pi4k2a
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  • Official Full Name
  • phosphatidylinositol 4-kinase type 2 alpha
  • Background
  • Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell;growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4;position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 (PubMed 11244087)).
  • Synonyms
  • PI4K2A; phosphatidylinositol 4-kinase type 2 alpha; phosphatidylinositol 4-kinase type 2-alpha; DKFZP761G1923; PI4KII; PIK42A; phosphatidylinositol 4-kinase type II-alpha; phosphatidylinositol 4-kinase type II (PI4KII); RP11-548K23.6
Cat.#:PI4K2A-1075Tag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PI4K2A protein, GST-tagged
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Cat.#:PI4K2A-1075HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PI4K2A, GST-tagged
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Cat.#:PI4K2A-159HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PI4K2A protein, GST-tagged, Active
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Cat.#:PI4K2A-1698HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PI4K2A, His-tagged
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Cat.#:PI4K2A-30365THTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PI4K2A
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Cat.#:PI4K2A-12763MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PI4K2A Protein
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Cat.#:PI4K2A-4437RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PI4K2A Protein
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Cat.#:PI4K2A-12538ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PI4K2A
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Cat.#:PI4K2A-1450HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PI4K2A (Active), GST-tagged
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Cat.#:PI4K2A-1350HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PI4K2A cell lysate
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Involved Pathway

PI4K2A involved in several pathways and played different roles in them. We selected most pathways PI4K2A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PI4K2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
ITPK1; PTENB; TPI1A; MTMR3; PIP5K2; PI4KB; PIP4K2B; MINPP1A; INPP4A; MTMR4
Metabolic pathways
MCCC2; PLA2G10; ADH1; URAH; B3GALT6; KL; IDH3G; ITPKB; FAHD1; FUT5
Phosphatidylinositol signaling system
PIP5K1BA; ITPKB; PIK3C2B; MTMR8; PIK3CB; CDS1; MTMR7; PI4KAA; PLCB3; IMPAD1

Protein Function

PI4K2A has several biochemical functions, for example, 1-phosphatidylinositol 4-kinase activity, AP-3 adaptor complex binding, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PI4K2A itself. We selected most functions PI4K2A had, and list some proteins which have the same functions with PI4K2A. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol 4-kinase activity
Related Protein PI4K2A; PI4K2B; PI4KA; PI4KAA; PI4KB; PI4KAB
Function AP-3 adaptor complex binding
Related Protein RAB32; RAB38; PI4K2A
Function ATP binding
Related Protein NTRK2B; PDGFRA; GRK1B; GRK4; CAMKVB; PSMC1B; ARAF; AK9; TTN; COASY
Function magnesium ion binding
Related Protein GTPBP10; NUAK2; STK11; SERPINB1A; PKMB; RPS6KA3B; MTHFD2; NUDT5; PRTFDC1; IDH2
Function protein binding
Related Protein SCAF8; FAM60A; HSPA12B; PSMB8; KIAA1109; ATP6V0A1; CCT2; SPHK1; ZFPM2; TMEM147

Interacting Protein

PI4K2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PI4K2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PI4K2A.
ITCH; GABARAP; NOS3; RAD23A; CNOT1; PHF8

PI4K2A Related Articles

Lemos, T; Verdoorn, KS; et al. Biphasic regulation of type II phosphatidylinositol-4 kinase by sphingosine: Cross talk between glycero- and sphingolipids in the kidney. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1838:1003-1009(2014).
Szentpetery, Z; Szakacs, G; et al. Genetic and functional studies of phosphatidyl-inositol 4-kinase type III alpha. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1811:476-483(2011).