ndufs8
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
  • Background
  • This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.
  • Synonyms
  • NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 8 (23kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; CI 23k; complex I 23kDa subunit; NADH dehydrogenase [ubiquinone] iron sulfur protein 8; mitochondrial; TYKY; BC021616; CI23KD; MGC101957; MGC37950; MS109; NADH dehydrogenase (ubiquinone) Fe S protein 8, 23kDa (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 23 kDa subunit; TYKY subunit; complex I-23kD; NADH-ubiquinone oxidoreductase 23 kDa subunit; CI-23k
Cat.#:NDUFS8-2991RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NDUFS8 Protein, His-tagged
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Cat.#:NDUFS8-3892HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS8 293 Cell Lysate
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Involved Pathway

NDUFS8 involved in several pathways and played different roles in them. We selected most pathways NDUFS8 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
NDUFA1; ATP6V1C2; ATP6V0A2B; UQCRFS1; mt-Atp8; ATP5G3A; NDUFA3; ATP6V1B1; NDUFS8B; COX8C
Metabolic pathways
LIPG; MTMR1B; NDUFS1; PPCDC; C1GALT1C1; RPN2; POLR2EB; CYP1A; LSM1; POLA2
Non-alcoholic fatty liver disease (NAFLD)
GSK3A; NDUFB1; PRKAG3; NDUFB2; MAP3K5; NDUFV3; PRKAB1; PIK3R2; Casp3; COX7A2L
Alzheimers disease
APBB1; ITPR1; NDUFB4; BACE1; NDUFA8; PSEN2; APOE; CALM4; CYCS; GRIN1
Parkinsons disease
NDUFA3; UBE2J1; NDUFS6; NDUFAB1; DRD1A; ATP5G1; NDUFV1; VDAC3; ATP5J; NDUFA13
Huntingtons disease
Atp5g2; COX7C; VDAC2; ATP5F1; NDUFB7; NDUFS7; NDUFC1; BBC3; HIP1; COX6C

Protein Function

NDUFS8 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, contributes_to NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS8 itself. We selected most functions NDUFS8 had, and list some proteins which have the same functions with NDUFS8. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein REV3L; NDUFS8B; LIAS; POLA1; NUBP2; IREB2; DDX11; NDUFS8; CDKAL1; RSAD1
Function contributes_to NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFS8; NDUFS1; NDUFS4
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFC2; NDUFB9; NDUFA12; NDUFB2; NDUFB10; NDUFV3; NDUFS3; NDUFA10; NDUFB5; NDUFS8
Function contributes_to NADH dehydrogenase activity
Related Protein NDUFS2; NDUFS8; NDUFV1; NDUFS7
Function metal ion binding
Related Protein COL27A1B; OAS2; TGM4; PKM; ZNF238; ZNF292B; ZIC6; ZFP36L2; ZNHIT6; ZNF658

Interacting Protein

NDUFS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS8.
vpr; NDUFA2; MLH1; GEM; NDUFS4; NDUFS5; NDUFS7; NDUFS6; NDUFS3; NDUFV1; NDUFA6; ICT1; NDUFA9; NDUFA11; NDUFAF3; TIMMDC1; NDUFA12

NDUFS8 Related Articles

Triepels, RH; Hanson, BJ; et al. Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns. JOURNAL OF BIOLOGICAL CHEMISTRY 276:8892-8897(2001).