ndufv1
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
  • Background
  • The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinsons disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Synonyms
  • NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa; NADH dehydrogenase (ubiquinone) flavoprotein 1 (51kD); NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; CI 51K; complex I 51kDa subunit; NADH dehydrogenase [ubiquinone] flavoprotein 1; mitochondrial; CI 51kD; CI-51kD; Complex I 51kD; Complex I-51kD; FLJ59059; NADH dehydrogenase (ubiquinone) flavoprotein 1; NADH dehydrogenase flavoprotein 1; NADH ubiquinone oxidoreductase 51 kDa subunit; NADH ubiquinone oxidoreductase; NADH-ubiquinone oxidoreductase 51 kDa subunit; NDUFV 1; NDUV1_HUMAN; UQOR1; OTTHUMP00000232178; OTTHUMP00000232181; OTTHUMP00000232183; OTTHUMP00000232187; complex I 51 kda subunit; complex I, mitochondrial respiratory chain; NADH-ubiquinone oxidoredu; CI-51K; CI51KD
Cat.#:NDUFV1-1243HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFV1, GST-tagged
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Cat.#:NDUFV1-29479THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NDUFV1
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Cat.#:NDUFV1-10548MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDUFV1 Protein
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Cat.#:NDUFV1-741CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NDUFV1 Protein, His-tagged
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Cat.#:NDUFV1-3224CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NDUFV1
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Cat.#:NDUFV1-1086ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFV1
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Cat.#:NDUFV1-1180HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFV1 cell lysate
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Involved Pathway

NDUFV1 involved in several pathways and played different roles in them. We selected most pathways NDUFV1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFV1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
NDUFB7; NDUFA11; ATP6V0A2; NDUFB9; COX6A2; ATP5G3B; COX6B2; PPA1; SDHDB; MT-ATP6
Metabolic pathways
mt-Atp8; MECR; OGDHL; ACADM; PDXKA; EXT1C; FPGS; UGT1A6B; AANAT2; AMT
Non-alcoholic fatty liver disease (NAFLD)
CEBPA; NDUFB5; IL-8; DDIT3; NDUFV1; NDUFA2; MAPK8; INS; PIK3CB; Casp3
Alzheimers disease
CDK5R1; SDHA; ATP5J; COX6A1; COX7A2; ATP2A1; NDUFA6; COX6C; PLCB2; ATP5E
Parkinsons disease
NDUFB8; NDUFS8; VDAC3; ATP5G1; Atp5g2; SNCA; MT-ND4; NDUFS4; NDUFA1; UBE2J1
Huntingtons disease
PLCB2; SDHC; POLR2A; PLCB3; UQCRH; NDUFA3; POLR2I; CREB5; COX7A2; POLR2C

Protein Function

NDUFV1 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, contributes_to FMN binding, NAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFV1 itself. We selected most functions NDUFV1 had, and list some proteins which have the same functions with NDUFV1. You can find most of the proteins on our site.
Function
Related Protein
Function 4 iron, 4 sulfur cluster binding
Related Protein BRIP1; ISCA2; PRIM2; NDUFV1; ACO1; DEM1; NDUFS1; RSAD1; POLD1; ETFDH
Function contributes_to FMN binding
Related Protein NDUFV1
Function NAD binding
Related Protein HPGD; GAPDHS; HIBADH; NNT; NDUFV1; BDH2; MDH1; PARP1; GPD1B; NDUFS2
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFS5; NDUFB6; NDUFC2-KCTD14; NDUFA7; NDUFAF2; NDUFC1; NDUFV3; NDUFA5; NDUFA8; NDUFV2
Function contributes_to NADH dehydrogenase activity
Related Protein NDUFS8; NDUFV1; NDUFS2; NDUFS7
Function metal ion binding
Related Protein ZFP787; CENPT; ZFP64; UPB1; PRKCBP1L; PLA2G4AA; ZNF222; LMO7B; YOD1; HELZ2

Interacting Protein

NDUFV1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFV1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFV1.
NDUFA2; EWSR1; NDUFS8; NDUFS4; NDUFS5; NDUFS2; NDUFS6; NDUFS3; NDUFB4; MT-ND1; MT-ND5; NDUFV2; NDUFS1; HTT; OXCT1; NDUFV3