polr1c
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  • Official Full Name
  • polymerase (RNA) I polypeptide C, 30kDa
  • Background
  • The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS).
  • Synonyms
  • POLR1C; polymerase (RNA) I polypeptide C, 30kDa; DNA-directed RNA polymerases I and III subunit RPAC1; RPA5; RPA39; RPA40; RPAC1; AC40; RPC40; RNA polymerases I and III subunit AC1; DNA-directed RNA polymerase I subunit C; DNA-directed RNA polymerases I a
Cat.#:POLR1C-1838HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR1C, GST-tagged
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Cat.#:POLR1C-260HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR1C, His-tagged
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Cat.#:POLR1C-28614THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR1C, His-tagged
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Cat.#:POLR1C-13088MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse POLR1C Protein
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Cat.#:POLR1C-5009CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken POLR1C
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Cat.#:POLR1C-5010CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken POLR1C
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Cat.#:POLR1C-10846ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POLR1C
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Cat.#:POLR1C-3041HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human POLR1C 293 Cell Lysate
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Involved Pathway

POLR1C involved in several pathways and played different roles in them. We selected most pathways POLR1C participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
NPR1A; ZNRD1; POLR3GLB; NME1; NT5C3L; PKMB; CANT1A; POLR2J; ENTPD8; POLR1C
Pyrimidine metabolism
NT5C3A; NT5C2A; NME2B.1; POLR3GLB; CTPS2; DPYDA.1; NME2A; CANT1A; NME1; CMPK
Metabolic pathways
AGXTA; POLD2; PLA2G10; AGXT; DGAT2; HPSE2; TYRP1B; POLR2D; SMS; PYCRL
RNA polymerase
POLR2D; POLR3K; POLR2F; POLR1D; POLR2B; TWISTNB; POLR2I; POLR3GLB; POLR3GL; POLR1E
Cytosolic DNA-sensing pathway
Ifna11; CCL4L2; IKBKE; POLR2L; RIPK1; LOC100033925; IFNA1; POLR3GL; PYCARD; DDX58
Epstein-Barr virus infection
EIF2AK1; PIK3CA; IL10RB; IRAK1; IRF3; CCNA2; CSNK2B; ENTPD1; POLR2I; STAT3

Protein Function

POLR1C has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1C itself. We selected most functions POLR1C had, and list some proteins which have the same functions with POLR1C. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein MYRFL; SMTNL; MYEF2; ONECUTL; XRCC6; MEIOB; SIX4B; ZNF423; HMBOX1; GLI1
Function DNA-directed RNA polymerase activity
Related Protein POLR2L; POLR2B; POLR2GL; POLR3B; MED20; POLR2E; POLR2A; POLR3A; CCDC111; POLR3G
Function contributes_to RNA polymerase I activity
Related Protein TWISTNB; POLR1E; POLR1A; ZNRD1; POLR1C; POLR2F; POLR2EB; POLR2K; POLR2H; POLR2L
Function contributes_to RNA polymerase III activity
Related Protein POLR2L; POLR1C; POLR2H; POLR3B; POLR3F; POLR1D; POLR3E; POLR2K; POLR2E; POLR3K
Function protein binding
Related Protein SUGT1; GNA13; SCP2; CASP10; MMP20; OGT; PARN; FIBCD1; OGN; KIAA0649
Function protein dimerization activity
Related Protein MESPAB; PEF1; ANO4; HER1; MITF; POLR2J2; HPSE; ATM; GPR139; SMG1

Interacting Protein

POLR1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1C here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1C.
NME1; POLR1D; POLR2J; TNFAIP1

POLR1C Related Articles

Schaefer, E; Collet, C; et al. Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome. GENETICS IN MEDICINE 16:720-724(2014).
Achilleos, A; Bugarinovic, G; et al. Polr1c and Polr1d knock-out mice as new genetic models for Treacher Collins Syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:1875-1875(2014).