Active Recombinant Human NCOR1, His-tagged
Cat.No. : | NCOR1-8484H |
Product Overview : | Recombinant Human NCOR1, fused with His tag, was expressed in Sf21 Cells. |
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Description : | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. |
Source : | Sf21 Cells |
Species : | Human |
Tag : | His |
Form : | 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA |
Bio-activity : | 1 unit equals 1 ng of purified protein. 100 units are sufficient for a protein-protein interaction assay. |
Purity : | >95% as determined by SDS-PAGE |
Storage : | -80 °C |
Concentration : | 700 μg/ml |
Shipping : | Dry Ice |
Gene Name : | NCOR1 nuclear receptor corepressor 1 [ Homo sapiens ] |
Official Symbol : | NCOR1 |
Synonyms : | NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1; nuclear receptor co-repressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1; N-CoR; N-CoR1; hN-CoR; |
Gene ID : | 9611 |
mRNA Refseq : | NM_006311 |
Protein Refseq : | NP_006302 |
MIM : | 600849 |
UniProt ID : | O75376 |
Chromosome Location : | 17p11.2 |
Pathway : | Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem; |
Function : | histone deacetylase binding; histone deacetylase regulator activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thyroid hormone receptor binding; transcription corepressor activity; transcription corepressor activity; transcription regulatory region DNA binding; |
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