|Official Full Name||poly(A) binding protein, nuclear 1|
|Background||This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3 ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5 end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.|
|Synonyms||PABPN1; poly(A) binding protein, nuclear 1; OPMD, PABP2, poly(A) binding protein, nuclear 1; polyadenylate-binding protein 2; PAB2; Nuclear poly(A) binding protein 1; PABII; PABP2; Poly(A) binding protein 2; Polyadenylate binding nuclear protein 1; Polyadenylate binding protein 2; ROX2; OTTHUMP00000164595; OTTHUMP00000164596; OTTHUMP00000246235; OTTHUMP00000246236; poly(A) binding protein II; OPMD; PABP-2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PABPN1 involved in several pathways and played different roles in them. We selected most pathways PABPN1 participated on our site, such as mRNA surveillance pathway, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with PABPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|mRNA surveillance pathway||CPSF6; PABPN1L; CASC3; PPP2R2A; PPP2R2B; PABPC1L2A; CSTF2T; UPF1; PPP2R5C; ETF1|
|Influenza A||TNFRSF10D; SOCS3; PIK3R5; NUP98; PIK3CB; HLA-DRA; LOC100033925; IL6; IFNA21; BLA|
PABPN1 has several biochemical functions, for example, RNA binding, nucleic acid binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PABPN1 itself. We selected most functions PABPN1 had, and list some proteins which have the same functions with PABPN1. You can find most of the proteins on our site.
|RNA binding||EIF4E1C; IMPDH2; IGHMBP2; BAZ2A; HNRNPD; CELF6; PABPN1L; ACO1; FAM103A1; RTCA|
|nucleic acid binding||GZF1; RNASE1; HNRNPA0L; ZBTB20; QKIA; CPEB1B; PABPC1B; EIF2C3; FOXP1B; NABP2|
|nucleotide binding||WNK2; UBE2IA; RBM12B; MAPK12A; ABCG2A; STK24A; MKI67IP; MARF1; HSP70; POLE|
|poly(A) RNA binding||PRAC; ANKHD1; NOC3L; LSM8; HIST1H4L; CLK3; RRP36; ALDOA; SLTM; SNRNP70|
|poly(A) binding||HNRPDL; EIF4A3; ZC3H14; TIA1; SYNCRIP; KHDRBS2; PABPC1; RBPMS; DDX3X; KHDRBS1|
|protein self-association||AGXT; CTSB; AGA; DVL2; PCSK9; PTH1R; CNTN2; SYP; ACVR2A; DYRK1A|
PABPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PABPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PABPN1.