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POLR2L

  • Official Full Name

    polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa

  • Overview

    This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.
  • Synonyms

    POLR2L; polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; polymerase (RNA) II (DNA directed) polypeptide L (7.6kD); DNA-directed RNA polymerases I, II, and III subunit RPABC5; hRPB7.6; hsRPB10b; RBP10; RPABC5; RPB7.6; RPB10beta; DNA directed RNA polymerase II polypeptide L; RNA polymerase II polypeptide L; RPB10; RPB10 homolog; RNA polymerase II 7.6 kDa subunit; DNA-directed RNA polymerase III subunit L; RNA polymerases I, II, and III subunit ABC5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLR2L-1849H Recombinant Human POLR2L, GST-tagged E.coli GST 1-67aa
Human POLR2L-30688TH Recombinant Human POLR2L E.coli N/A
Human POLR2L-3056H Recombinant Human POLR2L, His-tagged E.coli His
Human POLR2L-3027HCL Recombinant Human POLR2L 293 Cell Lysate HEK293 N/A
Mouse POLR2L-13102M Recombinant Mouse POLR2L Protein Mammalian Cell His
Mouse Polr2l-5002M Recombinant Mouse Polr2l Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse POLR2L-6927M-B Recombinant Mouse POLR2L Protein Pre-coupled Magnetic Beads HEK293
Mouse POLR2L-6927M Recombinant Mouse POLR2L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POLR2L-3519R Recombinant Rhesus monkey POLR2L Protein, His-tagged Mammalian Cell His
Rhesus Macaque POLR2L-3337R Recombinant Rhesus Macaque POLR2L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POLR2L-3337R-B Recombinant Rhesus Macaque POLR2L Protein Pre-coupled Magnetic Beads HEK293
Zebrafish POLR2L-7432Z Recombinant Zebrafish POLR2L Mammalian Cell His
Chicken POLR2L-5644C Recombinant Chicken POLR2L Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

POLR2L involved in several pathways and played different roles in them. We selected most pathways POLR2L participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismADAL;PGM2;POLR3E;ADCY1B;PKMB;ADA;NT5C3A;ITPA;POLR2C
Pyrimidine metabolismNME1-NME2;PNP6;NUDT2;RRM1;NT5C3A;NT5C1AA;NT5C3L;TK2;UMPS
Metabolic pathwaysSYNJ2;P4HA2;LTC4S;COX8A;CYP4A14;PGM1;HAAO;CYP11B1;ADK
RNA polymerasePOLR2E;TWISTNB;POLR2J3;POLR3A;POLR2L;POLR2K;POLR3D;POLR2J;ZNRD1
Cytosolic DNA-sensing pathwayNFKB1;POLR2F;POLR3K;IL18;MB21D1;POLR3E;IRF7;POLR1D;IFNPHI3
Huntingtons diseaseCOX7A2L;ATP5B;SLC25A5;DNAI2;COX6A1;VDAC2;UQCRC1;HAP1;BBC3
Epstein-Barr virus infectionSPI1;CSNK2A2;PIK3R2;PSMD6;TP53;POLR2J3;HLA-DQB1;POLR2E;PIK3CG

POLR2L has several biochemical functions, for example, DNA binding, DNA-directed RNA polymerase activity, contributes_to RNA polymerase I activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2L itself. We selected most functions POLR2L had, and list some proteins which have the same functions with POLR2L. You can find most of the proteins on our site.

Function Related Protein
DNA bindingSWAP70;HESX1;SSH1;ZNF643;ATF4B1;MYO18A;AKNA;MSXE;ASCL1A
DNA-directed RNA polymerase activityPOLR2GL;POLR3B;POLR3F;CCDC111;POLR2M;POLR3C;POLR2D;POLR2A;POLRMT
contributes_to RNA polymerase I activityPOLR1A;POLR1C;POLR2K;TWISTNB;POLR1E;POLR2L;ZNRD1;POLR2E;POLR2EB
contributes_to RNA polymerase II activityPOLR2H;POLR2E;POLR2EB;POLR2C;POLR2J2;POLR2J3;POLR2B;POLR2J;POLR2F
contributes_to RNA polymerase III activityPOLR3H;POLR2EB;POLR3GLB;POLR2H;POLR3E;POLR3GL;POLR2F;POLR1C;POLR3C
protein bindingRPS6;SUB1;MLL1;LDLRAP1;INHBA;ZNF16;ANAPC4;MPG;EPB42
zinc ion bindingNR2F1B;ZFP622;NR1D2;FHL2B;ZNF385B;TRIM61;WHSC1;FHL2;TRIM35-19

POLR2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2L here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2L.

ZBTB14; COIL; REL; TP53BP2; PHC2; BANP; L3MBTL3

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