per1
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  • Official Full Name
  • period homolog 1 (Drosophila)
  • Background
  • This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
  • Synonyms
  • PER1; period homolog 1 (Drosophila); PER, period (Drosophila) homolog 1; period circadian protein homolog 1; RIGUI; Circadian clock protein PERIOD 1; Circadian clock protein PERIOD1; Circadian pacemaker protein RIGUI; hPER 1; hPER; hPER1; KIAA0482; MGC88021; PER 1; PER; PER1 protein; Period 1; Period drosophila homolog of; Period homolog 1; Period1; Period, drosophila, homolog of
Cat.#:PER1-1645HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PER1, GST-tagged
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Cat.#:PER1-1923HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PER1 protein, His & T7-tagged
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Cat.#:PER1-12635MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PER1 Protein
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Cat.#:PER1-4377RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PER1 Protein
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Cat.#:PER1-1332HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PER1 cell lysate
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Involved Pathway

PER1 involved in several pathways and played different roles in them. We selected most pathways PER1 participated on our site, such as Circadian rhythm, Circadian entrainment, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PER1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Circadian rhythm
CUL1; PRKAG2; BTRC; SKP1; FBXL3; CRY1; NPAS2; FBXW11; CLOCK; CSNK1E
Circadian entrainment
GRIN2A; GNG4; GNG13; PLCB2; RPS6KA5; CAMK2G; PRKACG; PLCB4; PRKCG; PRKG1
Herpes simplex infection
CASP3A; CFP; C1QBP; OAS1A; TLR2; IFNG1-2; Casp3; MYD88; NXF3; SFRS3B

Protein Function

PER1 has several biochemical functions, for example, E-box binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PER1 itself. We selected most functions PER1 had, and list some proteins which have the same functions with PER1. You can find most of the proteins on our site.
Function
Related Protein
Function E-box binding
Related Protein TFAP4; TCF3; MYC; LMO2; ARNTL; NEUROG1; TWIST1; ASCL1; ATOH8; GATA3
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein HINFP; MTF1; PRDM1; NKX6; HOXA7; ELK3; POU2F2; PAX8; FEZF2; FOXJ2
Function chromatin DNA binding
Related Protein INSM1A; RARA; GRHL3; MYOD1; H1F0; ZIC2; H2AFY; FOXO3; VAX1; HDAC3
Function kinase binding
Related Protein PARK2; CTNNB1; STRADA; HSP90AB1; BARD1; CAB39; SGOL1; BTG1; WWC1; TOLLIP
Function transcription factor activity, transcription factor binding
Related Protein ASCL1; LDB2A; HIF1A; ASCL1A; TRP63; LDB1B; ASCL1B; NEUROG1; LDB2B; MTA2
Function transcription factor binding
Related Protein PYDC3; ZFPM1; NKX2-5; GATA6; PARD6A; HDAC7; SRF; KCTD1; KEAP1B; SNF8
Function ubiquitin protein ligase binding
Related Protein ZFP746; PIAS4; TRIM37; BCL2; RELA; MDM2; TXNIP; ANAPC2; SMAD7; PARK2

Interacting Protein

PER1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PER1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PER1.
Cry1; CSNK1E; Csnk1e; TNS2; FAM65B; Csnk1d; GTSE1

PER1 Related Articles

Ait-Hmyed, O; Felder-Schmittbuhl, MP; et al. Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defects. EUROPEAN JOURNAL OF NEUROSCIENCE 37:1048-1060(2013).
LeSauter, J; Lambert, CM; et al. Antibodies for Assessing Circadian Clock Proteins in the Rodent Suprachiasmatic Nucleus. PLOS ONE 7:-(2012).