plec
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  • Official Full Name
  • plectin
  • Background
  • Plectin interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the crosslinking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
  • Synonyms
  • PLEC1; Plectin-1; Hemidesmosomal protein 1; plectin; PLTN; PCN; plectin 1, intermediate filament binding protein 500kDa; HD1; EBS1; epidermolysis bullosa simplex 1 (Ogna); plectin 1, intermediate filament binding protein, 500kD; EBSO; PLEC1b; LGMD2Q; OTTHUMP00000229282; OTTHUMP00000229283; OTTHUMP00000229284; OTTHUMP00000229285; OTTHUMP00000229286; OTTHUMP00000229287; OTTHUMP00000229288; PLEC
Cat.#:PLEC1-32HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PLEC Protein, GST-tagged
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Cat.#:PLEC-1357HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLEC Protein, His-tagged
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Cat.#:PLEC-30873THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLEC, His-tagged
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Cat.#:PLEC-32HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PLEC Protein, GST-tagged
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Involved Pathway

PLEC involved in several pathways and played different roles in them. We selected most pathways PLEC participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Apoptosis, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alpha6-Beta4 Integrin Signaling Pathway
CLCA1; CDKN1A; RTKN; EGFR; CD151; DSP; NTN1A; CD151L; COL17A1; EIF4E
Apoptosis
DCC; IL3; PPP3CA; DIABLO; ADD1; Gzmg; BNIP3LB; DSG3; BAD; PRKAR1B
Apoptotic cleavage of cellular proteins
PLECA; CASP6L2; BCAP31; STK26; GAS2; SPNA2; BMX; STK24; CASP6L1; CTNNB2
Apoptotic execution phase
HIST1H1C; PKP1; PANK1A; H1F0; PTBP3; CASP6L1; BMX; HIST1H1A; STK26; OCLN
Assembly of collagen fibrils and other multimeric structures
COL11A1B; CTSB; COL5A1; COL4A6; LOXL2; LOX; COL6A1; CD151; COL6A3; COL8A1A
Caspase-mediated cleavage of cytoskeletal proteins
GAS2; PLEC; CASP6L2; DBNLB; VIML; ADD1; PLECA; SPNA2; CASP6L1; DBNLA
Cell junction organization
CADM2A; CLDN23; CTNND1; CDH8; CD151; CDH3; CLDN20; JUPA; DST; CDH4
Cell-Cell communication
CADM2A; SIRPA; SIRPB1; CDH11; JUPA; PLECA; CDH17; CDH9; CDH8; CDH6

Protein Function

PLEC has several biochemical functions, for example, actin binding, ankyrin binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEC itself. We selected most functions PLEC had, and list some proteins which have the same functions with PLEC. You can find most of the proteins on our site.
Function
Related Protein
Function actin binding
Related Protein PHACTR3A; TRPV4; SPIRE1A; ALDOA; SHANK3; WIPF1; GMFB; INF2; PIP; MSNA
Function ankyrin binding
Related Protein ATP1A1; SLC4A1; SCN5A; SPTBN1; NRCAM; CDH1; KCNQ2; RHAG; FLNC; PLEC
Function poly(A) RNA binding
Related Protein DHX38; RPL6; MRPL41; CCDC86; TRUB2; DDX50; ABT1; NOL12; SNRPC; NOL11
Function protein binding
Related Protein DPH3; ERO1LB; CHMP4B; RAB3B; UCP3; DCSTAMP; C10orf33; SHFM1; TGFB1I1; TWSG1
Function structural constituent of muscle
Related Protein MYL5; TPM4; ASPH; TPM1; SMTN; MYBPH; MYL9; DMD; MYL2; ACTN2

Interacting Protein

PLEC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEC here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEC.
ITGB4; FUS; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; EWSR1; SQSTM1; TSC22D1; PAN2; KCTD13; TAF15; USP20