polr2l
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  • Official Full Name
  • polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
  • Background
  • This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.
  • Synonyms
  • POLR2L; polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; polymerase (RNA) II (DNA directed) polypeptide L (7.6kD); DNA-directed RNA polymerases I, II, and III subunit RPABC5; hRPB7.6; hsRPB10b; RBP10; RPABC5; RPB7.6; RPB10beta; DNA directed RNA polymerase II polypeptide L; RNA polymerase II polypeptide L; RPB10; RPB10 homolog; RNA polymerase II 7.6 kDa subunit; DNA-directed RNA polymerase III subunit L; RNA polymerases I, II, and III subunit ABC5
Cat.#:POLR2L-1849HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2L, GST-tagged
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Cat.#:POLR2L-3056HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2L, His-tagged
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Cat.#:POLR2L-30688THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2L
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Cat.#:POLR2L-13102MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse POLR2L Protein
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Cat.#:POLR2L-3519RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey POLR2L Protein, His-tagged
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Cat.#:POLR2L-5644CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken POLR2L
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Cat.#:POLR2L-7432ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POLR2L
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Cat.#:POLR2L-3027HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human POLR2L 293 Cell Lysate
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Involved Pathway

POLR2L involved in several pathways and played different roles in them. We selected most pathways POLR2L participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
GMPR2; POLD2; ADPRM; POLD4; GUCY1A3; NT5C3L; PDE9A; PDE1B; IMPDH1A; GC2
Pyrimidine metabolism
POLR1A; NT5C3A; NME7; CDA; POLR2C; POLR3K; POLD2; udp; TRR1; ZNRD1
Metabolic pathways
NDUFS5; ACADS; H6PD; ALDH4A1; NFS1; POLD4; ACOT5; DHRS4L2; AK7B; BCMO1
RNA polymerase
POLR2C; POLR2A; TWISTNB; POLR1B; POLR2H; POLR2B; POLR1C; POLR1E; POLR2I; POLR2G
Cytosolic DNA-sensing pathway
CASPA; IFNA14; POLR3G; AIM2; OSTN; MB21D1; RIPK1; POLR3D; IFNPHI3; POLR2EB
Huntingtons disease
NDUFB1; ATP5G1; NDUFB3; POLR2K; POLR2G; PLCB1; NRF1; DCTN2; UQCRFS1; IFT57
Epstein-Barr virus infection
GTF2E1; GTF2E2; PSMD1; PTMA; IL10RB; MAPK12; HSPA1L; PSMD6; HSPA2; NFKBIE

Protein Function

POLR2L has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2L itself. We selected most functions POLR2L had, and list some proteins which have the same functions with POLR2L. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein TFDP1B; ILF3; HOXA10B; PALB2; SFPI1; NFIL3; ZNF566; POGZ; SOX19A; DDB2
Function DNA-directed RNA polymerase activity
Related Protein POLR3G; MED21; POLR2M; RPAP1; POLR1C; POLR3A; PRIM2; POLR2A; POLR3H; POLR2GL
Function contributes_to RNA polymerase I activity
Related Protein POLR1E; POLR1C; POLR2H; POLR2K; POLR2L; POLR1A; POLR2EB; POLR2E; POLR2F; ZNRD1
Function contributes_to RNA polymerase II activity
Related Protein POLR2K; POLR2L; POLR2J; POLR2F; POLR2E; POLR2H; POLR2J3; POLR2C; POLR2EB; POLR2A
Function contributes_to RNA polymerase III activity
Related Protein POLR3H; POLR3F; POLR2EB; POLR2L; POLR3D; POLR3G; POLR2E; CRCP; POLR3GLB; POLR3GLA
Function protein binding
Related Protein ANP32A; KAZN; PLK2; EPB41L1; USP4; EFNA3; MLPH; AGXT2L2; BCAR1; SKP1
Function zinc ion binding
Related Protein BTR22; RNF152; BIRC3; SUPT4H1; RYBPB; RNF217; NSMCE2; ESRRB; IRGF4; TRIM65

Interacting Protein

POLR2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2L here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2L.
ZBTB14; COIL; REL; TP53BP2; PHC2; BANP; L3MBTL3