ndufs7
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
  • Background
  • This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain.;This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone;oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone;is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to;mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic;lesions in subcortical brain regions.
  • Synonyms
  • NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 7 (20kD) (NADH coenzyme Q reductase); CI 20; complex I 20kDa subunit; FLJ45860; FLJ46880; NADH dehydrogenase [ubiquinon
Cat.#:NDUFS7-562HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NDUFS7
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Cat.#:NDUFS7-10547MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDUFS7 Protein
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Cat.#:NDUFS7-7890ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFS7
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Cat.#:NDUFS7-3893HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS7 293 Cell Lysate
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Involved Pathway

NDUFS7 involved in several pathways and played different roles in them. We selected most pathways NDUFS7 participated on our site, such as Alzheimers disease, Electron Transport Chain, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
NDUFA6; IDE; CALML5; CALML3; ATP5D; CASP8; COX7A2L; NDUFS8; PPP3R2; NDUFS4
Electron Transport Chain
NDUFC2-KCTD14; COX6A1; SCO1; SURF1; COX6A2; COX15; ATPIF1; COX4I1; COX6B1; SLC25A27
Huntingtons disease
DCTN4; GNAQ; POLR2E; BDNF; UCP1; NDUFB6; SLC25A6; DNAL4; SIN3A; NDUFA11
Metabolic pathways
UGT1AB; BCO1; PTGDSB; EXT1; ACSL4; PTGS2A; ADSSL1; HSD17B8; NDUFA9; GPIB
Metabolism
LMF1; PFKLB; LMF2; CDO1; CIAO1; NUDT3A; SLC5A2; AFMID; SLC25A14; CHKA
Non-alcoholic fatty liver disease (NAFLD)
LEP; NDUFA3; DDIT3; Il6ra; SDHB; NDUFC2; CEBPA; FASLG; IRS1; TNF
Oxidative phosphorylation
COX4I2; NDUFS8; ATP5J2; ATP5G3A; ATP6V1G3; ATP5D; COX7A2L; NDUFB3; ATP6V1E2; ATP6V0B
Parkinsons disease
NDUFS6; UQCRC1; ATP5A1; COX6B2; UBA7; NDUFB10; NDUFC1; NDUFS8; SLC18A2; COX7A2L

Protein Function

NDUFS7 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, NADH dehydrogenase (ubiquinone) activity, contributes_to NADH dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS7 itself. We selected most functions NDUFS7 had, and list some proteins which have the same functions with NDUFS7. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein MOCS1; ACO2; PPAT; ISCA2; DDX11; DEM1; DPYD; ISCU; ISCA1; NUBP1
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFA12; NDUFS7; NDUFA7; NDUFA13; NDUFC2-KCTD14; NDUFA2; NDUFAF2; NDUFS5; NDUFB4; NDUFA5
Function contributes_to NADH dehydrogenase activity
Related Protein NDUFS8; NDUFS2; NDUFS7; NDUFV1
Function metal ion binding
Related Protein ZFP280D; ZSCAN4C; ZNF839; FYNB; GNS; FAHD2A; CHORDC1; CYP4A12A; ZNF436; AMPD1
Function oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Related Protein CBR1; DHRS4; DCXR; AKR1C3; AKR1C21; AKR1C2; AKR1C6; AKR1C4; NDUFS7
Function protease binding
Related Protein RNF139; INS; DERL1; BCL10; Serpina1c; TRIP4; PINK1; F3; LDLR; XBP1
Function protein binding
Related Protein OFD1; OIP5; AGAP2; SIRT4; CNTNAP1; WAS; ACTR6; MAGEA11; DR1; RECK
Function quinone binding
Related Protein ABP1; VKORC1; AOC1; HHIP; CBR4; NDUFS2; NDUFS7; ETFDH; AOC2; SQRDL

Interacting Protein

NDUFS7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS7 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS7.
NDUFA2; ENO2; ARRB2; NDUFS8; NDUFS5; NDUFS2; NDUFS3; SCO1; ETHE1; NQO1; NDUFS1; LONP1; NDUFA6; ALDH6A1; NDUFA5; NDUFA9; NDUFAF5