pdk4
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  • Official Full Name
  • pyruvate dehydrogenase kinase, isozyme 4
  • Background
  • This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PDK4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial;
Cat.#:PDK4-823HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDK4 Protein, MYC/DDK-tagged
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Cat.#:PDK4-653HTag:His
Source (Host):BacteriaSpecies:Human
Product nameRecombinant Human PDK4, His-tagged
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Cat.#:PDK4-29137THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDK4, His-tagged
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Cat.#:PDK4-29138THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PDK4
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Cat.#:PDK4-5669HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDK4 protein, His & T7-tagged
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Cat.#:Pdk4-525MTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Pdk4, His & GST-tagged
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Cat.#:Pdk4-5670MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pdk4 protein, His & T7-tagged
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Cat.#:PDK4-4350RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDK4 Protein
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Cat.#:PDK4-4481CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDK4
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Cat.#:PDK4-6990ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PDK4
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Cat.#:PDK4-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse PDK4 cell lysate
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Involved Pathway

PDK4 involved in several pathways and played different roles in them. We selected most pathways PDK4 participated on our site, such as Metabolism, Pyruvate metabolism, Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK4 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism
CTRB1; BHMT2; ISCUB; COX15; MOCOS; DPEP2; SLC23A2; MED6; APOA5; DPYS
Pyruvate metabolism
FH; PDK2B; ALDH9A1; MDH2; PCK1; ACSS2L; ALDH2.1; ACYP2; LDHD; HAGHL
Pyruvate metabolism and Citric Acid (TCA) cycle
PDP2; BRP44; PDK2B; D2HGDH; PDP1; SLC16A8; MPC1; PDK3; PDK2; PDK4
Regulation of pyruvate dehydrogenase (PDH) complex
PDP2; PDP1; PDK4; PDK2B; PDPR; PDK3; PDK3B; PDK2
Signal Transduction
RGR; PRLRB; TAX1BP3; RPE65B; KAL1; CHN1; ARHGAP44; ARHGAP19; HCRT; PTH
Signaling by Retinoic Acid
RDH10; PDK3B; RDH14B; RARGA; CRABP1; CRABP2A; PDK3; RDH7; DHRS3; FABP11A
The citric acid (TCA) cycle and respiratory electron transport
COX14; NDUFAF7; SCO1; ADHFE1; ATP5S; TIMMDC1; BRP44; PDK3B; LRPPRC; PDK4

Protein Function

PDK4 has several biochemical functions, for example, ATP binding, protein kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK4 itself. We selected most functions PDK4 had, and list some proteins which have the same functions with PDK4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RAD51L1; Adcy4; SMARCA2; RIPK1; SGK3; HLCS; MKNK1; P2RX1; STK11; RPS6KB2
Function protein kinase activity
Related Protein NPR1A; CDKL2; LMTK3; PRKCBB; STK25; IKBKAP; MAPKAPK2; STK26; ROCK2B; PRKCDA
Function pyruvate dehydrogenase (acetyl-transferring) kinase activity
Related Protein PDK3; PDK4; PDK2; PDK1

Interacting Protein

PDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK4.
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PDK4 Related Articles

Harada, K; Kakuda, Y; et al. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. JOURNAL OF CLINICAL PATHOLOGY 67:396-402(2014).
Araki, M; Nozaki, Y; et al. Transcriptional regulation of metabolic switching PDK4 gene under various physiological conditions. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 127:153-162(2007).