nipbl
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  • Official Full Name
  • NIPBL Nipped-B homolog (Drosophila)
  • Background
  • Background:The 26 S proteasome is a protein complex with a molecular mass of 2000 kDa. It is essential not only for eliminating damaged or misfolded proteins but also for degrading short lived regulatory proteins involved in cell cycle regulation DNA repair signal transduction apoptosis and metabolic regulation.Rpn3p is essential non-ATPase regulatory subunit of the 26S proteasome lid similar to the p58 subunit of the human 26S proteasome.
  • Synonyms
  • NIPBL; Nipped-B homolog (Drosophila); nipped-B-like protein; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; IDN3; Scc2; sister chromatid cohesion 2 homolog (yeast); delangin; SCC2 homolog; sister chromatid cohesion 2 homolog; CDLS; CDLS1; IDN3-B; FLJ44854;
Cat.#:NIPBL-5872HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NIPBL Protein, GST-tagged
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Cat.#:NIPBL-1296HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NIPBL, GST-tagged
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Cat.#:NIPBL-10676MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NIPBL Protein
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Involved Pathway

NIPBL involved in several pathways and played different roles in them. We selected most pathways NIPBL participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cohesin Loading onto Chromatin, which may be useful for your reference. Also, other proteins which involved in the same pathway with NIPBL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
HIST3H2BB; CDC14B; TOP2A; LIN37; CLIP1; SSNA1; YWHAE2; CDK6; CSNK2A1; CCND1
Cell Cycle, Mitotic
CENPJ; HIST3H2BB; ARPP19B; ESCO1; CENPO; CEP135; TOP2A; NUMA1; CDKN2A; FOXM1
Cohesin Loading onto Chromatin
NIPBLA; NIPBL; PDS5B; STAG1; PDS5A; NIPBLB; MAU2; STAG2; WAPAL
M Phase
ARPP19; USO1; APITD1; SGOL2; CLIP1; NEK9; CENPK; PANE1; RCC2; CNEP1R1
Mitotic Telophase/Cytokinesis
NUDC; NIPBL; NIPBLB; NIPBLA; MAU2

Protein Function

NIPBL has several biochemical functions, for example, chromatin binding, chromo shadow domain binding, histone deacetylase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NIPBL itself. We selected most functions NIPBL had, and list some proteins which have the same functions with NIPBL. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein TICRR; NCAPD2; SUZ12; SMARCC1; DMRT1; MKRN1; ING5; NFKB1; TOX4; ASH1L
Function chromo shadow domain binding
Related Protein TRIM28; LBR; ATRX; SP100; CHAF1A; NIPBL
Function histone deacetylase binding
Related Protein MYOCD; SRF; CBX5; KPNA2; SIX3; HDAC5; BCOR; TFAP4; MEF2D; BRMS1L
Function mediator complex binding
Related Protein SMC1A; NIPBL; MED1; SMC3
Function protein C-terminus binding
Related Protein BLOC1S2A; PIAS3; ATP2A2; HOMER3; SCLT1; HPCAL4; SIAH1; EP300; DYNLL1; VPS4B
Function protein N-terminus binding
Related Protein TARBP2; ARF6; STXBP1; KCNIP1; ACTN4; TBL1XR1; PARP1; MAU2; PDCD10; GLRX
Function protein binding
Related Protein NPAS2; RPS10; CACNG2; MEIS1; C2orf62; TRADD; TMUB2; TEX264; C10orf46; PACSIN1

Interacting Protein

NIPBL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NIPBL here. Most of them are supplied by our site. Hope this information will be useful for your research of NIPBL.
CBX5; CDK6; PRSS23; DBN1; fusA; pepP; adP1; RPL10; Cbx1; SNW1; Rpl35; LDHD; TFG; CDC5L; SUCO; MAU2