Active Recombinant Human PIP5K1A, GST-tagged
Cat.No. : | PIP5K1A-1460H |
Product Overview : | Recombinant full-length human PIP5K1A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | PIP5K1A or phosphatidylinositol-4-phosphate 5-kinase 1 alpha phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1 is required for Wnt3a-induced LRP6 phosphorylation at ser1490 in mammalian cells. Wnt3a stimulates the formation of phosphatidylinositol 4,5-bisphosphates through frizzled and dishevelled, the latter of which directly interacts with and activated PIP5KI. PIP5K1A-mediated PIP(2) production is crucial for HIV-1 entry and the early steps of infection in permissive lymphocytes. Overexpression of wild-type PI4P5K1A increases HIV-1 Env-mediated PIP(2) production and enhances viral replication in primary lymphocytes. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 1310nmol/min/mg |
Molecular Mass : | ~86 kDa |
Protein length : | Full length |
Purity : | >90% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [ Homo sapiens ] |
Official Symbol : | PIP5K1A |
Synonyms : | PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; PIP5KIalpha; PIP5K1-alpha; ptdIns(4)P-5-kinase 1 alpha; 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; |
Gene ID : | 8394 |
mRNA Refseq : | NM_001135636 |
Protein Refseq : | NP_001129108 |
MIM : | 603275 |
UniProt ID : | Q99755 |
Chromosome Location : | 1q21.3 |
Pathway : | 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Arf1 pathway, organism-specific biosystem; Arf6 downstream pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, conserved biosystem; |
Function : | 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-4-phosphate 5-kinase activity; ATP binding; kinase binding; nucleotide binding; protein binding; transferase activity; |
Products Types
◆ Recombinant Protein | ||
PIP5K1A-6755M | Recombinant Mouse PIP5K1A Protein, His (Fc)-Avi-tagged | +Inquiry |
PIP5K1A-170H | Active Recombinant Human PIP5K1A protein, GST-tagged | +Inquiry |
PIP5K1A-1727H | Recombinant Human PIP5K1A, GST-tagged | +Inquiry |
PIP5K1A-12828M | Recombinant Mouse PIP5K1A Protein | +Inquiry |
PIP5K1A-3893C | Recombinant Chicken PIP5K1A | +Inquiry |
◆ Lysates | ||
PIP5K1A-3173HCL | Recombinant Human PIP5K1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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