pip5k1a
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  • Official Full Name
  • phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
  • Background
  • Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. Contributes to the activation of PLD2.
  • Synonyms
  • PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; PIP5KIalpha; PIP5K1-alpha; ptdIns(4)P-5-kinase 1 alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
Cat.#:PIP5K1A-170HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIP5K1A protein, GST-tagged, Active
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Cat.#:PIP5K1A-1727HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIP5K1A, GST-tagged
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Cat.#:PIP5K1A-12828MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIP5K1A Protein
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Cat.#:PIP5K1A-3893CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIP5K1A
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Cat.#:PIP5K1A-1082HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, GST-tagged
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Cat.#:PIP5K1A-1460HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIP5K1A (Active), GST-tagged
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Cat.#:PIP5K1A-3173HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PIP5K1A 293 Cell Lysate
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Involved Pathway

PIP5K1A involved in several pathways and played different roles in them. We selected most pathways PIP5K1A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIP5K1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
MTMR4; IPMKB; ITPK1A; MTMR8; PIP4K2A; INPP5K; MINPP1B; PIK3C2B; PLCD3; PLCB1
Metabolic pathways
GGT6; ADK; ASAH1A; PPAT; GMDS; GALNT2; ALDH3B2; MGAT2; ENO1; MAN1B1
Phosphatidylinositol signaling system
PIK3C3; DGKE; IP6K3; CALM1A; PI4KA; IP6K2; IPMKB; CDS1; IMPA2; MTMR14
Phospholipase D signaling pathway
MAP2K2; CYTH1; MS4A2; LPAR5; HRAS; INSR; TSC1; AGPAT4; DGKZ; PIK3R1
Endocytosis
WASL; PDGFRA; CYTH1B; TFRC; BF2; HLA-G; TFR1A; SH3GLB2B; VPS25; PLD1A
Fc gamma R-mediated phagocytosis
FCGR3A; VASP; MAP2K1; CFL2; VAV3; PIK3CG; PIK3R5; SPHK1; FCGR1; WASF1
Regulation of actin cytoskeleton
PPP1R12B; ARHGEF12; FGF6A; ACTN4; WASLB; MYL5; ABI2; PDGFD; FGF8A; ACTN3
Choline metabolism in cancer
PDGFB; RALGDS; PIK3CG; HRAS; PPAP2C; MAPK1; PLA2G4D; MAPK9; MAP2K1; PLA2G4A

Protein Function

PIP5K1A has several biochemical functions, for example, 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIP5K1A itself. We selected most functions PIP5K1A had, and list some proteins which have the same functions with PIP5K1A. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-4-phosphate 5-kinase activity
Related Protein PIP4K2A; PIP5K1B; PIKFYVE; PIP5K1C; PIP5K1A; PIP5KL1; PIP4K2B; PIP4K2C
Function ATP binding
Related Protein KIF21A; STRC; PRKG1; CAMK2B1; DNAJA2L; FKBP4; SRR; DDX56; ADCY8; UBE2I
Function kinase binding
Related Protein RB1; JAKMIP3; DLG1; FAS; TENC1; TOLLIP; GFAP; STX1A; PPP1R9B; CAB39
Function protein binding
Related Protein MEMO1; TSHZ3; TARBP2; MEOX2; ZNF224; MYO5B; POLR1A; ASGR1; SOX17; AK3

Interacting Protein

PIP5K1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIP5K1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PIP5K1A.
CADPS; ITGB1BP2; ARL14