p4ha3
Share
  • Official Full Name
  • prolyl 4-hydroxylase, alpha polypeptide III
  • Background
  • This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
  • Synonyms
  • P4HA3; prolyl 4-hydroxylase, alpha polypeptide III; procollagen proline, 2 oxoglutarate 4 dioxygenase (proline 4 hydroxylase), alpha polypeptide III; prolyl 4-hydroxylase subunit alpha-3; C P4Halpha(III); collagen prolyl 4 hydroxylase alpha(III); 4-PH alpha-3; Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III; Procollagen-proline, 2-oxoglutarate 4-dioxygenase, alpha subunit, isoform 3; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3; Prolyl 4-hydroxylase, alpha-3 subunit; C-P4H alpha III; collagen prolyl 4-hydroxylase alpha(III)
Cat.#:P4HA3-1179HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HA3 protein, His & T7-tagged
+Inquiry
Cat.#:P4HA3-320HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HA3 Protein, His-tagged
+Inquiry
Cat.#:P4HA3-4241RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat P4HA3 Protein
+Inquiry
Cat.#:P4HA3-3480HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human P4HA3 293 Cell Lysate
+Inquiry

Involved Pathway

P4HA3 involved in several pathways and played different roles in them. We selected most pathways P4HA3 participated on our site, such as Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with P4HA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arginine and proline metabolism
MAOB; P4HA1B; SAT2; AOC1; ARG1; ALDH2; P4HA3; PYCRL; ABP1; GOT2A
Metabolic pathways
LDHB; GMDS; glpK; PYGL; HOGA1; GGT5A; MUT; PCYT1AB; CYP2C19; ATP6V1B1

Protein Function

P4HA3 has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HA3 itself. We selected most functions P4HA3 had, and list some proteins which have the same functions with P4HA3. You can find most of the proteins on our site.
Function
Related Protein
Function L-ascorbic acid binding
Related Protein PLOD2; P4HA1A; PLOD1; DBH; OGFOD1; FAM125B; PHYH; EGLN1B; PLOD1A; PLOD3
Function iron ion binding
Related Protein CYP1A4; ALKBH8; CYP7B1; AOX3L1; CYP1A; CYP4T8; CYP1B1; CYP4V8; CYP4F14; PPEF1
Function oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Related Protein P4HA1B; P4HA1; P4HA3; ALOX5B.3; ALOX5A; ADOB; ADOA; ALOX8; P4HA1A; ALOX12E
Function procollagen-proline 4-dioxygenase activity
Related Protein P4HA1A; P4HA1B; P4HA3; P4HA2; P4HA1
Function protein binding
Related Protein TRIM25; PPP2R1B; EXOC7; DUT; ACTR10; MMS22L; RARRES2; LRFN2; CD81; ADAMTS3

Interacting Protein

P4HA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HA3.
MEOX2; HGS; WDR62; SERTAD1; ZC3H12A; NUTM1; MAGEA2B

P4HA3 Related Articles

Li, L; Zhang, K; et al. Adiponectin Upregulates Prolyl-4-Hydroxylase alpha 1 Expression in Interleukin 6-Stimulated Human Aortic Smooth Muscle Cells by Regulating ERK 1/2 and Sp1. PLOS ONE 6:-(2011).
Pakkanen, O; Pirskanen, A; et al. Selective expression of nonsecreted triple-helical and secreted single-chain recombinant collagen fragments in the yeast Pichia pastoris. JOURNAL OF BIOTECHNOLOGY 123:248-256(2006).