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PDK4

  • Official Full Name

    pyruvate dehydrogenase kinase, isozyme 4

  • Overview

    This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]
  • Synonyms

    PDK4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDK4-29138TH Recombinant Human PDK4 Wheat Germ N/A 411 amino acids
Human PDK4-5669H Recombinant Human PDK4 protein, His & T7-tagged E.coli His/T7 Asp73~Thr316 (Accession # Q16654)
Human PDK4-653H Recombinant Human PDK4, His-tagged E.coli His
Human PDK4-29137TH Recombinant Human PDK4, His-tagged E.coli His 401 amino acids
Human PDK4-1073H Active Recombinant Human PDK4 Protein, GST-tagged Insect cells GST
Human PDK4-823H Recombinant Human PDK4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PDK4-9543HF Active Recombinant Full Length Human PDK4 Protein, GST-tagged E.coli GST 1-411
Human PDK4-369HF Recombinant Full Length Human PDK4 Protein In Vitro Cell Free System 411 amino acids
Human PDK4-0622H Recombinant Human PDK4 Protein (M1-M411), GST tagged E.coli GST M1-M411
Human PDK4-683HFL Recombinant Full Length Human PDK4 Protein, C-Flag-tagged Mammalian cells Flag
Human PDK4-1640H-B Recombinant Human PDK4 Protein Pre-coupled Magnetic Beads HEK293
Human PDK4-1640H Recombinant Human PDK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDK4-0621H Recombinant Human PDK4 Protein (M1-M411), Tag Free E.coli No tag M1-M411
Mouse Pdk4-5670M Recombinant Mouse Pdk4 protein, His & T7-tagged E.coli His/T7 Val117~Gln387 (Accession # O70571)
Mouse Pdk4-525M Recombinant Mouse Pdk4, His & GST-tagged Insect Cell His/GST Met1-Val412
Mouse PDK4-001MCL Recombinant Mouse PDK4 cell lysate Insect Cell N/A
Mouse Pdk4-3329M Recombinant Mouse Pdk4 protein, His-tagged E.coli His 138-368aa
Mouse Pdk4-4769M Recombinant Mouse Pdk4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PDK4-4350R Recombinant Rat PDK4 Protein Mammalian Cell His
Rat PDK4-4010R Recombinant Rat PDK4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PDK4-4010R-B Recombinant Rat PDK4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PDK4-6990Z Recombinant Zebrafish PDK4 Mammalian Cell His
Chicken PDK4-4481C Recombinant Chicken PDK4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDK4 Related Articles
  • PDK4 Related Research Area

PDK4 involved in several pathways and played different roles in them. We selected most pathways PDK4 participated on our site, such as Metabolism, Pyruvate metabolism, Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MetabolismGSTO2;BCHE;SCP2B;GLTPD1;GCKR;BHMT2;CYP2C18;MED22;CYP2AD3
Pyruvate metabolismFH;PDP1;ALDH2;PDHA1B;FH1;ACOT12;SLC16A1;ALDH3A2;PDK2B
Pyruvate metabolism and Citric Acid (TCA) cyclePDPR;D2HGDH;SLC16A8;MPC1;ADHFE1;PDP2;SLC16A1;PDK4;PDK2B
Regulation of pyruvate dehydrogenase (PDH) complexPDK3B;PDK4;PDK3;PDP2;PDK2B;PDK2;PDP1;PDPR
Signal TransductionPPY;DHRS9;BCO2L;SOX9A;TAX1BP1B;OXGR1;NMT1A;OR52J3;GPR39
Signaling by Retinoic AcidSDR16C5;RARGA;DHRS9;RDH10;PDK2B;PDK3;CRABP1;PDK2;RARG
The citric acid (TCA) cycle and respiratory electron transportPDP1;PDP2;ETFA;ETFDH;COX18;PDK2;PDK3B;SLC25A27;NDUFAF6

PDK4 has several biochemical functions, for example, ATP binding, protein kinase activity, pyruvate dehydrogenase (acetyl-transferring) kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK4 itself. We selected most functions PDK4 had, and list some proteins which have the same functions with PDK4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPTK7;PTK7A;GLULC;DDX39B;CCT8;ATP8B1;DYRK4;TRIO;TWF2
protein kinase activityNTRK3A;STK25A;CDC7;Fert2;AKT3A;cka1;PRKAB1;DCKL1B;NRBP2
pyruvate dehydrogenase (acetyl-transferring) kinase activityPDK4;PDK1;PDK2;PDK3

PDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK4.

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Harada, K; Kakuda, Y; et al. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. JOURNAL OF CLINICAL PATHOLOGY 67:396-402(2014).
Araki, M; Nozaki, Y; et al. Transcriptional regulation of metabolic switching PDK4 gene under various physiological conditions. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 127:153-162(2007).
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