ndufs8
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
  • Background
  • This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.
  • Synonyms
  • NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 8 (23kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; CI 23k; complex I 23kDa subunit; NADH dehydrogenase [ubiquinone] iron sulfur protein 8; mitochondrial; TYKY; BC021616; CI23KD; MGC101957; MGC37950; MS109; NADH dehydrogenase (ubiquinone) Fe S protein 8, 23kDa (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 23 kDa subunit; TYKY subunit; complex I-23kD; NADH-ubiquinone oxidoreductase 23 kDa subunit; CI-23k
Cat.#:NDUFS8-2991RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NDUFS8 Protein, His-tagged
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Cat.#:NDUFS8-3892HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS8 293 Cell Lysate
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Involved Pathway

NDUFS8 involved in several pathways and played different roles in them. We selected most pathways NDUFS8 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
NDUFA6; ATP6AP1B; UQCRB; COX4I2; ATP6V0E2; ATP6V1C1; UQCRC2; NDUFB3; NDUFS8B; COX7A2L
Metabolic pathways
GALNT14; INPP4AB; NDUFS4; ADSSL1; BCAT2; PYGM; PLA2G10; ACSL3A; GLUD2; DHRS13L1
Non-alcoholic fatty liver disease (NAFLD)
TGFB1; IL6R; PIK3CB; ITCH; COX5A; NDUFB7; RAC1; Fasl; PIK3CD; UQCRC2
Alzheimers disease
PPP3CB; TNF; NDUFV1; UQCRH; NDUFB4; EIF2AK3; NDUFS4; NDUFS3; APH1C; COX7B2
Parkinsons disease
NDUFS7; ATP5B; NDUFB1; SLC25A5; UBE2L3; NDUFAB1; SNCA; NDUFA4; GNAL; NDUFB8
Huntingtons disease
POLR2A; ATP5A1; SDHA; NDUFA9; APAF1; ITPR1; TBPL2; NDUFB6; NDUFA6; UCP1

Protein Function

NDUFS8 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, contributes_to NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS8 itself. We selected most functions NDUFS8 had, and list some proteins which have the same functions with NDUFS8. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein MUTYH; TYW1; ISCA1; NUBPL; RSAD2; PPAT; NUBP2; NUBP1; TYW1B; DDX11
Function contributes_to NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFS4; NDUFS1; NDUFS8
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFB3; NDUFB6; NDUFS6; NDUFAB1; NDUFC2-KCTD14; NDUFV2; NDUFB7; NDUFC1; NDUFB9; NDUFS3
Function contributes_to NADH dehydrogenase activity
Related Protein NDUFS2; NDUFS8; NDUFS7; NDUFV1
Function metal ion binding
Related Protein S100T; PDE4C; ADPRM; CYP2AA12; PHOSPHO2; ANG3; TESK1; ADH1; SLC25A25A; C1GALT1A

Interacting Protein

NDUFS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS8.
vpr; NDUFA2; MLH1; GEM; NDUFS4; NDUFS5; NDUFS7; NDUFS6; NDUFS3; NDUFV1; NDUFA6; ICT1; NDUFA9; NDUFA11; NDUFAF3; TIMMDC1; NDUFA12

NDUFS8 Related Articles

Triepels, RH; Hanson, BJ; et al. Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns. JOURNAL OF BIOLOGICAL CHEMISTRY 276:8892-8897(2001).