polb
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  • Official Full Name
  • polymerase (DNA directed), beta
  • Background
  • The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
  • Synonyms
  • POLB; polymerase (DNA directed), beta; DNA polymerase beta; DNA pol beta; mutant DNA polymerase beta; DNA polymerase beta subunit;
Cat.#:POLB-1014HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLB, His-tagged
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Cat.#:POLB-1521HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLB protein
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Cat.#:POLB-524HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLB protein
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Cat.#:POLB-620HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Polymerase (DNA Directed), Beta
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Cat.#:POLB-621HTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human POLB protein
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Cat.#:POLB-13067MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse POLB Protein
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Cat.#:POLB-4561RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat POLB Protein
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Cat.#:Polb-766RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Polymerase (DNA Directed), Beta
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Cat.#:POLB-3503RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey POLB Protein, His-tagged
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Cat.#:POLB-1166ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POLB
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Cat.#:POLB-1388HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human POLB cell lysate
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Involved Pathway

Polb involved in several pathways and played different roles in them. We selected most pathways Polb participated on our site, such as Base excision repair, HTLV-I infection, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Polb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base excision repair
APEX2; PARP3; HMGB1; NEIL1; LIG3; HMGB1B; xthA; PARP4; POLD4; MUTYH
HTLV-I infection
WNT2; CDC16; ETS2; CRTC3; MAP2K4; FZD3; MYB; POLE3; STAT5B; VAC14
Viral carcinogenesis
YWHAG; RBL2; HNRNPK; HIST1H4F; KRAS; CCNA2; MRPS18B; TRAF3; RBPJ; HIST1H2BA

Protein Function

Polb has several biochemical functions, for example, DNA-directed DNA polymerase activity, damaged DNA binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Polb itself. We selected most functions Polb had, and list some proteins which have the same functions with Polb. You can find most of the proteins on our site.
Function
Related Protein
Function DNA-directed DNA polymerase activity
Related Protein POLD2; PAPD7; CCDC111; POLN; POLA2; POLL; CHRAC1; POLM; POLI; POLK
Function damaged DNA binding
Related Protein XPA; TP53; POLB; APEX1; BRCA1; NEIL2; XRCC5; RPA2; RPS3; TRPC2
Function enzyme binding
Related Protein CAT; CREB1; GNB2L1; ESR1; DAOA; AXIN1; MAPT; PUS7; SIRT3; NR5A1
Function lyase activity
Related Protein NPR1A; GUCY2E; GLDC; FH1; TYW1B; HMGB1; CRY5; CAR3; Car14; POLL
Function metal ion binding
Related Protein ZMIZ2; FOXP2; CYP2AA6; NUDT14; FTR82; TRP53; ZNF843; PHYH; PDSS1; PIR
Function microtubule binding
Related Protein MTAP6; NME8; PRNP; NEFH; MAP1S; CETN2; RAE1; TPPP; NEFM; KIF11
Function protein binding
Related Protein GMPPB; EIF3L; KLRG1; MKI67IP; NUS1; NUDCD3; ZWINT; ATF1; VSNL1; TP53INP1

Interacting Protein

Polb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Polb here. Most of them are supplied by our site. Hope this information will be useful for your research of Polb.
TPP2; XRCC1; TAF1D; SRPK2; KAT7; TLE1; ssdna_dadts; Ktn1; XRCC3; Junb