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NDUFS8

  • Official Full Name

    NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)

  • Overview

    This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.
  • Synonyms

    NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 8 (23kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; CI 23k; complex I 23kDa subunit; NADH dehydrogenase [ubiquinone] iron sulfur protein 8; mitochondrial; TYKY; BC021616; CI23KD; MGC101957; MGC37950; MS109; NADH dehydrogenase (ubiquinone) Fe S protein 8, 23kDa (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 23 kDa subunit; TYKY subunit; complex I-23kD; NADH-ubiquinone oxidoreductase 23 kDa subunit; CI-23k;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NDUFS8-3892HCL Recombinant Human NDUFS8 293 Cell Lysate HEK293 N/A
Rhesus Macaque NDUFS8-2991R Recombinant Rhesus monkey NDUFS8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NDUFS8-2810R Recombinant Rhesus Macaque NDUFS8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NDUFS8-2810R-B Recombinant Rhesus Macaque NDUFS8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NDUFS8 Related Articles

NDUFS8 involved in several pathways and played different roles in them. We selected most pathways NDUFS8 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationCOX6B2;SDHDB;NDUFS1;ATP6V0D2;UQCR10;NDUFB3;NDUFB7;ATP6V0D1;ATP6V1AA
Metabolic pathwaysPIGB;COX4I2;SI;CYP2C50;PAPSS1;AK9;POLD1;HK2;MTMR1A
Non-alcoholic fatty liver disease (NAFLD)CEBPA;IRS1;CASP8;NDUFB3;PIK3R1;NDUFA12;FAS;COX7A1;RAC1
Alzheimers diseaseNDUFV3;BACE1;TNFRSF1A;ATP5C1;NDUFA2;PSENEN;NDUFA13;CALM2;ATP5H
Parkinsons diseaseNDUFS7;PRKACB;PRKACG;UQCRQ;GNAI3;UQCRH;mt-Atp8;LRRK2;SLC25A6
Huntingtons diseaseATP5C1;COX6B1;DNAH5;COX5B;NDUFA8;CYCS;GRIN2B;ATP5F1;ITPR1

NDUFS8 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, contributes_to NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS8 itself. We selected most functions NDUFS8 had, and list some proteins which have the same functions with NDUFS8. You can find most of the proteins on our site.

Function Related Protein
4 iron, 4 sulfur cluster bindingACO2;NDUFV1;ACO1;NDUFS8B;PRIM2;ISCA1;EXO5;TYW1;ERCC2
contributes_to NADH dehydrogenase (ubiquinone) activityNDUFS4;NDUFS1;NDUFS8
NADH dehydrogenase (ubiquinone) activityNDUFB1;NDUFV1;NDUFC1;NDUFB9;NDUFB7;NDUFB5;NDUFS3;NDUFB10;NDUFB2
contributes_to NADH dehydrogenase activityNDUFV1;NDUFS8;NDUFS7;NDUFS2
metal ion bindingPRR3;TRIM35-20;ZNF7;FAM170A;POLK;PPM1G;RASAL1;ILKAP;KEL

NDUFS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS8.

vpr; NDUFA2; MLH1; GEM; NDUFS4; NDUFS5; NDUFS7; NDUFS6; NDUFS3; NDUFV1; NDUFA6; ICT1; NDUFA9; NDUFA11; NDUFAF3; TIMMDC1; NDUFA12

Triepels, RH; Hanson, BJ; et al. Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns. JOURNAL OF BIOLOGICAL CHEMISTRY 276:8892-8897(2001).
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