ppm1l
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  • Official Full Name
  • protein phosphatase, Mg2+/Mn2+ dependent, 1L
  • Background
  • PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other;phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs;regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular;stimuli (Jin et al., 2004 (PubMed 15560375)).
  • Synonyms
  • PPM1L; protein phosphatase, Mg2+/Mn2+ dependent, 1L; protein phosphatase 1 (formerly 2C) like; protein phosphatase 1L; PP2CE; PP2Cepsilon; Protein phosphatase 2C epsilon isoform; PP2C epsilon; protein phosphatase 2C isoform epsilon; PPM1-LIKE; PP2C-epsilo
Cat.#:PPM1L-80HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human PPM1L protein, His-tagged
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Cat.#:PPM1L-13204MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPM1L Protein
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Cat.#:PPM1L-2956HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPM1L 293 Cell Lysate
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Involved Pathway

PPM1L involved in several pathways and played different roles in them. We selected most pathways PPM1L participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1L were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism
ACOT11; BSG; LMF1; CYP4F22; DUT; SLC26A2; SLC25A16; NQO1; MED25; STAB2
Metabolism of lipids and lipoproteins
APOA5; ANKRD1; MED21; CPNE7; LBR; APOEA; CTGF; ARV1; APOA4A; DPEP1
Sphingolipid de novo biosynthesis
SPTLC1; GDF1; PPM1LB; SGMS2; VAPB; CERS5; OSBP; CERS3B; FA2H; CERS4A
Sphingolipid metabolism
ENPP7; PPAP2B; NEU3.5; GAL3ST1; ARSA; SUMF2; CERS2; ASAH2; SPTLC2A; SGMS1

Protein Function

PPM1L has several biochemical functions, for example, metal ion binding, protein serine/threonine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1L itself. We selected most functions PPM1L had, and list some proteins which have the same functions with PPM1L. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein ARAF; PRSS37; CYB561A3A; IRF2BP2A; ZBTB42; ZFP710; CLEC7A; ZNF705A; ZNF398; EGLN1B
Function protein serine/threonine phosphatase activity
Related Protein PPM1NB; PPP1R3D; MTMR3; UBLCP1; DUSP23; PPP1CC; PPM1LA; PPM1H; PPP5C; PPM1BA