR1 functions to transcriptionally silence various unliga
  • Synonyms
  • NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1; nuclear receptor co-repressor 1; thyroid hormone- and reti
Cat.#:NCOR1-16HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human NCOR1/HDAC3 Protein, GST-tagged
+Inquiry
Cat.#:NCOR1-1705HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NCOR1 protein, His & T7-tagged
+Inquiry
Cat.#:NCOR1-28430THTag:Flag
Source (Host):Species:Human
Product nameRecombinant Human NCOR1, FLAG-tagged
+Inquiry
Cat.#:NCOR1-8484HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human NCOR1, His-tagged
+Inquiry
Cat.#:Ncor1-1706MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ncor1 protein, His & T7-tagged
+Inquiry
Cat.#:NCOR1-10610ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NCOR1
+Inquiry

Involved Pathway

NCOR1 involved in several pathways and played different roles in them. We selected most pathways NCOR1 participated on our site, such as Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Thyroid hormone signaling pathway
MED13; TRP53; PIK3R3; MAP2K2; BAD; MAPK3; PRKCB; KAT2B; NCOA1; MED24
Transcriptional misregulation in cancer
HIST1H3D; PDGFA; HOXA10; ITGAM; ETV4; HIST1H3C; ATM; BCL2L1; Aff1; HIST1H3I

Protein Function

NCOR1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, histone deacetylase binding, histone deacetylase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOR1 itself. We selected most functions NCOR1 had, and list some proteins which have the same functions with NCOR1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II activating transcription factor binding
Related Protein LDB1; BHLHE40; NEUROD1; ATF2; BEX1; NFE2L2; ZFPM1; HNF4A; IFI27; NCOR1
Function histone deacetylase binding
Related Protein SP2; RELA; TOP2B; NR2E1; SFPQ; NR2C1; MYOCD; MEF2A; ZFP932; HIF1A
Function histone deacetylase regulator activity
Related Protein TP53; MAPK8; NCOR1; TRP53
Function ligand-dependent nuclear receptor binding
Related Protein MED1; NCOR2; BAZ2A; SMARCE1; ARID1A; PROX1; UBA3; NCOA3; ISL1; TRIM24
Function nuclear hormone receptor binding
Related Protein CTNNB1; NCOR1; MED1; SIRT1; NCOA2; MYOD1; HIF1A; TCF7L2; Ankar; NCOA3
Function protein binding
Related Protein Kitl; SRGAP2; MTNR1B; NAPG; C19orf25; CCNK; ITGB3; ARHGAP26; L3MBTL1; PCGF3
Function retinoid X receptor binding
Related Protein NR4A2; NR0B2; HMGA1; MED25; NRIP1; NCOR1; FUS; RARG; NR1H2; VDR
Function sequence-specific DNA binding
Related Protein NFYBA; GTF2E1; HOXB7; HOXA10B; ETV5B; UNCX; SP1; RERE; HOXA11A; USF1
Function thyroid hormone receptor binding
Related Protein MED12; GAS2L1; NUP62; PRMT2; FUS; THRAP3; MED16; MED1; MED17; NCOR1
Function transcription corepressor activity
Related Protein DDX54; SUFU; ZHX3; CCND1; NR0B1; ZEB1; E2F7; HOXC6; SFMBT1; CCAR1
Function transcription factor activity, sequence-specific DNA binding
Related Protein NFYA; TFCP2L1; HIC1; GCM1; ZNF711; DMRT3A; NFAT5; IKZF3; HOXC4; TFDP1A
Function transcription regulatory region DNA binding
Related Protein TBX21; TRP53; RELA; FOXA3; REST; CDK5RAP2; TRP63; MTERFD3; PPARG; SALL4

Interacting Protein

NCOR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOR1.
HDAC3; RARA; SKI; TRIM28; SMARCA4; SMARCB1; DHX30