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PLEC

  • Official Full Name

    plectin

  • Overview

    Plectin interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the crosslinking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
  • Synonyms

    PLEC1; Plectin-1; Hemidesmosomal protein 1; plectin; PLTN; PCN; plectin 1, intermediate filament binding protein 500kDa; HD1; EBS1; epidermolysis bullosa simplex 1 (Ogna); plectin 1, intermediate filament binding protein, 500kD; EBSO; PLEC1b; LGMD2Q; OTTHUMP00000229282; OTTHUMP00000229283; OTTHUMP00000229284; OTTHUMP00000229285; OTTHUMP00000229286; OTTHUMP00000229287; OTTHUMP00000229288; PLEC;

  • Recombinant Proteins
  • Human
  • E.coli
  • HEK293
  • Wheat Germ
  • GST
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLEC1-32H Recombinant Human PLEC Protein, GST-tagged Wheat Germ GST
Human PLEC-32H Recombinant Human PLEC Protein, GST-tagged Wheat Germ GST 4384 a.a. - 4493 a.a.
Human PLEC-30873TH Recombinant Human PLEC, His-tagged E.coli His
Human PLEC-1357H Recombinant Human PLEC Protein, His-tagged E.coli His
Human PLEC-1877H Recombinant Human PLEC protein, His-tagged HEK293 His Ala 4377 - Ala 4684
Human PLEC-1837H Recombinant Human PLEC protein, GST-tagged E.coli GST 1475-1768 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PLEC involved in several pathways and played different roles in them. We selected most pathways PLEC participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Apoptosis, Apoptotic cleavage of cellular proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLEC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alpha6-Beta4 Integrin Signaling PathwayYWHAQ;CD151L;CD151;COL17A1;EGFR;DSP;MST1R;NTN1A;EIF4E
ApoptosisIL3RA;IRF4;BAXB;BIRC2;IRAK2;BCL2A;DSP;NMT1;PIK3CB
Apoptotic cleavage of cellular proteinsDSP;DSG3;STK24;SATB1;DSG2;OCLN;PLECA;CLSPN;PKP1
Apoptotic execution phaseCTNNB2;STK24;DNM1L;HIST1H1A;STK24B;PLECA;PANK1A;CASP6L2;CTNNB1
Assembly of collagen fibrils and other multimeric structuresCOL4A3;TLL1;COL5A1;COL4A4;LOXL1;COL8A1;COL1A2;COL8A1A;COL6A1
Caspase-mediated cleavage of cytoskeletal proteinsDBNLB;VIML;CASP6L1;ADD1;SPNA2;CASP6L2;DBNLA;PLECA;GAS2
Cell junction organizationCDH9;CADM2;CDH12;CADM2A;FBLIM1;CLDN7;CDH8;ANG;CDH2
Cell-Cell communicationCADM2B;ITGB1B.1;CDH13;CDH8;PLEC;CDH10;CADM2;DSCAML1;PARVB

PLEC has several biochemical functions, for example, actin binding, ankyrin binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLEC itself. We selected most functions PLEC had, and list some proteins which have the same functions with PLEC. You can find most of the proteins on our site.

Function Related Protein
actin bindingPTK2;EPB41;ENC1;YWHAH;MYH11A;KCNMA1;PLECA;HIP1;GSN
ankyrin bindingRHAG;PTBP3;SLC4A1;OBSCN;SCN5A;SPTBN1;NRCAM;ATP1A1;KCNQ2
poly(A) RNA bindingENO1;XRN1;LSM2;ZFP36;HERC5;CRKL;CCT3;LUZP4;PCBP3
protein bindingRNF24;MPDZ;DENND2D;PAX8;C15orf57;PSMC3;KIF5C;KIFC3;FBXL12
structural constituent of muscleMYL6B;NEXN;MYL6;ACTN3;PLEC;TPM1;MYL1;CAPN3;MYBPH

PLEC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLEC here. Most of them are supplied by our site. Hope this information will be useful for your research of PLEC.

ITGB4; FUS; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; EWSR1; SQSTM1; TSC22D1; PAN2; KCTD13; TAF15; USP20

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