Recombinant Cynomolgus PPP2R2A Protein, His-tagged
Cat.No. : | PPP2R2A-807C |
Product Overview : | Recombinant Cynomolgus PPP2R2A full length or partial length protein was expressed. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian Cells |
Species : | Cynomolgus |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC. |
Storage Buffer : | PBS buffer |
Gene Name : | PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [ Macaca fascicularis (crab-eating macaque) ] |
Official Symbol : | PPP2R2A |
Synonyms : | PPP2R2A; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha; |
Gene ID : | 101926197 |
mRNA Refseq : | NM_001283453 |
Protein Refseq : | NP_001270382 |
MIM : | |
UniProt ID : | Q4R7Z4 |
Products Types
◆ Recombinant Protein | ||
PPP2R2A-4293R | Recombinant Rat PPP2R2A Protein, His (Fc)-Avi-tagged | +Inquiry |
PPP2R2A-550C | Recombinant Cynomolgus Monkey PPP2R2A Protein, His (Fc)-Avi-tagged | +Inquiry |
PPP2R2A-7032M | Recombinant Mouse PPP2R2A Protein, His (Fc)-Avi-tagged | +Inquiry |
PPP2R2A-2577C | Recombinant Chicken PPP2R2A | +Inquiry |
PPP2R2A-4634R | Recombinant Rat PPP2R2A Protein | +Inquiry |
◆ Lysates | ||
PPP2R2A-2924HCL | Recombinant Human PPP2R2A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionFollowing the downregulation of PPP2R2A using shRNA, a significant increase in GFPT2 phosphorylation levels was observed, while the phosphorylation levels of GFPT1 did not show significant changes.
The study used tandem affinity purification combined with HPLC-Chip-ESI/MS/MS to screen for proteins interacting with PPP2R2A.
The analysis revealed that Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) and Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) are potential binding partners of PPP2R2A.
The interaction between PPP2R2A and GFPT1/GFPT2 was further confirmed through methods such as immunofluorescence co-localization, GST Pull-down, and immunoprecipitation.
PPP2R2A is one of the regulatory subunits of the PP2A phosphatase. Past research reports indicate that PPP2R2A can promote tumor cell survival and growth.
The study used immunofluorescence co-localization, GST Pull-down, and immunoprecipitation methods to further confirm the direct interaction between PPP2R2A and GFPT2.
GFPT2 is a rate-limiting enzyme in the O-GlcNAc glycosylation modification pathway. In breast cancer cells (MDA-MB-231), downregulation of PPP2R2A led to an increase in protein O-GlcNAc glycosylation levels.
Customer Reviews (3)
Write a reviewWe observed remarkable consistency in product performance across multiple batches, reducing variability in our experiments.
The reliability of the product's quality and effectiveness from one batch to another instilled confidence in its usage.
The product's batch-to-batch consistency was a key factor in the success of our long-term research projects.
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