phf5a
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  • Official Full Name
  • PHD finger protein 5A
  • Background
  • This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the introns branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes.
  • Synonyms
  • PHF5A; PHD finger protein 5A; PHD finger-like domain-containing protein 5A; bK223H9.2; INI; MGC1346; Rds3; SAP14b; SF3b14b; PHD finger like domain containing protein 5A; 1110007B08Rik; Ac2 246; OTTHUMP00000198827; PHD finger 5a; PHD finger like domain protein 5A; PHD finger-like domain protein 5A; PHF5A_HUMAN; Splicing factor 3B associated 14 kDa protein; Splicing factor 3B-associated 14 kDa protein; Transcription factor INI; PHD-finger 5a
Cat.#:PHF5A-1681HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PHF5A, GST-tagged
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Cat.#:PHF5A-213HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PHD finger protein 5A, His-tagged
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Cat.#:PHF5A-12730MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PHF5A Protein
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Cat.#:PHF5A-4790CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PHF5A
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Cat.#:PHF5A-9538ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PHF5A
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Cat.#:PHF5A-3226HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PHF5A 293 Cell Lysate
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Involved Pathway

PHF5A involved in several pathways and played different roles in them. We selected most pathways PHF5A participated on our site, such as Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHF5A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Spliceosome
SRSF2A; DDX23; TCERG1A; CCDC12; SNRPE; SNRPG; HSP70L; HNRNPM; SYF2; MAGOHB

Protein Function

PHF5A has several biochemical functions, for example, DNA binding, poly(A) RNA binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHF5A itself. We selected most functions PHF5A had, and list some proteins which have the same functions with PHF5A. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HIST1H2BH; HMGB3B; MKXA; ZHX1; ZNF764; NUFIP1; ZBTB9; SIX4A; IRF6; DRGX
Function poly(A) RNA binding
Related Protein NQO1; PATL1; DZIP3; MAK16; ELAC2; CLNS1A; KIAA1324; SUGP2; SRSF12; SUGP1
Function transcription factor activity, sequence-specific DNA binding
Related Protein POU3F4; FOXO6; MYPOP; RELA; HOXA4A; POU2F2; TBX6; RUNX1; ZBTB25; GABPA

Interacting Protein

PHF5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHF5A here. Most of them are supplied by our site. Hope this information will be useful for your research of PHF5A.
SF3A2; Sf3a1; ZDHHC17; PRPF31; FOXB1; ssrna_ag; PTBP3; Lck; PPP3CB; VCAM1; EMC2; CHST15; AGO1; SRPK3

PHF5A Related Articles

Zhang, CC; He, L; et al. Screening of cellular proteins that interact with the classical swine fever virus non-structural protein 5A by yeast two-hybrid analysis. JOURNAL OF BIOSCIENCES 39:63-74(2014).
Falck, E; Klinga-Levan, K; et al. Expression patterns of Phf5a/PHF5A and Gja1/GJA1 in rat and human endometrial cancer. CANCER CELL INTERNATIONAL 13:-(2013).