• Official Full Name
  • proprotein convertase subtilisin/kexin type 4
  • Background
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. [provided by RefSeq, Jan 2014]
  • Synonyms
  • PCSK4; proprotein convertase subtilisin/kexin type 4; PC4; SPC5;
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PCSK4, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PCSK4 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PCSK4 Protein
Source (Host):Species:Human
Product nameRecombinant Human PCSK4 cell lysate

Protein Function

PCSK4 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK4 itself. We selected most functions PCSK4 had, and list some proteins which have the same functions with PCSK4. You can find most of the proteins on our site.
Related Protein
Function serine-type endopeptidase activity
Related Protein TMPRSS12; PRSS48; PRSS57; KLK1B11; KLK15; KLK4; HPN; KLK1B24; GZMH; KLK1B22

PCSK4 Related Articles

Raal, FJ; Honarpour, N; et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. LANCET 385:341-350(2015).
Moriarty, PM; Jacobson, TA; et al. Efficacy and safety of alirocumab, a monoclonal antibody to PCSK9, in statin-intolerant patients: Design and rationale of ODYSSEY ALTERNATIVE, a randomized phase 3 trial. JOURNAL OF CLINICAL LIPIDOLOGY 8:554-561(2014).