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POLR1C

  • Official Full Name

    polymerase (RNA) I polypeptide C, 30kDa

  • Overview

    The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS).
  • Synonyms

    POLR1C; polymerase (RNA) I polypeptide C, 30kDa; DNA-directed RNA polymerases I and III subunit RPAC1; RPA5; RPA39; RPA40; RPAC1; AC40; RPC40; RNA polymerases I and III subunit AC1; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I a;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLR1C-28614TH Recombinant Human POLR1C, His-tagged E.coli His
Human POLR1C-1838H Recombinant Human POLR1C, GST-tagged E.coli GST 1-346aa
Human POLR1C-260H Recombinant Human POLR1C, His-tagged E.coli His 1-349aa
Human POLR1C-3041HCL Recombinant Human POLR1C 293 Cell Lysate HEK293 N/A
Human POLR1C-2762H Recombinant Human POLR1C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse POLR1C-13088M Recombinant Mouse POLR1C Protein Mammalian Cell His
Mouse Polr1c-4993M Recombinant Mouse Polr1c Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse POLR1C-6918M Recombinant Mouse POLR1C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse POLR1C-6918M-B Recombinant Mouse POLR1C Protein Pre-coupled Magnetic Beads HEK293
Zebrafish POLR1C-10846Z Recombinant Zebrafish POLR1C Mammalian Cell His
Chicken POLR1C-5010C Recombinant Chicken POLR1C Mammalian Cell His
Chicken POLR1C-5009C Recombinant Chicken POLR1C Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POLR1C Related Articles

POLR1C involved in several pathways and played different roles in them. We selected most pathways POLR1C participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLR1D;GUK1;PRPS1A;NME2B.1;POLR2A;NT5C1A;PDE1C;NME2B.2;IMPDH1
Pyrimidine metabolismPOLR2G;POLR2C;POLR1D;CMPK1;PNP;POLR3GLB;ENTPD6;AK9;PNP5A
Metabolic pathwaysPCYT1BB;NDST2;ACSS2;PPCDC;ITPKA;DEGS2;UGCG;GALNT1;POLR3K
RNA polymerasePOLR1B;POLR3GL;POLR2L;POLR2EB;POLR3K;POLR1E;ZNRD1;POLR2F;POLR2A
Cytosolic DNA-sensing pathwayPOLR3B;POLR3C;NFKBIB;OSTN;Ifna15;ADAR;CCL5;ZBP1;POLR3G
Epstein-Barr virus infectionTRAF6;NFKB1;AKT1;PIK3R5;TBK1;FCER2;GTF2E2;ENTPD1;PLCG1

POLR1C has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1C itself. We selected most functions POLR1C had, and list some proteins which have the same functions with POLR1C. You can find most of the proteins on our site.

Function Related Protein
DNA bindingHMGA1B;TBPL1;ZFP654;RAD51L3;DRAP1;SRFA;FOXN4;HMG20A;TRIM28
DNA-directed RNA polymerase activityMED21;CRCP;POLR2E;POLR3H;POLR2D;POLR2A;POLR3C;CCDC111;POLR1C
contributes_to RNA polymerase I activityPOLR2H;POLR1E;POLR2K;POLR2F;POLR1C;POLR2E;ZNRD1;POLR2L;POLR1A
contributes_to RNA polymerase III activityPOLR3H;POLR3C;POLR2H;CRCP;POLR1C;POLR3GLA;POLR3K;POLR3GLB;POLR3E
protein bindingBACE1;CYGB;CHP;EME1;CASQ2;PDPK1;RAB2A;ISYNA1;TNNI2
protein dimerization activityHPS1;MEF2D;CELSR1;STAT3;SCXA;OLIG3;NEUROG1;SOHLH1;AHRRA

POLR1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1C here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1C.

NME1; POLR1D; POLR2J; TNFAIP1

Schaefer, E; Collet, C; et al. Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome. GENETICS IN MEDICINE 16:720-724(2014).
Achilleos, A; Bugarinovic, G; et al. Polr1c and Polr1d knock-out mice as new genetic models for Treacher Collins Syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:1875-1875(2014).
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