pak3
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  • Official Full Name
  • p21 protein (Cdc42/Rac)-activated kinase 3
  • Background
  • PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms
  • PAK3; p21 protein (Cdc42/Rac)-activated kinase 3; mental retardation, X linked 47 , MRX30, MRX47, p21 (CDKN1A) activated kinase 3; serine/threonine-protein kinase PAK 3; bPAK; hPAK3; PAK-3; beta-PAK; oligophrenin-3; p21-activated kinase 3; p21 (CDKN1A)-a
Cat.#:PAK3-379HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK3, GST-tagged, Active
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Cat.#:PAK3-722HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK3, GST-His
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Cat.#:PAK3-1354HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PAK3, His tagged
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Cat.#:PAK3-4261RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAK3 Protein
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Cat.#:PAK3-517HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PAK3 cell lysate
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Involved Pathway

PAK3 involved in several pathways and played different roles in them. We selected most pathways PAK3 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PIK3R1; GRB2B; ABL2; PIK3R3A; PRKCA; CDKN1BA; CAMK2D; PIK3CA; PAK3; MTOR
Ras signaling pathway
PIK3CB; ZAP70; FGF12; FGF4; FGF5; GNG10; INS2; LOC608458; KIT; GRIN2A
Axon guidance
NRAS; PLXNB2; ITSN1; NCK2; PLXNA1; EFNB3B; PAK6; LOC608458; UNC5C; KBTBD7
Focal adhesion
CAPN2; PXNA; FYNA; IBSP; PTK2; PTK2AB; RAF1A; PTK2AA; MAPK4; TNR
T cell receptor signaling pathway
CD3G; VAV1; CARD11; ICOS; IL5; LCK; NFATC3; CBL; HRAS; PDPK1
Regulation of actin cytoskeleton
ITGA11A; PFN2L; CDC42L; RRAS2; TMSB4X; ITGAL; FN1A; WASF1; F2R; ITGB1A
Renal cell carcinoma
AKT2; AKT1; EP300; AHA-1; SOS1; TGFB3; PIK3R1; MAPK3; CUL2; PIK3CA

Protein Function

PAK3 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK3 itself. We selected most functions PAK3 had, and list some proteins which have the same functions with PAK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYH6; CDK8; IP6K2; CDK18; CLK2; Fert2; ERCC6L2; MYH1E; MYO1E; FGFR1A
Function MAP kinase kinase activity
Related Protein MAP2K2A; PAK3; MAP2K3; MAP3K20; MAP2K2; MAPK10; MAPK14; MAP2K6; MAP2K1; MAP3K14
Function Rac GTPase binding
Related Protein PAK6; PAK7; PAK1; SRGAP1; PAK2B; PAK2; PAK2A; PAK4; ARHGAP4A; CAV1
Function SH3 domain binding
Related Protein PDCD6IP; ARHGAP1; USP8; CD2AP; EVL; SH3BP1; ADAM17; CBLC; INPPL1; DENND1A
Function metal ion binding
Related Protein TRIM35-1; PDZRN3B; FTR54; TM9SF1; ACVR1C; CDK2; ZFP354A; ACO1; SIAH1A; TENC1
Function protein binding
Related Protein PLK1S1; KCND3; FANCG; SIP1; PTPN11; RPAP1; C7orf49; SFRP4; C22orf23; N4BP2L2
Function protein serine/threonine kinase activity
Related Protein MARK4; NEK7; BMPR1AA; PIM3; MINK1; KALRN; ULK1; ULK4; BMPR2B; ADCK4

Interacting Protein

PAK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK3.
RAC1; CDC42; PLK1; CDC42; STK4

PAK3 Related Articles

Kreis, P; Rousseau, V; et al. The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties. JOURNAL OF NEUROCHEMISTRY 106:1184-1197(2008).
McFawn, PK; Shen, L; et al. Calcium-independent contraction and sensitization of airway smooth muscle by p21-activated protein kinase. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 284:L863-L870(2003).