PAK3
-
Official Full Name
p21 protein (Cdc42/Rac)-activated kinase 3
-
Overview
PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
PAK3; p21 protein (Cdc42/Rac)-activated kinase 3; mental retardation, X linked 47 , MRX30, MRX47, p21 (CDKN1A) activated kinase 3; serine/threonine-protein kinase PAK 3; bPAK; hPAK3; PAK-3; beta-PAK; oligophrenin-3; p21-activated kinase 3; p21 (CDKN1A)-a;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Rat
- HEK293
- Insect (sf21)
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Sf9 insect cells
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- PAK3 Related Articles
- PAK3 Related Research Area
- PAK3 Related Signal Pathway
PAK3 involved in several pathways and played different roles in them. We selected most pathways PAK3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | SHC3;GAB1;SRC;PRKCBB;ERBB3B;MAPK3;PIK3CD;GRB2B;AREG |
| Ras signaling pathway | TEK;MAPK1;CALML3;PDGFA;ABL1;ANGPT1;PLA2G4A;KITLG;GNB3 |
| Axon guidance | CXCR4;GPC1B;DPYSL2B;RHOB;FGFR1B;CXCL12;PSPN;SEMA3B;PEA15A |
| Focal adhesion | FLT4;ACTN3B;FLT1;TLN2A;COL6A1;ITGA11A;FYNB;VEGFAB;PPP1R12A |
| T cell receptor signaling pathway | CABIN1;LCP2;ZAP70;RAF1;PDPK1;IL4;SLA1;CD8B;MAP2K1 |
| Regulation of actin cytoskeleton | ITGA4;CDC42L2;MYLPFB;ITGA3;MYL9B;ITGB1B.2;ARPC4L;PPP1CC;VAV3 |
| Renal cell carcinoma | MAP2K1;TGFB1;PAK6;FH;PAK1;TGFA;TCEB1;PIK3CD;HRAS |
PAK3 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK3 itself. We selected most functions PAK3 had, and list some proteins which have the same functions with PAK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | KIF3CB;HSPD1;MAPK7;ABCG4B;MAT1A;JAK1;DDX51;NLRX1;GRK1 |
| MAP kinase kinase activity | MAP3K9;MAP2K2;LRRK2;MAP2K2A;MAP2K2B;MAP2K6;MAPK10;MAPKAPK5;MAP2K3 |
| Rac GTPase binding | CORO1C;SRGAP3;RAB7;PAK2;DOCK7;NOXA1;ITPKA;PAK4;SRGAP2 |
| SH3 domain binding | WIPF3;PTTG1;NCKIPSD;ARHGAP27;PAK3;ITGB1BP2;CBLC;VASPA;INPP5D |
| metal ion binding | ZNF701;EXT1;ZNF554;ZNF471;CYP2C55;CPXCR1;RNF148;IDS;ZNF839 |
| protein binding | RUFY4;C12orf68;CD2BP2;TRPC4AP;DUSP21;BACH1;DNAJB4;MGST1;BAZ1A |
| protein serine/threonine kinase activity | PAK2B;ICK;NEK11;CAMK1DB;ROCK1;BMPR1BA;STRC;PIM1;GM7168 |
PAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK3.
RAC1; CDC42; PLK1; CDC42; STK4
- Q&As
- Reviews
Ask a Question for All PAK3 Products
Required fields are marked with *
My Review for All PAK3 Products
Required fields are marked with *
