|Official Full Name||pyruvate dehydrogenase kinase, isozyme 4|
|Background||This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]|
|Synonyms||PDK4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PDK4 involved in several pathways and played different roles in them. We selected most pathways PDK4 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Metabolism||SCO1; TPMT.2; NDUFS7; ACOT9; CYP3A7-CYP3AP1; APOF; MTP; CTRC; LRPPRC; PNPLA8|
|Pyruvate metabolism||PDHB; PKM; PDK3B; ACSS2L; ACAT2; ME3; PDK3; PDHA1B; ACYP1; ACSS2|
|Pyruvate metabolism and Citric Acid (TCA) cycle||PDPR; SLC16A8; PDP2; SLC16A1; BRP44; ADHFE1; D2HGDH; PDK4; MPC1; PDK3|
|Regulation of pyruvate dehydrogenase (PDH) complex||PDK3; PDP2; PDPR; PDK2; PDK3B; PDK2B; PDK4; PDP1|
|Signal Transduction||APOM; RGS9BP; RDH14B; CLIP3; MYO7A; LGR4; IGF2BP1; ARHGEF1B; SOX9B; RGS21|
|Signaling by Retinoic Acid||PDK4; CRABP1; RARG; ALDH8A1; CRABP2; PDK2; RDH14A; RDH13; RDH7; RDH14B|
|The citric acid (TCA) cycle and respiratory electron transport||ETFB; ETFA; C20orf7; SCO1; SURF1; NDUFAF7; PDK2; UCP2; COX14; PDK4|
PDK4 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK4 itself. We selected most functions PDK4 had, and list some proteins which have the same functions with PDK4. You can find most of the proteins on our site.
|ATP binding||LATS1; TEC; ACVR2A; NLRP3; HK2; EIF2AK2; RAD51D; ATP8B1; Atp8a2; TRIP13|
|protein kinase activity||GSG2; MAPKAPK2; JAK2; ERBB4A; SNRKB; PIK3R4; ABL2; NLK2; AKT3; MAPK8B|
|pyruvate dehydrogenase (acetyl-transferring) kinase activity||PDK1; PDK2; PDK4; PDK3|
PDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK4.