pla2g4c
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  • Official Full Name
  • phospholipase A2, group IVC (cytosolic, calcium-independent)
  • Background
  • Cytosolic phospholipase A2 (cPLA2) is a ubiquitously distributed enzyme that catalyzes the hydrolysis of the sn-2 acyl bond of glycerolipids to produce lysophospholipids and release arachidonic acid. cPLA2 has been implicated in diverse cellular responses
  • Synonyms
  • PLA2G4C; phospholipase A2, group IVC (cytosolic, calcium-independent); cytosolic phospholipase A2 gamma; cPLA2 gamma; phospholipase A2 group IVC; CPLA2-gamma; FLJ42247; FLJ44164; DKFZp586C0423
Cat.#:PLA2G4C-1753HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G4C, His-tagged
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Cat.#:PLA2G4C-3140HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLA2G4C 293 Cell Lysate
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Involved Pathway

PLA2G4C involved in several pathways and played different roles in them. We selected most pathways PLA2G4C participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G4C were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
PPAP2D; PLA2G4AA; PLA2G16; MBOAT2; PLA2G6; DGKD; ADPRM; CEPT1B; PLA2G2F; PLB1
Ether lipid metabolism
GAL3ST1; AGPS; PLA2G2D; LPCAT1; PPAP2CB; UGT8A; PLA2G2A; UGT8; CEPT1; CEPT1B
Arachidonic acid metabolism
AKR1C3; CBR2; PLA2G2E; CYP2P8; PTGES3A; FAAH2; FAM213B; PLA2G6; PLA2G12B; ALOX5
Linoleic acid metabolism
PLA2G2A; PLA2G4A; PLA2G4F; PLA2G12A; DHRS13L1; PLA2G10; CYP2C37; PLA2G5; CYP2C55; PLA2G1B
alpha-Linolenic acid metabolism
PLA2G2F; ACOX3; PLA2G4A; PLA2G12A; PLA2G3; PLA2G6; PLA2G5; ACAA1; PLA2G4AA; PLA2G2A
Metabolic pathways
PET112L; AKR1C3; GART; DNMT3; TYRP1; C1GALT1B; ATP6V0A1; COX6B2; DGAT2; POLE2
MAPK signaling pathway
TGFBR1; MAPK9; MAPK12B; MAP3K12; AKT2; MAP3K2; FGF7; HSPA1A; PPM1NB; PPP5C
Ras signaling pathway
PDGFRA; PLA2G6; VEGFB; KSR2; FOXO4; FGF2; RAC2; PLA2G1B; RASAL2; ETS2
Phospholipase D signaling pathway
LPAR4; KRAS; PLA2G4F; F2R; PPAP2C; GRM1; CYTH3; GRM6; AGPAT3; CYTH2
Vascular smooth muscle contraction
ROCK1; ARHGEF1; CALM2; CALM1; CALM3B; PPP1CB; ITPR1; CALCRLA; PPP1CC; PLA2G4AA
VEGF signaling pathway
NRAS; MAPKAPK3; MAPK14B; PLA2G4A; VEGFAA; PTGS2B; PRKCA; MAPK12B; PPP3R1; PIK3CA
Platelet activation
P2RY12; VWF; MAPK3; PLCB3; GP6; PLA2G4A; GP1BB; MYLK3; GUCY1B3; GNAI2
Fc epsilon RI signaling pathway
NRAS; PIK3CD; MAPK13; LCP2; VAV2; PIK3CA; MAP2K7; FCER1G; MAP2K6; MAPK8
Glutamatergic synapse
GNAO1; GNG2; GNG7; ITPR1; PPP3CC; GRM4; SLC17A8; GNB1; SHANK3; GRIN2D
Serotonergic synapse
ALOX8; GNGT2; Casp3; HTR1F; BRAF; HTR2C; PLCB4; ALOX12E; RAF1; GABRB2
Long-term depression
PLCB1; RAF1; LYN; IGF1R; PLA2G4D; GRIA1; CRH; GRIA3; NOS1; NRAS
Inflammatory mediator regulation of TRP channels
TRPV4; PLCB1; PRKACB; ITPR3; CYP2C39; ALOX12; PRKCQ; MAPK10; TRPM8; CALM4
GnRH signaling pathway
GNRHR2; RAF1A; LHBETA1; PRKCB; MAP2K2; MAP2K2B; MAP2K4B; CALM3B; MAP2K4A; CALM3
Ovarian steroidogenesis
CYP2J6; PRKACA; Adcy4; PRKACB; IGF1; PLA2G4F; HSD3B1; SCARB1; LHCGR; BMP15
Oxytocin signaling pathway
GNAQ; Adcy4; PPP1R12C; CALML3; PPP3R1; PIK3CG; CACNG1; CACNA2D2; CACNB4; CAMK2D
Choline metabolism in cancer
PRKCG; SLC22A5; WAS; PCYT1A; PDGFD; SLC22A3; WASL; PRKCB; DGKD; RAC3

Protein Function

PLA2G4C has several biochemical functions, for example, calcium-independent phospholipase A2 activity, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G4C itself. We selected most functions PLA2G4C had, and list some proteins which have the same functions with PLA2G4C. You can find most of the proteins on our site.
Function
Related Protein
Function calcium-independent phospholipase A2 activity
Related Protein PLA2G7; PNPLA8; PLA2G4C; PLA2G15
Function phospholipid binding
Related Protein RASAL1; APOH; ARHGAP44; BAD; ABCG1; PLA2G15; DAPP1; GOT2; PSD4; APOA1