p2rx1
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  • Official Full Name
  • purinergic receptor P2X, ligand-gated ion channel, 1
  • Background
  • The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
  • Synonyms
  • P2RX1; purinergic receptor P2X, ligand-gated ion channel, 1; P2X1; P2X purinoceptor 1; ATP receptor; P2X1 receptor; P2X receptor, subunit 1; purinergic receptor P2X1;
Cat.#:P2RX1-6088CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken P2RX1
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Cat.#:P2RX1-9886ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish P2RX1
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Cat.#:P2RX1-464HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human P2RX1 lysate
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Cat.#:CSC-RI0180Tag:
Source (Host):Species:Human
Product nameHuman P2RX1 Stable Cell Line-HEK293
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Cat.#:CSC-RI0181Tag:
Source (Host):Species:Human
Product nameHuman P2RX1 Stable Cell Line-HEK293
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Involved Pathway

P2RX1 involved in several pathways and played different roles in them. We selected most pathways P2RX1 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
NOS2A; AGTR1B; PPP3CA; CACNA1H; PPP3R2; PHKG1A; LTB4R2; CALM2B; EGFRA; PDGFRB
Neuroactive ligand-receptor interaction
MTNR1B; NPY7R; GRIA4A; GPR35; NPFFR1L3; S1PR5; GABBR1; PTGER2B; NTSR1; PTGER4C
Platelet activation
P2RX1; MAPK11; PRKCZ; GP5; PPP1R12A; PRKG1; ROCK1; AKT2; VAMP8; RAP1B

Protein Function

P2RX1 has several biochemical functions, for example, ATP binding, calcium channel activity, cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX1 itself. We selected most functions P2RX1 had, and list some proteins which have the same functions with P2RX1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PAK7; SIK3; CCT2; DHX37; CKM; TAOK1; MKKS; MTHFS; MINK1; RIPK4
Function calcium channel activity
Related Protein TRPC1; GRIN2A; CACNG7A; GRIN3A; P2RX1; CACNG8A; TRPN1; TRPC4A; PSEN1; CACFD1
Function cation channel activity
Related Protein FAM26D; TRPM1A; GRIN2C; TRPM1; ASIC1A; GRIN3B; MCOLN1; ASIC4A; TRPC1; GAR1
Function drug binding
Related Protein GABRA1; HTR2C; PDXK; IL2RA; DHODH; DRD1A; FOLR1; GSTP2; TOP2A; PPP3CB
Function extracellular ATP-gated cation channel activity
Related Protein P2RX7; P2RX8; P2RX5; P2RX4B; P2RX4; P2RX3A; P2RX2; P2RX1; P2RX6; NNR
Function purinergic nucleotide receptor activity
Related Protein P2RX8; P2RX3B; NNR; P2RX1; P2RX5; P2RX2; P2RX7; P2RX3A; P2RX4A; P2RX4
Function zinc ion binding
Related Protein CA9; RNF175; MMP8; PDXK; PMPCB; BMI1B; PRDM4; QPCTLA; TRIM105; PEX2