Recombinant Human NIPBL Protein, GST-tagged

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Recombinant Human NIPBL Protein, GST-tagged

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Cat.No. : NIPBL-5872H
Product Overview : Human NIPBL full-length ORF ( AAH33847.1, 1 a.a. - 175 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 45.9 kDa
AA Sequence : MKCLPENSAP LIEFANVSQG ILLLLMLKQH LKNLCGFSDS KIQKYSPSES AKVYDKAINR KTGVHFHPKQ TLDFLRSDMA NSKITEEVKR SIVKQYLDFK LLMEHLDPDE EEEEGEVSAS TNARNKAITS LLGGGSPKNN TAAETEDDES DGEDRGGGTS GVRRRRSQRI SQRIT
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing: :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : NIPBL Nipped-B homolog (Drosophila) [ Homo sapiens ]
Official Symbol : NIPBL
Synonyms : NIPBL; Nipped-B homolog (Drosophila); nipped-B-like protein; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; IDN3; Scc2; sister chromatid cohesion 2 homolog (yeast); delangin; SCC2 homolog; sister chromatid cohesion 2 homolog; CDLS; CDLS1; IDN3-B; FLJ44854;
Gene ID : 25836
mRNA Refseq : NM_015384
Protein Refseq : NP_056199
MIM : 608667
UniProt ID : Q6KC79

Products Types

◆ Recombinant Protein

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