neil3
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  • Official Full Name
  • nei endonuclease VIII-like 3 (E. coli)
  • Background
  • NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate;the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA;strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed 12509226)).
  • Synonyms
  • NEIL3; nei endonuclease VIII-like 3 (E. coli); endonuclease 8-like 3; FLJ10858; FPG2; hFPG2; hNEI3; 123; AI449477; BC034753; C85903; DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; EC 3.2.2.-; EC 4.2.99.18; Endonuclease VIII-like 3; FGP2; MGC27861; MGC36916; nei endonuclease VIII-like 3; Nei like 3 (E. coli); Nei-like protein 3; NEIL3_HUMAN; OTTHUMP00000218810; RGD1310562; NEI3
Cat.#:NEIL3-912HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NEIL3
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Cat.#:NEIL3-10568MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NEIL3 Protein
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Cat.#:Neil3-1446MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Neil3 protein, His & T7-tagged
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Cat.#:NEIL3-1724ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NEIL3
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Cat.#:NEIL3-3880HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NEIL3 293 Cell Lysate
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Involved Pathway

NEIL3 involved in several pathways and played different roles in them. We selected most pathways NEIL3 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEIL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base excision repair
PCNA; POLD4; LIG1; LIG3; PARP1; POLE2; MPG; POLD1; OGG1; NEIL3

Protein Function

NEIL3 has several biochemical functions, for example, DNA N-glycosylase activity, DNA-(apurinic or apyrimidinic site) lyase activity, bubble DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEIL3 itself. We selected most functions NEIL3 had, and list some proteins which have the same functions with NEIL3. You can find most of the proteins on our site.
Function
Related Protein
Function DNA N-glycosylase activity
Related Protein OGG1; SMUG1; NEIL1; NEIL3; TDG; NTHL1
Function DNA-(apurinic or apyrimidinic site) lyase activity
Related Protein RPS3; HMGA1B; APLF; HMGA1-RS1; APEX1; NEIL3; ALKBH1; HMGA1A; NEIL2; NTHL1
Function bubble DNA binding
Related Protein BLM; WRN; ERCC5; NEIL3; HMGB1; RECQL4
Function damaged DNA binding
Related Protein POLB; MPG; RPS3; XPC; PNKP; NEIL3; POLI; RAD52; DCLRE1C; MGMT
Function double-stranded DNA binding
Related Protein AKAP8; GTF2H4; HES2; HMGB1; FEN1; RAD51B; HNRNPDL; YBX1; SP8B; GATA1A
Function single-stranded DNA binding
Related Protein ERCC5; RPA3; ANXA1; RAD51B; NCL; WBP11; RAD51D; OBFC2B; IGHMBP2; PURB
Function zinc ion binding
Related Protein USP5; EWSR1; RNF215; MSRB1; TAB2; RCHY1; RNPEP; BAZ2A; UPF1; HDAC4

Interacting Protein

NEIL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEIL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEIL3.
TP53; TWIST1; SF3B2; PRPF40A; SLC2A1; RBM25; SMARCA4; Ect2; SFSWAP; NNT; ROCK1; GPATCH4; RSBN1L; BCL7C; HMCES; ENY2; CDKN2AIP; GLTSCR1; SLC25A13