ndufs7
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
  • Background
  • This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain.;This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone;oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone;is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to;mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic;lesions in subcortical brain regions.
  • Synonyms
  • NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 7 (20kD) (NADH coenzyme Q reductase); CI 20; complex I 20kDa subunit; FLJ45860; FLJ46880; NADH dehydrogenase [ubiquinon
Cat.#:NDUFS7-562HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NDUFS7
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Cat.#:NDUFS7-10547MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDUFS7 Protein
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Cat.#:NDUFS7-7890ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFS7
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Cat.#:NDUFS7-3893HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS7 293 Cell Lysate
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Involved Pathway

NDUFS7 involved in several pathways and played different roles in them. We selected most pathways NDUFS7 participated on our site, such as Alzheimers disease, Electron Transport Chain, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
CALML3; NDUFV3; APAF1; ATP2A1; CAPN1; COX8A; UQCRC2; NDUFS5; NDUFB10; PPP3CB
Electron Transport Chain
COX6A2; COX8A; SLC25A27; ATP5L; NDUFS7; SURF1; NDUFC2-KCTD14; COX7A2; COX4I1; COX6A1
Huntingtons disease
NDUFC1; POLR2I; NDUFA9; NDUFA1; DNAH11; PPARGC1A; HAP1; Atp5g2; NDUFA12; NDUFS4
Metabolic pathways
ALDH1B1; NDUFS6; MBOAT2B; MAT2A; PKMB; EPT1; ATP6AP1B; CKMT1B; MVK; PON2
Metabolism
SLC5A2; COX16; CYP27B1; D2HGDH; LSM1; COQ7; FA2H; TPTE; FAAH2; CYP24A1
Non-alcoholic fatty liver disease (NAFLD)
MAPK9; NDUFA12; NDUFA4L2; COX7A2; PIK3CG; ADIPOR1; NDUFB1; NDUFS3; LEPR; PIK3CB
Oxidative phosphorylation
ATP5J2; NDUFB3; UQCR10; COX17; NDUFA10; ATP5C1; SDHB; ATP6V0A2; ATP6V0A1B; ATP5H
Parkinsons disease
GNAI3; PPIF; COX6A2; GNAI2; NDUFA4L2; ATP5G3; UBA1; SLC25A5; Casp3; ATP5A1

Protein Function

NDUFS7 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, contributes_to NADH dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS7 itself. We selected most functions NDUFS7 had, and list some proteins which have the same functions with NDUFS7. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein SDHB; CDKAL1; NDUFS8; RSAD2; EXO5; NDUFS8A; POLA1; NTHL1; PPAT; MOCS1
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFS5; NDUFC1; NDUFC2-KCTD14; NDUFA8; NDUFS6; NDUFA1; NDUFB2; NDUFS4; NDUFA13; NDUFA3
Function contributes_to NADH dehydrogenase activity
Related Protein NDUFS7; NDUFV1; NDUFS2; NDUFS8
Function metal ion binding
Related Protein TP63; PDLIM5B; COX5A; ZNF584; ZNF547; RFESD; TPH1B; SGSH; HEPHL1A; CLCA4
Function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Related Protein AKR1C6; NDUFS7; AKR1C21; AKR1C4; AKR1C3; DHRS4; DCXR; AKR1C2; CBR1
Function protease binding
Related Protein BCL10; LRP1; CST3; CHL1; INS2; TRIP4; Serpina1b; FN1; ITGB1; RNF139
Function protein binding
Related Protein RALY; MED28; SOX14; EPHA10; BFSP1; CBX1; LGALS8; CLEC16A; RFWD2; GTF2H4
Function quinone binding
Related Protein HHIPL1; VKORC1; AMOTL1; ABP1; NDUFS2; HHIPL2; NDUFS7; AOC2; AOC3; VKORC1L1

Interacting Protein

NDUFS7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS7 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS7.
NDUFA2; ENO2; ARRB2; NDUFS8; NDUFS5; NDUFS2; NDUFS3; SCO1; ETHE1; NQO1; NDUFS1; LONP1; NDUFA6; ALDH6A1; NDUFA5; NDUFA9; NDUFAF5