nhlrc1
Share
  • Official Full Name
  • NHL repeat containing 1
  • Background
  • The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded;protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as;progressive myoclonic epilepsy type 2 (EPM2).
  • Synonyms
  • NHLRC1; NHL repeat containing 1; E3 ubiquitin-protein ligase NHLRC1; bA204B7.2; epilepsy; progressive myoclonus type 2B; EPM2B; malin; MGC119265; EPM2A; MGC119262; MGC119264; NHL repeat containing protein 1; NHL repeat-containing protein 1; NHLC1_HUMAN; NHLRC 1
Cat.#:NHLRC1-1291HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NHLRC1, GST-tagged
+Inquiry
Cat.#:NHLRC1-3984RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NHLRC1 Protein
+Inquiry

Involved Pathway

NHLRC1 involved in several pathways and played different roles in them. We selected most pathways NHLRC1 participated on our site, such as Glucose metabolism, Glycogen synthesis, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NHLRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glucose metabolism
PYGMB; SLC25A12; EPM2A; NHLRC1; SLC25A1A; AGL; SLC25A10; GYG1A; SLC25A11; GYG1B
Glycogen synthesis
GYG1B; NHLRC1; EPM2A; GYG1A
Metabolism
SPTLC1; CYP2K6; SLC35D1A; MED26; NUBP2; ELA2; CYP2C18; CYP4T8; NOSIP; ACOT6
Metabolism of carbohydrates
B3GNT1; SLC35B2; PFKLB; SLC35D2; HS3ST6; UST; OMD; NHLRC1; TREH; SLC5A9
Ubiquitin mediated proteolysis
ANAPC13; FLJ11011L; HERC2; UBA7; UBE2G1A; BIRC3; TCEB1B; ANAPC4; SKP1; FBXW11B

Protein Function

NHLRC1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NHLRC1 itself. We selected most functions NHLRC1 had, and list some proteins which have the same functions with NHLRC1. You can find most of the proteins on our site.
Function
Related Protein
Function ligase activity
Related Protein PIAS1; MUL1; ACSF2; ATG3; EGR2; TRIM17; NEURL1B; TRIM58; UBE2IA; RNF19B
Function protein binding
Related Protein NR2F6; TMEM194; ZBTB25; KEL; MOCS3; DERL1; HAAO; SNCA; HPS1; SZL
Function ubiquitin protein ligase activity
Related Protein UBE2J1; PARK2; RNF144B; RNF7; UBE3B; TRIM11; UBE2J2; TRIM2; RNF19B; CDC34A
Function ubiquitin-protein transferase activity
Related Protein RC3H2; BIRC5; UBE2S; BARD1; TRIM37; RNF115; ANAPC4; FLJ11011L; PRP19; RNF6
Function zinc ion binding
Related Protein ADA; TET1; ADAMTS3; RNF24; RNF126; TRAF5; LIMS2; Adam6; TCEA3; RNF185

Interacting Protein

NHLRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NHLRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NHLRC1.
EPM2A; Epm2a; HSP90AB1

NHLRC1 Related Articles

Smith, JA; Lovley, DR; et al. Outer Cell Surface Components Essential for Fe(III) Oxide Reduction by Geobacter metallireducens. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 79:901-907(2013).
Brackmann, FA; Kiefer, A; et al. Rapidly Progressive Phenotype of Lafora Disease Associated With a Novel NHLRC1 Mutation. PEDIATRIC NEUROLOGY 44:475-477(2011).