Recombinant Human NIPBL Protein, GST-tagged

• Cat.No.: NIPBL-5872H
• Product Overview: Human NIPBL full-length ORF ( AAH33847.1, 1 a.a. - 175 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 45.9 kDa
• AA Sequence: MKCLPENSAPLIEFANVSQGILLLL MLKQHLKNLCGFSDSKIQKYSPSES AKVYDKAINRKTGVHFHPKQTLDFL RSDMANSKITEEVKRSIVKQYLDFK LLMEHLDPDEEEEEGEVSASTNARN KAITSLLGGGSPKNNTAAETEDDES DGEDRGGGTSGVRRRRSQRISQRIT
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NIPBL Nipped-B homolog (Drosophila) [ Homo sapiens ]
• Official Symbol: NIPBL
• Synonyms: NIPBL; Nipped-B homolog (Drosophila); nipped-B-like protein; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; IDN3; Scc2; sister chromatid cohesion 2 homolog (yeast); delangin; SCC2 homolog; sister chromatid cohesion 2 homolog; CDLS; CDLS1; IDN3-B; FLJ44854
• Gene ID: 25836
• mRNA Refseq: NM_015384
• Protein Refseq: NP_056199
• MIM: 608667
• UniProt ID: Q6KC79