Active Recombinant Human NCOR1, His-tagged
Cat.No. : | NCOR1-8484H |
Product Overview : | Recombinant Human NCOR1, fused with His tag, was expressed in Sf21 Cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. |
Source : | Sf21 Cells |
Species : | Human |
Tag : | His |
Form : | 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA |
Bio-activity : | 1 unit equals 1 ng of purified protein. 100 units are sufficient for a protein-protein interaction assay. |
Purity : | >95% as determined by SDS-PAGE |
Storage : | -80 °C |
Concentration : | 700 μg/ml |
Shipping : | Dry Ice |
Gene Name : | NCOR1 nuclear receptor corepressor 1 [ Homo sapiens ] |
Official Symbol : | NCOR1 |
Synonyms : | NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1; nuclear receptor co-repressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1; N-CoR; N-CoR1; hN-CoR; |
Gene ID : | 9611 |
mRNA Refseq : | NM_006311 |
Protein Refseq : | NP_006302 |
MIM : | 600849 |
UniProt ID : | O75376 |
Chromosome Location : | 17p11.2 |
Pathway : | Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; |
Function : | histone deacetylase binding; histone deacetylase regulator activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thyroid hormone receptor binding; transcription corepressor activity; transcription corepressor activity; transcription regulatory region DNA binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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