PDK4

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PDK4

Official Full Name pyruvate dehydrogenase kinase, isozyme 4
Background This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]
Synonyms PDK4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDK4-1073H Recombinant Human PDK4 Protein, GST-tagged Insect cells GST
    Human PDK4-29137TH Recombinant Human PDK4, His-tagged E.coli His
    Human PDK4-29138TH Recombinant Human PDK4 Wheat Germ N/A
    Human PDK4-5669H Recombinant Human PDK4 protein, His & T7-tagged E.coli His/T7
    Human PDK4-653H Recombinant Human PDK4, His-tagged E.coli His
    Human PDK4-823H Recombinant Human PDK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse PDK4-001MCL Recombinant Mouse PDK4 cell lysate Insect Cell N/A
    Mouse Pdk4-525M Recombinant Mouse Pdk4, His & GST-tagged Insect Cell His/GST
    Mouse Pdk4-5670M Recombinant Mouse Pdk4 protein, His & T7-tagged E.coli His/T7
    Rat PDK4-4350R Recombinant Rat PDK4 Protein Mammalian Cell His
    Chicken PDK4-4481C Recombinant Chicken PDK4 Mammalian Cell His
    Zebrafish PDK4-6990Z Recombinant Zebrafish PDK4 Mammalian Cell His

    PDK4 involved in several pathways and played different roles in them. We selected most pathways PDK4 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism SCO1; TPMT.2; NDUFS7; ACOT9; CYP3A7-CYP3AP1; APOF; MTP; CTRC; LRPPRC; PNPLA8
    Pyruvate metabolism PDHB; PKM; PDK3B; ACSS2L; ACAT2; ME3; PDK3; PDHA1B; ACYP1; ACSS2
    Pyruvate metabolism and Citric Acid (TCA) cycle PDPR; SLC16A8; PDP2; SLC16A1; BRP44; ADHFE1; D2HGDH; PDK4; MPC1; PDK3
    Regulation of pyruvate dehydrogenase (PDH) complex PDK3; PDP2; PDPR; PDK2; PDK3B; PDK2B; PDK4; PDP1
    Signal Transduction APOM; RGS9BP; RDH14B; CLIP3; MYO7A; LGR4; IGF2BP1; ARHGEF1B; SOX9B; RGS21
    Signaling by Retinoic Acid PDK4; CRABP1; RARG; ALDH8A1; CRABP2; PDK2; RDH14A; RDH13; RDH7; RDH14B
    The citric acid (TCA) cycle and respiratory electron transport ETFB; ETFA; C20orf7; SCO1; SURF1; NDUFAF7; PDK2; UCP2; COX14; PDK4

    PDK4 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK4 itself. We selected most functions PDK4 had, and list some proteins which have the same functions with PDK4. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding LATS1; TEC; ACVR2A; NLRP3; HK2; EIF2AK2; RAD51D; ATP8B1; Atp8a2; TRIP13
    protein kinase activity GSG2; MAPKAPK2; JAK2; ERBB4A; SNRKB; PIK3R4; ABL2; NLK2; AKT3; MAPK8B
    pyruvate dehydrogenase (acetyl-transferring) kinase activity PDK1; PDK2; PDK4; PDK3

    PDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK4.

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    Harada, K; Kakuda, Y; et al. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. JOURNAL OF CLINICAL PATHOLOGY 67:396-402(2014).
    Araki, M; Nozaki, Y; et al. Transcriptional regulation of metabolic switching PDK4 gene under various physiological conditions. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 127:153-162(2007).

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