PABPN1 Protein, poly(A) binding protein, nuclear 1


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Official Full Name poly(A) binding protein, nuclear 1
Background This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3 ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5 end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
Synonyms PABPN1; poly(A) binding protein, nuclear 1; OPMD, PABP2, poly(A) binding protein, nuclear 1; polyadenylate-binding protein 2; PAB2; Nuclear poly(A) binding protein 1; PABII; PABP2; Poly(A) binding protein 2; Polyadenylate binding nuclear protein 1; Polyadenylate binding protein 2; ROX2; OTTHUMP00000164595; OTTHUMP00000164596; OTTHUMP00000246235; OTTHUMP00000246236; poly(A) binding protein II; OPMD; PABP-2
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PABPN1-403H Recombinant Human poly(A) binding protein, nuclear 1, His-tagged E.coli His
    Human PABPN1-5004H Recombinant Human PABPN1, His-tagged E.coli His
    Human PABPN1-586H Recombinant Human PABPN1 Mammalian Cell His
    Mouse PABPN1-12293M Recombinant Mouse PABPN1 Protein Mammalian Cell His
    Zebrafish PABPN1-12456Z Recombinant Zebrafish PABPN1 Mammalian Cell His
    Zebrafish PABPN1-5999Z Recombinant Zebrafish PABPN1 Mammalian Cell His
    CBCRY37 Polyadenylate-binding Protein 2 E.coli N/A

    PABPN1 involved in several pathways and played different roles in them. We selected most pathways PABPN1 participated on our site, such as mRNA surveillance pathway, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with PABPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA surveillance pathway CPSF6; PABPN1L; CASC3; PPP2R2A; PPP2R2B; PABPC1L2A; CSTF2T; UPF1; PPP2R5C; ETF1
    Influenza A TNFRSF10D; SOCS3; PIK3R5; NUP98; PIK3CB; HLA-DRA; LOC100033925; IL6; IFNA21; BLA

    PABPN1 has several biochemical functions, for example, RNA binding, nucleic acid binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PABPN1 itself. We selected most functions PABPN1 had, and list some proteins which have the same functions with PABPN1. You can find most of the proteins on our site.

    Function Related Protein
    nucleic acid binding GZF1; RNASE1; HNRNPA0L; ZBTB20; QKIA; CPEB1B; PABPC1B; EIF2C3; FOXP1B; NABP2
    nucleotide binding WNK2; UBE2IA; RBM12B; MAPK12A; ABCG2A; STK24A; MKI67IP; MARF1; HSP70; POLE
    poly(A) RNA binding PRAC; ANKHD1; NOC3L; LSM8; HIST1H4L; CLK3; RRP36; ALDOA; SLTM; SNRNP70
    protein self-association AGXT; CTSB; AGA; DVL2; PCSK9; PTH1R; CNTN2; SYP; ACVR2A; DYRK1A

    PABPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PABPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PABPN1.

    Mylk; Ywhae

    Impagliazzo, A; Tepper, AW; et al. Structural basis for a PABPN1 aggregation-preventing antibody fragment in OPMD. FEBS LETTERS 584:1558-1564(2010).
    Hahn, S; Nesslinger, NJ; et al. Castration induces autoantibody and T cell responses that correlate with inferior outcomes in an androgen-dependent murine tumor model. INTERNATIONAL JOURNAL OF CANCER 125:2871-2878(2009).

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