NOTCH4 Protein, notch 4


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Official Full Name notch 4
Background This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
Synonyms NOTCH4; notch 4; INT3; NOTCH3; neurogenic locus notch homolog protein 4; Notch homolog 4;
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NOTCH4-523H Recombinant Human NOTCH4 Protein (Met1-Phe637), His-tagged Insect Cell His
    Human NOTCH4-120H Recombinant Human NOTCH4 protein, His-tagged E.coli His
    Human NOTCH4-309H Recombinant Human NOTCH4 Mammalian Cell His
    Rat Notch4-127R Recombinant Rat Notch4 protein, His-tagged E.coli His

    NOTCH4 involved in several pathways and played different roles in them. We selected most pathways NOTCH4 participated on our site, such as Dorso-ventral axis formation, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOTCH4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dorso-ventral axis formation MAP2K1; PIWIL1; SOS1; MAPK1; NOTCH3; PPP1R2P9; SPIRE1; SPIRE2; CPEB3; NOTCH2
    Notch signaling pathway NOTCH4; MFAP5; YY1; MYCBP; DLK1; PTCRA; LNX1; HES1; RBPJ; JAG1B
    Thyroid hormone signaling pathway MED12; SLC2A1; ATP1A3; ATP1B1; DIO3; KRAS; WNT4; TBC1D4; PLCG1; MDM2
    MicroRNAs in cancer BRCA1; PIK3CA; EZH2; ABL1; HRAS; ERBB3; RPS6KA5; CCND2; SERPINB5; PLCG2

    NOTCH4 has several biochemical functions, for example, Notch binding, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOTCH4 itself. We selected most functions NOTCH4 had, and list some proteins which have the same functions with NOTCH4. You can find most of the proteins on our site.

    Function Related Protein
    Notch binding DTX1; NOV; DLL3; GALNT11; JAG1A; JAG2; CHAC1; DNER; NOTCH1; C8orf4
    calcium ion binding CDH11; SLC25A23B; LTBP3; DMP1; SCUBE3; SDF4; PTBP3; CIB1; PLS3; RASGRP1
    protein binding CSNK1E; CHEK2; TSC22D3; EGR2; MRPS12; TRIM10; SIAH1; STXBP3A; UGGT1; USO1
    protein heterodimerization activity KCNB2; TAF8; BAK1; F11R.1; HIST1H2BI; LIMK1; PPARD; NPAS4; NKX2; MCL1A
    receptor activity GRIA2B; LRP2; NR2C2; IL18R1; RAMP3; PAQR5B; NOTCH1; PLXNA1; PVRL3B; ITGB1A

    NOTCH4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOTCH4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOTCH4.


    Lombardo, Y; Faronato, M; et al. Nicastrin and Notch4 drive endocrine therapy resistance and epithelial to mesenchymal transition in MCF7 breast cancer cells. BREAST CANCER RESEARCH 16:-(2014).
    Wu, WR; Shi, XD; et al. Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:3272-3279(2014).

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