Ppp2r2a
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Official Full Name
protein phosphatase 2, regulatory subunit B, alpha
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Cynomolgus
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Avi
- Fc
Involved Pathway
Ppp2r2a involved in several pathways and played different roles in them. We selected most pathways Ppp2r2a participated on our site, such as mRNA surveillance pathway,Sphingolipid signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ppp2r2a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis C | CLDN4,OAS2,NFKBIA,CLDN8,PIK3CG,MAPK12,OAS1,RAF1,BRAF,OAS1B |
| Hippo signaling pathway | LATS1,AFP,YWHAZ,GSK3B,PRKCI,TEAD1,WNT11,SERPINE1,TCF7,PPP1CC |
| mRNA surveillance pathway | PPP1CAB,EIF4A3,PPP2CA,PABPC1A,DDX39B,PPP2R2CA,BCL2L2-PABPN1,HBS1L,RBM8A,PABPC1L |
| Dopaminergic synapse | PPP1CA,DDC,CREB3L1,MAPK13,GNG4,GRIA4,CALM1,CREB3L2,GSK3B,GNAI1 |
| Tight junction | MYH6,CDC42L2,VMHC,MYH13,MYHC4,PRKCBB,MYLPF,SHROOM3,PRKCZ,MYHZ2 |
| Sphingolipid signaling pathway | TRP53,NRAS,RAC3,PIK3CA,RAC2,PPP2R1A,DEGS1,PDPK1,PPP2R1B,BCL2 |
| PIK-Akt signaling pathway | TNXB,IFNA8,FLT4,SGK3,MLST8,FGFR2,IL7,BCL2,PGF,HSP90B1 |
| AMPK signaling pathway | CCNA2,CREB3L1,PIK3R2,AKT1S1,RPTOR,PRKAA1,IGF1,CD36,PPP2CA,PPP2R5B |
| Chagas disease (American trypanosomiasis) | PPP2R2B,PIK3R3,MYD88,MAPK3,TGFB3,CCL3L1,TGFB2,PIK3CG,NOS2,MAPK13 |
Protein Function
Ppp2r2a has several biochemical functions, for example, protein binding,protein complex binding,protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ppp2r2a itself. We selected most functions Ppp2r2a had, and list some proteins which have the same functions with Ppp2r2a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase type 2A regulator activity | PPP2R5C,PPP2R5EA,PPP2R5CB,PPP2R5EB,PPP2R5B,PPME1,PPP2R2B,PPP2R3A,PPP2R2D,PPP2R5D |
| protein serine/threonine phosphatase activity | PDP2,ILKAP,EPM2A,PPEF2,CDC14C,PPM1DB,PPP4C,PPP2R1A,CTDNEP1A,PPM1BB |
| protein binding | DPH2,LSM11,POP1,PEX19,MAX,RAB9A,PHLDA1,PHF16,BLCAP,CEP170L |
| protein phosphatase 2A binding | EIF4EBP1,SMG7,PTPN1,SMG5,HMGCR,RPS6KB1,STRN,AKT1,PPME1,ENSAA |
| protein complex binding | GNB2,C8G,CDK2,ABI2,RAP1A,NCOA1,ANKRD32,TXN2,NFKBIA,PPFIA2 |
| tau protein binding | APOE,SNCA,SERPINB1A,HDAC6,S100B,BIN1,FKBP4,AATF,DYRK1A |
Interacting Protein
Ppp2r2a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ppp2r2a here. Most of them are supplied by our site. Hope this information will be useful for your research of Ppp2r2a.
PPP2R1A;PPP2CA;PPP2CB;PPP2R1B
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References
- Kurimchak, A; Grana, X; et al. PP2A: more than a reset switch to activate pRB proteins during the cell cycle and in response to signaling cues. CELL CYCLE 14:18-30(2015).
- Zhang, DB; Wang, J; et al. miR-136 Modulates TGF-beta 1-Induced Proliferation Arrest by Targeting PPP2R2A in Keratinocytes. Biomed Research International :-(2015).
