p4htm
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  • Official Full Name
  • prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
  • Background
  • The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.
  • Synonyms
  • P4HTM; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); transmembrane prolyl 4-hydroxylase; EGLN4; FLJ20262; HIFPH4; hypoxia inducible factor prolyl 4 hydroxylase; P4H TM; PH 4; PH4; PHD4; Prolyl hydroxlase domain containing 4; HIF prolyl hydroxylase PH4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; Hypoxia inducible factor prolyl hydroxylase; Hypoxia-inducible factor prolyl hydroxylase 4; P4H with transmembrane domain; P4H-TM; P4HTM_HUMAN; Proline 4 hydroxylase; Prolyl 4 hydroxylase transmembrane (endoplasmic reticulum); OTTHUMP00000082685; OTTHUMP00000082686; proline 4-hydroxylase; Prolyl hydroxlase domain-containing 4; hypoxia; PH-4
Cat.#:P4HTM-1500HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P4HTM, GST-tagged
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Cat.#:P4HTM-3479HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human P4HTM 293 Cell Lysate
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Protein Function

P4HTM has several biochemical functions, for example, L-ascorbic acid binding, iron ion binding, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. Some of the functions are cooperated with other proteins, some of the functions could acted by P4HTM itself. We selected most functions P4HTM had, and list some proteins which have the same functions with P4HTM. You can find most of the proteins on our site.
Function
Related Protein
Function L-ascorbic acid binding
Related Protein DBH; OGFOD3; PHYH; P4HA2; TMLHE; PLOD1; P4HA1B; EGLN1; EGLN1B; LEPREL2
Function iron ion binding
Related Protein CYP4Z1; FTH1; AOX4; ALOX5B.3; CYP8B1; HBAE1; CYP4F18; BA1; CYP27C1; CYP4F14
Function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Related Protein ALKBH8; P4HTM; TYW5; KDM5D; KDM5BB; PHF8; ALKBH4; KDM5B; EGLN2; KDM5BA

Interacting Protein

P4HTM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P4HTM here. Most of them are supplied by our site. Hope this information will be useful for your research of P4HTM.
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