p4ha1
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  • Official Full Name
  • prolyl 4-hydroxylase, alpha polypeptide I
  • Background
  • This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • P4HA1; prolyl 4-hydroxylase, alpha polypeptide I; P4HA, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide I; prolyl 4-hydroxylase subunit alpha-1; C P4Halpha(I); collagen prolyl 4 hydroxylase alpha(I); 2-oxoglutarate-4-dioxygenase subunit alpha-1; 4-hydroxylase, alpha I subunit; 4-PH alpha-1; P4HA; P4HA1_HUMAN; Procollagen-proline; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I; C-P4Halpha(I); collagen prolyl 4-hydroxylase alpha(I); procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
Cat.#:P4HA1-30543THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human P4HA1
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Cat.#:P4HA1-3055THTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human P4HA1, MYC/DDK-tagged
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Cat.#:P4ha1-1177RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat P4ha1 protein, His & T7-tagged
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Cat.#:P4HA1-4240RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat P4HA1 Protein
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Cat.#:P4HA1-4216CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken P4HA1
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Cat.#:P4HA1-3482HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human P4HA1 293 Cell Lysate
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Cat.#:P4HA1-3483HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human P4HA1 293 Cell Lysate
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Involved Pathway

P4HA1 involved in several pathways and played different roles in them. We selected most pathways P4HA1 participated on our site, such as Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arginine and proline metabolism
ALDH3A2; SAT1A.1; CKMA; ALDH9A1B; SRM; CKMT2; DAO1; LSM1; P4HA3; HOGA1
Metabolic pathways
SAT2B; ADC; CBR1L; COX11; GLUD1B; SDHA; GNSB; PYGL; PIGH; GBA3

Protein Function

P4HA1 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA1 itself. We selected most functions P4HA1 had, and list some proteins which have the same functions with P4HA1. You can find most of the proteins on our site.
Function
Related Protein
Function L-ascorbic acid binding
Related Protein P3H2; FAM125B; LEPREL2; EGLN2; LEPREL1; P4HA3; EGLN3; PLOD1; TMLHE; P4HA1A
Function iron ion binding
Related Protein CYGB2; SC4MOL; CYP19A1B; PLOD2; CYP26C1; TYW5; PPEF1; CYP2P9; CYP4X1; NOS1
Function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Related Protein ALOX12E; ALOX8; ALOX5A; ADOB; P4HA3; P4HA1A; ALOX5B.3; ALOX5B.2; ADOA; ALOX12
Function procollagen-proline 4-dioxygenase activity
Related Protein P4HA3; P4HA2; P4HA1B; P4HA1A; P4HA1
Function protein binding
Related Protein CCT4; ZNHIT6; NUMA1; FBXL14; PMEPA1; ACOT7; EIF4H; GGPS1; ACO1; SFTPD

Interacting Protein

P4HA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA1.
HTT; MLF2; IRS4; Wiz; MYC; cona_canen; Cdk1; Naa50; FIP1L1; AATK; ZNF526; IRF7; HDAC10; UBA5; RNF41; SLAIN2