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NEK2

  • Official Full Name

    NIMA (never in mitosis gene a)-related kinase 2

  • Overview

    NEK2 is a serine/threonine kinase involved in mitotic regulation. NEK2 also known as serine/threonine protein kinase Nek2, NimA-related protein kinase 2, and HSPK21, can be expressed as 3 different isoforms as a result of alternative splicing.. The predic
  • Synonyms

    NEK2; NIMA (never in mitosis gene a)-related kinase 2; serine/threonine-protein kinase Nek2; HsPK 21; NEK2A; NLK1; nimA-like protein kinase 1; nimA-related protein kinase 2; HsPK21;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect (sf21)
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • No tag
  • Tag
  • free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEK2-549H Active Recombinant Human NEK2, GST-tagged Sf9 Insect Cell GST
Human NEK2-368H Recombinant Human NEK2, GST-tagged, Active Sf9 Insect Cell GST
Human NEK2-663H Recombinant Human NEK2, Active E.coli N/A
Human NEK2-558H Recombinant Human NEK2, His-tagged Sf9 Insect Cell His
Human NEK2-1258H Recombinant Human NEK2, GST-tagged E.coli GST 1-362aa
Human NEK2-29279TH Recombinant Human NEK2 N/A
Human NEK2-1183HCL Recombinant Human NEK2 cell lysate N/A
Human NEK2-788H Recombinant Human NEK2 Protein, His-tagged E.coli His Lys125~Asn393
Human NEK2-2744HF Active Recombinant Full Length Human NEK2 Protein Insect (sf21) Tag-free 1-445
Human NEK219910H Recombinant Human NEK2 (8-271) (T175A) Protein
Human NEK2-0905H Recombinant Human NEK2 Protein (1-271, T175A), Tag Free E.coli No tag 1-271, T175A
Human NEK227377H Recombinant Human NEK2 (1-271) (T175A) Protein
Human NEK2-0906H Recombinant Human NEK2 Protein (1-271, T175A), His tagged E.coli His 1-271, T175A
Human NEK2-4681H Recombinant Human NEK2 Protein (Lys125-Leu212), N-His tagged E.coli N-His Lys125-Leu212
Mouse NEK2-10572M Recombinant Mouse NEK2 Protein Mammalian Cell His
Mouse Nek2-789M Recombinant Mouse Nek2 Protein, His-tagged E.coli His Phe148~Glu397
Mouse NEK2-6009M Recombinant Mouse NEK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NEK2-6009M-B Recombinant Mouse NEK2 Protein Pre-coupled Magnetic Beads HEK293
Rat Nek2-790R Recombinant Rat Nek2 Protein, His-tagged E.coli His Val137~Glu400
Rhesus Macaque NEK2-2998R Recombinant Rhesus monkey NEK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NEK2-2817R-B Recombinant Rhesus Macaque NEK2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NEK2-2817R Recombinant Rhesus Macaque NEK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish NEK2-11278Z Recombinant Zebrafish NEK2 Mammalian Cell His
Chicken NEK2-2730C Recombinant Chicken NEK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NEK2 Related Articles
  • NEK2 Related Research Area

NEK2 involved in several pathways and played different roles in them. We selected most pathways NEK2 participated on our site, such as APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
APC-Cdc20 mediated degradation of Nek2AUBE2C;ANAPC10;NEK2
APC/C-mediated degradation of cell cycle proteinsPSMD10;ANAPC10;NEK2;PSMA8;PSMD14;PSMD5;UBE2C;PSME3;PSMD9
APC/C:Cdc20 mediated degradation of mitotic proteinsPSMD10;PSMD14;PSME3;PSMD5;ANAPC10;NEK2;PSMA8;PSMD9;UBE2C
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointPSMA8;PSME3;PSMD14;NEK2;PSMD10;ANAPC10;PSMD5;UBE2C;PSMD9
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsUBE2C;NEK2;PSME3;PSMD5;PSMD9;PSMD10;ANAPC10;PSMA8;PSMD14
Anchoring of the basal body to the plasma membraneTUBB4A;SDCCAG8;CSNK1D;CETN2;B9D1;CEP89;TUBG1;DCTN3;CEP164
Assembly of the primary ciliumKIF3B;DYNC1H1;CCP110;BBS7;DYNLRB2;TNPO1;MAPRE1A;CEP57;PCM1
Cell CycleCDH1-A;CTDNEP1;MASTL;CTDNEP1A;MCM8;CCNE2;CLASP1;CENPH;ORC4L

NEK2 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK2 itself. We selected most functions NEK2 had, and list some proteins which have the same functions with NEK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACLYA;NLRP9C;IGF1R;PDK3;DDX23;UBE2G2;PIP5K1C;TK2;MYO1C
metal ion bindingZNF672;ZNF582;CDKN1A;LACTB2;TSHZ1;SPATA21;ZNF750;ZFP91;ZNF219
protein bindingPYGO1;ASNS;EEF1G;NDP;PRDX6;PDK3;TTC19;PDE1B;UBL4A
protein kinase activityKSR1;BMPR1AB;CSNK1G2A;VSIG8B;KITB;GUCY2F;CASKA;PDPK1A;AURKC
protein phosphatase bindingANAPC7;SNX3;PPP6R1;ANAPC5;RPA3;KCNN4;ANAPC4;DRD1A;SHOC2
protein serine/threonine kinase activityMTOR;ATM;PDK3;PSKH2;SRPK3;MAP3K2;CAMK2G1;ILK;PAK1

NEK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK2.

NEK11; Cdc23; Cdc16; Cdc26; CDC16; cdc27; CDC27

Mbom, BC; Siemers, KA; et al. Nek2 phosphorylates and stabilizes beta-catenin at mitotic centrosomes downstream of Plk1. MOLECULAR BIOLOGY OF THE CELL 25:977-991(2014).
Kim, S; Hwang, SK; et al. Fanconi anemia complementation group A (FANCA) localizes to centrosomes and functions in the maintenance of centrosome integrity. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 45:1953-1961(2013).
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