Recombinant Full Length Human P4HA1 Protein

• Cat.No.: P4HA1-355HF
• Product Overview: Recombinant full length Human P4HA1 with a N terminal proprietary tag; Predicted MWt 84.81 kDa including the tag.

Specification

• Description: This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 84.810kDa inclusive of tags
• Protein Length: 534 amino acids
• AA Sequence: MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVT SLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGH PVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKS FLTAEDCFELGKVAYTEADYYHTELWMEQALRQLDEGEIS TIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAV DYLPERQKYEMLCRGEGIKMTPRRQKKLFCRYHDGNRNPK FILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL RRATISNPITGDLETVHYRISKSAWLSGYENPVVSRINMR IQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDA FKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHER GQEFRRPCTLSELE
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: P4HA1 prolyl 4-hydroxylase, alpha polypeptide I [ Homo sapiens ]
• Official Symbol: P4HA1
• Synonyms: P4HA1; prolyl 4-hydroxylase, alpha polypeptide I; P4HA, procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide I; prolyl 4-hydroxylase subunit alpha-1; C P4Halpha(I); collagen prolyl 4 hydroxylase alpha(I)
• Gene ID: 5033
• mRNA Refseq: NM_000917
• Protein Refseq: NP_000908
• MIM: 176710
• UniProt ID: P13674