NIPBL
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Official Full Name
NIPBL Nipped-B homolog (Drosophila)
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Overview
Background:The 26 S proteasome is a protein complex with a molecular mass of 2000 kDa. It is essential not only for eliminating damaged or misfolded proteins but also for degrading short lived regulatory proteins involved in cell cycle regulation DNA repair signal transduction apoptosis and metabolic regulation.Rpn3p is essential non-ATPase regulatory subunit of the 26S proteasome lid similar to the p58 subunit of the human 26S proteasome. -
Synonyms
NIPBL; Nipped-B homolog (Drosophila); nipped-B-like protein; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; IDN3; Scc2; sister chromatid cohesion 2 homolog (yeast); delangin; SCC2 homolog; sister chromatid cohesion 2 homolog; CDLS; CDLS1; IDN3-B; FLJ44854;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | NIPBL-1296H | Recombinant Human NIPBL, GST-tagged | E.coli | GST | 2523-2686aa | |
| Human | NIPBL-6635HF | Recombinant Full Length Human NIPBL Protein, GST-tagged | In Vitro Cell Free System | GST | 175 amino acids |
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| Human | NIPBL-5872H | Recombinant Human NIPBL Protein, GST-tagged | Wheat Germ | GST |
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| Mouse | NIPBL-10676M | Recombinant Mouse NIPBL Protein | Mammalian Cell | His |
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| Mouse | NIPBL-6073M | Recombinant Mouse NIPBL Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | NIPBL-6073M-B | Recombinant Mouse NIPBL Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
NIPBL involved in several pathways and played different roles in them. We selected most pathways NIPBL participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cohesin Loading onto Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with NIPBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell Cycle | ANAPC2;DPF1;CDT1;ANAPC7;CEP152;CENPW;MCM6L;TSGA14;STAG1 |
| Cell Cycle, Mitotic | ENSA;ENSAA;NUF2;HIST4H4;ESCO1;CDK5RAP2;CEP70;NIPBLB;CEP57 |
| Cohesin Loading onto Chromatin | NIPBL;NIPBLA;PDS5B;MAU2;PDS5A;NIPBLB;STAG1;WAPAL;STAG2 |
| M Phase | CENPH;NCAPD2;KIF2B;ENSA;NSL1;ZW10;MASTL;CENPE;SGOL1 |
| Mitotic Telophase/Cytokinesis | NUDC;NIPBL;NIPBLB;MAU2;NIPBLA |
NIPBL has several biochemical functions, for example, chromatin binding, chromo shadow domain binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NIPBL itself. We selected most functions NIPBL had, and list some proteins which have the same functions with NIPBL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | CRTC2;HDAC5;CBX4;SMAD4;WHSC1;BAHD1;ARNTL1B;SATB1;Trl |
| chromo shadow domain binding | CHAF1A;LBR;TRIM28;ATRX;SP100;NIPBL |
| histone deacetylase binding | NUDT21;GCM1;ZNF703;HDAC1;D7ERTD443E;HIST1H1B;MAPK8;NRIP1;HDAC5 |
| mediator complex binding | NIPBL;SMC3;MED1;SMC1A |
| protein C-terminus binding | PPP2CA;SIAH1A;LIG4;FBLN1;MYO1C;AXIN1;SLC4A1;MRE11A;ITPR1 |
| protein N-terminus binding | VWF;TRP53;SMARCA4;KCNQ2;TARBP2;SMARCC1;ERCC3;ALOX5AP;ERCC6 |
| protein binding | PICK1;CC2D1B;ILVBL;FAM207A;CYCS;IL1RN;TNFRSF10A;HES1;INTS10 |
NIPBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NIPBL here. Most of them are supplied by our site. Hope this information will be useful for your research of NIPBL.
CBX5; CDK6; PRSS23; DBN1; fusA; pepP; adP1; RPL10; Cbx1; SNW1; Rpl35; LDHD; TFG; CDC5L; SUCO; MAU2
- Q&As
- Reviews
Q&As (6)
Ask a questionNIPBL mutations may cause chromosomal structural abnormalities and gene expression regulation defects, thereby affecting the expression patterns of multiple genes, resulting in the onset of CdLS patients.
Mutations in the NIPBL protein may lead to abnormalities in gene expression regulation and chromosomal structure, which in turn affect embryonic development and cell function, resulting in the occurrence of CdLS.
Current studies have found limited associations between NIPBL protein and other diseases or pathological processes, mainly related to CdLS.
Abnormalities in the NIPBL protein may affect the development of multiple systems, including facial features, intellectual development, cardiovascular system, etc.
NIPBL protein plays an important role in the regulation of chromosome topology and gene expression. It is involved in the formation of DNA ligation and mimicry structures, as well as the regulation of chromosome accessibility and gene transcription.
Different types of NIPBL protein mutations may result in different clinical phenotypes of CdLS and are correlated with the severity of the patient's clinical presentation.
Customer Reviews (3)
Write a reviewShort half-life and high clearance of NIPBL allow them to penetrate the tissue and reach the lesion site, improving the therapeutic effect.
Due to purity and bioactivity of the NIPBL's production process make it a valuable research tool.
The biological activity is high and the experimental effect is very good.
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